| Species : |
Human |
| Source : |
HEK293 |
| Tag : |
Non |
| Protein Length : |
35-205aa |
| Description : |
Lymphotoxin-alpha (LT-alpha), also known as Tumor Necrosis Factor-beta (TNF-beta), is a member of the TNF Superfamily. Human LT-alpha/TNF-beta is a 22 kDa protein that shares 73% amino acid sequence identity with mouse and rat LT-alpha/TNF-beta. Secreted LT-alpha forms homotrimers that bind and activate TNF RI/TNFRSF1A, TNF RII/TNFRSF1B, and HVEM/TNFRSF14. LT-alpha/TNF-beta also forms heterotrimers with plasma membrane-localized LT-beta to bind and activate the LT-beta R/TNFRSF3. In addition to its cytotoxic action on tumor cells, LT-alpha/TNF-beta mediates lymph node development, inflammation, and immune function. LT-alpha/TNF-beta is expressed in activated T- and B lymphocytes and contributes to autoimmune disease. |
| Tag : |
Non |
| Molecular Mass : |
19 kDa |
| Endotoxin : |
Less than 1.0 EU/μg by the LAL method. |
| Purity : |
>95% as determined by SDS-PAGE. |
| Storage : |
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Storage Buffer : |
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol. |
| Reconstitution : |
Reconstitute at 250 μg/mL in sterile water. |
