MDM2
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Official Full Name
MDM2 oncogene, E3 ubiquitin protein ligase
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Overview
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] -
Synonyms
MDM2; MDM2 oncogene, E3 ubiquitin protein ligase; HDMX; hdm2; ACTFS; E3 ubiquitin-protein ligase Mdm2; oncoprotein Mdm2; Mdm2, p53 E3 ubiquitin protein ligase homolog; double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- Human
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|HA|SUMO
- N/A
- N
- No tag
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- MDM2 Related Articles
- MDM2 Related Research Area
- MDM2 Related Signal Pathway
MDM2 involved in several pathways and played different roles in them. We selected most pathways MDM2 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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FoxO signaling pathway | STK11;HOMER1B;INSRB;SMAD3;PLK1;MAPK8;GADD45AB;ATG12;SMAD2 |
Cell cycle | NEK9;SMC1B;SPC25;SETA;CCND3;MAU2;RAD9B;ENSAA;SYNE1 |
p signaling pathway | SIAH1A;PPM1DB;CYCSB;LRDD;RRM2;CCND1;RPRMA;SIAH2L;MDM2 |
Ubiquitin mediated proteolysis | FBXW8;SKP2;CUL4A;UBA1;TRAF6;PIAS4B;MGRN1B;ITCH;ANAPC11 |
Endocytosis | NEDD4L;DNM1B;VPS4A;CBLC;ADRB3;CAV3;ARFGEF2;HRASB;ZFP652 |
PIK-Akt signaling pathway | IFNA6;IFNA1;YWHAH;LAMA2;PIK3R5;ITGB8;MTOR;VEGFB;GNG11 |
Thyroid hormone signaling pathway | ITGAV;PIK3R2;PRKACB;NOTCH2;DIO3;PLCD4;THRA;SLC16A10;THRB |
Epstein-Barr virus infection | POLR1D;CD38;MAP2K7;POLR2H;HLA-DRB5;TAB1;HLA-DPB1;PSMD12;IKBKB |
Pathways in cancer | TRAF2;STAT5A;PRKCA;LAMA1;PIK3CG;MDM2;LAMB2;PLCG2;ROCK1 |
Transcriptional misregulation in cancer | PBX1;TP53;H3F3C;HOXA11;MLL1;DOT1L;ATF1;ZBTB17;MAX |
Viral carcinogenesis | HIST1H4I;HLA-G;DNAJA3;PMAIP1;LTBR;NFKBIA;ACTN2;HDAC10;HIST1H2BD |
Proteoglycans in cancer | ESR1;SOS1;COL21A1;ROCK2;WNT16;ITPR3;PIK3R2;PPP1R12C;PLAU |
MicroRNAs in cancer | IRS1;CDCA5;ZEB1;SOCS1;TPM1;NOTCH3;MARCKS;SOS1;MAP2K1 |
Glioma | RB1;CALM1;MDM2;CAMK2G;TRP53;CALM3;CAMK2D;CAMK2B;PIK3R2 |
Prostate cancer | RELA;EP300;PDGFRB;MAPK3;SRD5A2;PIK3R1;SOS1;TCF7;SPRY1 |
Melanoma | FGF21;MAP2K2;FGF13;FGF4;MITF;FGF16;PIK3R5;TP53;PTEN |
Bladder cancer | RASSF1;TYMP;BRAF;CDK4;MMP1A;MMP9;MAP2K1;FGFR3;E2F2 |
Chronic myeloid leukemia | AKT1;NRAS;CRK;RB1;MECOM;TGFBR2;ABL1;PIK3R1;SMAD3 |
MDM2 has several biochemical functions, for example, enzyme binding, identical protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MDM2 itself. We selected most functions MDM2 had, and list some proteins which have the same functions with MDM2. You can find most of the proteins on our site.
Function | Related Protein |
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enzyme binding | SELS;MAPK8;USP22;DDX5;HINFP;NOXA1;HYAL2;TSPAN10;UBE2L3 |
identical protein binding | AXIN1;VWA1;ATG16L1;CIDEB;MTPAP;NLRC4;FXR2;CBX3;PRNP |
ligase activity | TRIM8;PIAS1;PJA2;ATG3;RC3H2;MARCH9;RNF38;MKRN2;AMFR |
p53 binding | ANKRD1;EHMT1;TRIAP1;RNF34;TP63;CDK5;ZMAT3;CDKN2A;PLK3 |
protein binding | AK8;HECTD3;C3orf52;BAHD1;S100A10;KDRL;SHISA3;ARMCX1;IL6 |
scaffold protein binding | TREM2;PANX1;KCNQ1;DLG4;DSP;SHANK1;KRT5;KCNA5;CASP8 |
ubiquitin protein ligase activity | RNF122;UBE2J2;UBE2G1B;PDZRN3B;UBE3B;MED21;LTN1;TRIM71;RNF139 |
ubiquitin protein ligase binding | AXIN2;RANGAP1;CUL3A;DNAJA1;TRAF2;CUL3B;CD40;RALB;UBE2L3 |
ubiquitin-protein transferase activity | FBXO7;FBXL14;SIAH1A;TRIM24;RNF125;RNF25;PAX6;ZYG11B;CNOT4B |
zinc ion binding | MAN2A1;LHX2A;MLL1;MAN2B1;VDRA;MAN2A2;BMP1B;MKRN3;TRIM42 |
MDM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDM2.
TP53
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Q&As (7)
Ask a questionMDM2 binds directly to p53, inhibiting its transcriptional activity. Additionally, MDM2 ubiquitinates p53, targeting it for proteasomal degradation, thus regulating p53 levels in the cell.
The MDM2-p53 feedback loop is crucial for cellular homeostasis. When DNA damage occurs, p53 levels rise, leading to cell cycle arrest or apoptosis. Elevated p53 can induce MDM2 expression, which in turn downregulates p53, ensuring that p53 activity is transient.
Amplifications or overexpression of MDM2 can lead to reduced p53 activity, even in the presence of DNA damage or other stress signals, potentially contributing to uncontrolled cell proliferation and tumorigenesis.
Several small molecule inhibitors, like Nutlin-3 and RG7112, target MDM2 to prevent its interaction with p53, thereby stabilizing and activating p53. These inhibitors hold therapeutic potential, especially in tumors with wild-type p53 but overexpressed MDM2.
Besides p53, MDM2 interacts with other proteins, including E2F1 and RB, influencing cell cycle progression and apoptosis. The balance of these interactions can determine cell fate.
The MDM2 gene encodes a nuclear-localized E3 ubiquitin ligase. Its primary function is to regulate the p53 tumor suppressor protein's stability and activity.
Therapeutic strategies targeting MDM2 include the use of MDM2 inhibitors to reactivate p53, combination therapies with DNA-damaging agents, and strategies to disrupt MDM2's interaction with other proteins to modulate cell cycle and apoptosis.
Customer Reviews (3)
Write a reviewValidated in multiple assays.
Great for cell culture.
Consistent performance, highly reproducible.
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