LTA
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Official Full Name
lymphotoxin alpha (TNF superfamily, member 1)
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Overview
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin''''s lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. -
Synonyms
LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNF-beta; LT-alpha;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Bacillus subtilis
- Dog
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Rhesus Macaque
- S. aureus
- Zebrafish
- E.coli
- HEK293
- HEK293 cells
- HEK293T
- Hordeum Vulgare
- Human
- Human Cell
- Human cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian cell
- Mammalian Cell
- Mammalian cells
- Mouse
- Wheat Germ
- Biotin
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- His|Flag|StrepII
- His|T7
- HQ
- MYC
- DDK
- Myc|DDK
- N/A
- N
- Strep II
- Involved Pathway
- Protein Function
- Interacting Protein
- LTA Related Articles
- LTA Related Signal Pathway
LTA involved in several pathways and played different roles in them. We selected most pathways LTA participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | IL10;CCL20A.3;AMH;KITLGA;CCL25B;KDR;CXCL8;IL22RA1;IL4R |
NF-kappa B signaling pathway | TRAF1;LY96;CXCL12;TNFSF13B;BCL2;PLAU;LBP;PLCG1;GADD45B |
TNF signaling pathway | PIK3CB;TRADD;MMP9;PIK3R2;CCL2;BIRC3;MAP3K7;CASP8;CXCL3 |
Type I diabetes mellitus | HLA-A;HLA-DMA;GZMB;PRF1;FAS;TNF;HLA-E;HLA-DRB5;HLA-DQA2 |
HTLV-I infection | NFATC1;SMAD3;SFPI1;CCND1;TGFB1;LTBR;FZD8;ITGAL;HLA-DRB5 |
Herpes simplex infection | EP300;HLA-DRB5;TLR9;SRSF1B;PPP1CAA;HLA-G;CDK1;C3;IL12BA |
LTA has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LTA itself. We selected most functions LTA had, and list some proteins which have the same functions with LTA. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | TNFSF14;GDF10;Gm13290;TIMP1;IFNW1;GM13288;Il1f9;GREM1A;IFNPHI4 |
receptor binding | FASLG;NTF3;DPP4;GBA;FGF20A;EDA;CD2;GSDMA2;FGF12B |
tumor necrosis factor receptor binding | CASP8;TNFSF13;ERAP1;FADD;TRAF6;TRAF4;TNFSF14;TNFSF12;TRAF1 |
LTA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTA here. Most of them are supplied by our site. Hope this information will be useful for your research of LTA.
LGALS2; TUBA1A; TNFRSF14; BIRC2; RIPK1
- Q&As
- Reviews
Q&As (5)
Ask a questionLTA protein is being investigated for its potential use in cancer therapy, autoimmune diseases, and infectious diseases.
Clinical trials may have been initiated to investigate the therapeutic potential of LTA protein since my last update. It's advisable to check the latest information.
Potential side effects may include immune-related adverse events, such as inflammation and cytokine release syndrome.
LTA protein has been studied for its potential to modulate autoimmune responses, but more research is needed.
LTA protein has shown potential in cancer immunotherapy by targeting and destroying cancer cells.
Customer Reviews (3)
Write a reviewIts purity, integrity, and functionality are ensured through stringent quality control measures, which instills confidence in the reliability and accuracy of my research results.
Their technical expertise, product quality, customer support, and supply management collectively contribute to the success and progress of my trials.
The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.
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