mdm2
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  • Official Full Name
  • MDM2 oncogene, E3 ubiquitin protein ligase
  • Background
  • This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
  • Synonyms
  • MDM2; MDM2 oncogene, E3 ubiquitin protein ligase; HDMX; hdm2; ACTFS; E3 ubiquitin-protein ligase Mdm2; oncoprotein Mdm2; Mdm2, p53 E3 ubiquitin protein ligase homolog; double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein;
Cat.#:MDM2-651MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse MDM2 Protein (1-489 aa), His-tagged
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Cat.#:MDM2-568HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2 Protein, His-tagged
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Cat.#:MDM2-105HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2, His-tagged
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Cat.#:MDM2-1063HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mdm2 p53 Binding Protein Homolog, GST-tagged
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Cat.#:MDM2-1064HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mdm2 p53 Binding Protein Homolog, His-tagged
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Cat.#:MDM2-1065HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MDM2, GST-tagged
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Cat.#:MDM2-110HTag:His6-HA-SUMO
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human MDM2, His6-HA-SUMO-tagged
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Cat.#:MDM2-134HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2 protein, T7/His-tagged
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Cat.#:MDM2-1518HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human MDM2 protein
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Cat.#:MDM2-2319HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2
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Cat.#:MDM2-2320HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2, GST-tagged
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Cat.#:MDM2-29009THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MDM2
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Cat.#:MDM2-29756THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2, His-tagged
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Cat.#:MDM2-306HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MDM2
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Cat.#:MDM2-350HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human MDM2, His-tagged
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Cat.#:MDM2-4858HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mdm2 P53 Binding Protein Homolog (Mouse), GST-tagged
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Cat.#:MDM2-6982HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDM2, GST-tagged
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Cat.#:MDM2-9667MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Mdm2 Protein, His-tagged
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Cat.#:MDM2-2711RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MDM2 Protein, His-tagged
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Cat.#:MDM2-4264CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MDM2
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Cat.#:MDM2-8944ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MDM2
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Cat.#:MDM2-4404HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MDM2 293 Cell Lysate
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Involved Pathway

MDM2 involved in several pathways and played different roles in them. We selected most pathways MDM2 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
PRKAB1; IGF1; SGK1; STK4; IGF1RB; MAPK12B; BCL6A; PIK3R3A; CCND2A; GRB2B
Cell cycle
CDK6; CENPW; CCNH; LIN52; CDC25C; TGFB1; CEP78; SGOL2; PKMYT1; NEK2
p signaling pathway
GADD45AA; PIDD1; GADD45AB; FAS; SESN1; TRP53; BIDA; CCNG1; CCND2A; CCNE2
Ubiquitin mediated proteolysis
RCHY1; CBLC; UBE2KB; UBE2I; TRAF6; UBA2; CDC26; FBXW7; UBE2L3; PIAS2
Endocytosis
AMPH; CLTCA; CHMP3; CDC42L; PIP5KL1; KDRL; CAV3; GRK1; EHD4; CXCR4A
PIK-Akt signaling pathway
GNG3; NGF; PIK3R3; PPP2R2A; IL4; CREB3L2; ITGB1; PKN3; SGK1; BAD
Thyroid hormone signaling pathway
MED24; PLCZ1; PLCB3; ATP1B2; ITGAV; ITGB3; TRP53; RXRG; PIK3CB; RHEB
Epstein-Barr virus infection
PLCG1; PSMC5; HSPB2; HLA-DPA1; PSMC2; MAPK9; POLR3GL; POLR2L; NFKB1; TAB2
Pathways in cancer
BDKRB1; VEGFC; TGFB2; CYCS; PLD1; MAPK8; HIF1A; WNT8B; LPAR5; GNG7
Transcriptional misregulation in cancer
MMP9; HIST2H3A; CDK14; MYCN; IL1R2; TRAF1; SP1; CD86; Bcl2a1b; SIX1
Viral carcinogenesis
BAX; GTF2H2C_2; HIST2H4; CCNA1; VAC14; RBPJL; HIST1H2BI; BAD; EGR3; SNW1
Proteoglycans in cancer
MMP9; PLAUR; PRKCA; WNT4; CAMK2G; PIK3R1; WNT1; Fzd4; VAV2; PIK3CD
MicroRNAs in cancer
SHC1; IGF2BP1; PDGFB; EP300; THBS1; ABCC1; SLC7A1; DDIT4; SERPINB5; SOCS1
Glioma
PIK3R1; MTOR; KRAS; CALM3; PDGFB; CALML3; PIK3CD; TRP53; IGF1; PLCG2
Prostate cancer
PIK3R2; CREB3L2; NRAS; HRAS; PDGFC; PIK3CD; PIK3R1; TRP53; CASP9; PDGFA
Melanoma
FGF8; MDM2; PIK3R2; FGF14; FGF12; PDGFC; PDGFA; RAF1; AKT1; PIK3CD
Bladder cancer
UPK3A; NRAS; E2F2; TYMP; ARAF; MAPK1; BRAF; MMP2; FGFR3; VEGFA
Chronic myeloid leukemia
CRKL; IKBKB; SHC2; PIK3R1; CBL; SHC3; PIK3CA; TGFBR2; PIK3CD; CCND1

Protein Function

MDM2 has several biochemical functions, for example, enzyme binding, identical protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MDM2 itself. We selected most functions MDM2 had, and list some proteins which have the same functions with MDM2. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein CDK19; MST1R; IQCB1; DAOA; EGFR; MARCH6; Slc4a2; ECM1; TSPAN33; SPDL1
Function identical protein binding
Related Protein RYR2; PRMT8; LRRK2; CHAF1A; FZD1; ALDOA; MRFAP1L1; MAPK1IP1; CHMP4B; PARK2
Function ligase activity
Related Protein RNF139; TRIM69; DZIP3; TRAIP; DTX4; RNF20; TRIM6; TRIM24; TNFAIP3; RNF144AB
Function p53 binding
Related Protein ZFP346; USP10; NUAK1; RNF34; MAPKAPK5; DUSP26; TP73; HSPD1; TP53; ZMAT3
Function protein binding
Related Protein GAL; CCDC101; OSBPL1A; KIAA0368; IFNAR1; CD8B1; TYR; LRFN2; POU3F3; SSX1
Function scaffold protein binding
Related Protein P2RY1; GRIN2A; LRP4; CASP8; NCK2; SRC; KRT8; CHRNA7; NOS1; SHANK1
Function ubiquitin protein ligase activity
Related Protein CDC34; UBE3B; TRIM3; UBE2Z; SIAH2L; UBE3C; PPIL2; UBE2H; SIAH2; UBE2G2
Function ubiquitin protein ligase binding
Related Protein NGFR; TNFRSF1B; UQCRC1; STX8; TNFRSF14; TXNIP; STUB1; ARRB2; CUL1B; UBXN1
Function ubiquitin-protein transferase activity
Related Protein RNF125; DTX3L; RNF182; SMURF1; FBXO2; MARCH4; RNF6; UBE3C; TRAF4B; MYLIP
Function zinc ion binding
Related Protein PJA2; PCGF5A; ZDHHC22; AGBL4; MARCH6; ZNF385D; OTUD7B; NR1D1; NANOS3; NR1D2

Interacting Protein

MDM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDM2.
TP53

MDM2 Related Articles

Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).
Herting, F; Herter, S; et al. Combination of the Glycoengineered Type II CD20 Antibody Obinutuzumab (GA101) and the MDM2 Selective Antagonist RG7388 Results in Superior Anti-Tumor Activity. BLOOD 124:-(2014).