MMP1
-
Official Full Name
matrix metallopeptidase 1 (interstitial collagenase)
-
Overview
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] -
Synonyms
MMP1; matrix metallopeptidase 1 (interstitial collagenase); CLG; CLGN; interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Others
- Protein Pre-coupled Magnetic Beads
- Cattle
- Human
- Pig
- Rabbit
- Rat
- CHO
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human Fibroblasts
- In Vitro Cell Free System
- Insect Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His(C
- ter)
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- MMP1 Related Articles
- MMP1 Related Gene Family
- MMP1 Related Research Area
MMP1 involved in several pathways and played different roles in them. We selected most pathways MMP1 participated on our site, such as PPAR signaling pathway, Pathways in cancer, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
PPAR signaling pathway | FABP3;ADIPOQB;SLC27A5;ACSL1A;ACOX3;FABP1;ANGPTL4;ACAA1;FADS2 |
Pathways in cancer | IGF1;PLCB2;PAX8;CASP8;ARHGEF1;TRAF5;ITGA3;ITGA6;GLI2 |
Bladder cancer | E2F1;CDH1;MDM2;MAPK3;NRAS;HBEGF;CDK4;HRAS;EGF |
Rheumatoid arthritis | CD86;H2-AA;TGFB3;HLA-DOA;FOS;Ccl12;ICAM1;HLA-DRB1;IL15 |
MMP1 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP1 itself. We selected most functions MMP1 had, and list some proteins which have the same functions with MMP1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
calcium ion binding | DGKAA;PCDHGC3;PADI3;CABP5A;RHOT2;PLCD3A;PVALB5;PCDH2G9;SYT17 |
endopeptidase activity | ECE1;PSMB7;CD46;RHBDD1;ELANE;KLK1B26;REN2;KLK1B3;KLK1B8 |
metalloendopeptidase activity | PHEX;MMP24;PMPCB;ADAM21;ADAMTS16;MMP15;UQCRC1;ADAM15;MMP30 |
zinc ion binding | EWSR1B;ZDHHC18;CPA6;TP53;TRIM35-34;BRD1;LIMCH1A;QPCTL;IRGF4 |
MMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP1.
F2R; SOX8
- Q&As
- Reviews
Q&As (5)
Ask a questionMMP1 is involved in the remodeling of tissue during wound healing by facilitating the breakdown of damaged extracellular matrix components.
Inhibiting MMP1 activity is being explored as a potential therapeutic strategy to impede cancer progression and metastasis.
MMP1 plays a key role in tissue remodeling by degrading collagen, a major component of the extracellular matrix, which is essential for processes like wound healing.
MMP1 overexpression is associated with various diseases, including rheumatoid arthritis, atherosclerosis, and certain types of cancer.
High MMP1 levels have been correlated with poor prognosis in certain cancer types, making it a potential biomarker for predicting disease outcomes.
Customer Reviews (3)
Write a reviewThe manufacturer can offer technical support and expertise to guide researchers through the experimental process.
The manufacturer can play a vital role in supporting and optimizing the research process.
This guarantees that the protein is reliable, consistent, and suitable for experiments, reducing variability and enhancing the reproducibility of findings.
Ask a Question for All MMP1 Products
Required fields are marked with *
My Review for All MMP1 Products
Required fields are marked with *