lta
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  • Official Full Name
  • lymphotoxin alpha (TNF superfamily, member 1)
  • Background
  • The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin''''s lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.
  • Synonyms
  • LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNF-beta; LT-alpha
Cat.#:LTA-1223HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LTA Protein, MYC/DDK-tagged
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Cat.#:LTA-4597HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LTA Protein, GST-tagged
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Cat.#:LTA-4599HTag:His|Flag|StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human LTA Protein, His/Flag/StrepII-tagged
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Cat.#:LTA-221HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human LTA, StrepII-tagged
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Cat.#:LTA-260HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Lymphotoxin Alpha
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Cat.#:LTA-31074THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LTA, His-tagged
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Cat.#:LTA-310HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human LTA protein
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Cat.#:LTA-311HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Lymphotoxin Alpha, His-tagged
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Cat.#:LTA-31534THTag:His
Source (Host):Species:Human
Product nameRecombinant Human LTA, His-tagged
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Cat.#:LTA-31535THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LTA
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Cat.#:LTA-31536THTag:His
Source (Host):Species:Human
Product nameRecombinant Human LTA, His-tagged
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Cat.#:LTA-554HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LTA, None tagged
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Cat.#:LTA-568HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LTA protein, His & T7-tagged
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Cat.#:Lta-569MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lta protein, His-tagged
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Cat.#:LTA-9342MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LTA Protein
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Cat.#:LTA-3497RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LTA Protein
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Cat.#:Lta-571RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lta protein, His-tagged
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Cat.#:LTA-2589RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey LTA Protein, His-tagged
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Cat.#:LTA-567DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog LTA protein, His-tagged
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Cat.#:LTA-572RTag:His|T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit LTA protein, His & T7-tagged
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Cat.#:LTA-3065ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LTA
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Cat.#:LTA-570PTag:His|T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig LTA protein, His & T7-tagged
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Cat.#:LTA-5067HTag:N/A
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human Lymphotoxin Alpha (TNF superfamily, member 1)
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Cat.#:LTA-5068HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Lymphotoxin Alpha (TNF superfamily, member 2), His-tagged
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Cat.#:LTA-165HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Lymphotoxin Alpha (TNF Superfamily, Member 1)
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Cat.#:LTA-1253HTag:HQ
Source (Host):Hordeum vulgare (barley grain)Species:Human
Product nameRecombinant Human Lymphotoxin Alpha (TNF superfamily, member 1), HQ-tagged
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Cat.#:LTA-9167HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human LTA 293 Cell Lysate
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Cat.#:TNFB-89HTag:N/A
Source (Host):Species:Human
Product nameHuman Tumour Necrosis Factor beta (rDNA derived) Reference standard
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Cat.#:Lta-90MTag:N/A
Source (Host):Species:Mouse
Product nameMouse Tumour Necrosis Factor alpha (rDNA derived) Reference standard
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Involved Pathway

LTA involved in several pathways and played different roles in them. We selected most pathways LTA participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
PF4; KDR; NGFR; CCL27; Cxcl15; IL6; IFNA1; IL2RGB; IFNPHI1; TNFRSF9A
NF-kappa B signaling pathway
TRAF1; BIRC3; PRKCB; BTK; CD40; PLCG2; MAP3K7; DDX58; LRDD; Ccl21a
TNF signaling pathway
TNFAIP3; LIF; AKT1; CXCL1; SELE; TRAF3; TNF; DNM1L; RIPK1; CXCL2
Type I diabetes mellitus
ICA1; HLA-DMB; IL12B; HLA-F; Fasl; Il2; IL12A; HLA-DOB; HLA-E; FAS
HTLV-I infection
ICAM1; HLA-DPB1; FZD3; RELB; EGR2; HLA-B; FZD9; ITGB2L; LTBR; ATF3
Herpes simplex infection
HCFC1; JAK2B; SRSF7A; TRAF1; MYD88; EIF2S1B; HLA-DMA; CD74; TNFRSF1A; LOC100033925

Protein Function

LTA has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LTA itself. We selected most functions LTA had, and list some proteins which have the same functions with LTA. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IL23; CSF3; GREM1; CMTM3; GDF7; TNFSF18; CMTM2; HMGB1B; TNFSF8; IFNPHI2
Function receptor binding
Related Protein IZUMO1; ANXA1; CRAT; LIF; CRH; HAMP; CAPRIN2; HLA-F; ARPP19; TGFB2
Function tumor necrosis factor receptor binding
Related Protein TNFSF12; EDA; TNFSF10L4; TRADD; FADD; ERAP1; TNFSF10; CD70; TNFSF10L3; CASP8

Interacting Protein

LTA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTA here. Most of them are supplied by our site. Hope this information will be useful for your research of LTA.
LGALS2; TUBA1A; TNFRSF14; BIRC2; RIPK1

LTA Related Articles

Leroux-Kozal, V; Leveque, N; et al. Merkel cell carcinoma: histopathologic and prognostic features according to the immunohistochemical expression of Merkel cell polyomavirus large T antigen correlated with viral load. HUMAN PATHOLOGY 46:443-453(2015).
Dammermann, W; Bochmann, D; et al. CMV specific cytokine release assay in whole blood is optimized by combining synthetic CMV peptides and toll like receptor agonists. JOURNAL OF IMMUNOLOGICAL METHODS 414:82-90(2014).