mmp1
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  • Official Full Name
  • matrix metallopeptidase 1 (interstitial collagenase)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
  • Synonyms
  • MMP1; matrix metallopeptidase 1 (interstitial collagenase); CLG; CLGN; interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1
Cat.#:MMP1-5412HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP1 Protein
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Cat.#:MMP1-5413HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MMP1 Protein, GST-tagged
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Cat.#:MMP1-566HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP1 Protein, MYC/DDK-tagged
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Cat.#:MMP1-568HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP1 Protein, His-tagged
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Cat.#:MMP1-149HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Matrix Metallopeptidase 1, Hemopexin-like Domain
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Cat.#:MMP1-407HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Matrix Metallopeptidase 1
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Cat.#:MMP1-126HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP1 Protein, His-tagged
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Cat.#:MMP1-1713HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP1
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Cat.#:MMP1-26HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MMP1 protein, His-tagged
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Cat.#:MMP1-445HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human matrix metallopeptidase 1 (interstitial collagenase), His-tagged
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Cat.#:MMP1-809HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP1, His tagged
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Cat.#:MMP1-91HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP1 protein, T7/His-tagged
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Cat.#:Mmp1-726RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp1 protein, His & T7-tagged
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Cat.#:MMP1-724CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle MMP1 protein, His & T7-tagged
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Cat.#:MMP1-45HTag:
Source (Host):Human fibroblastsSpecies:Human
Product nameNative Human MMP-1
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Cat.#:MMP1-2884HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP1 cell lysate
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Cat.#:MMP1-148HTag:N/A
Source (Host):E. coli.Species:Human
Product nameRecombinant Human Matrix Metallopeptidase 1, Catalytic Domain
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Involved Pathway

MMP1 involved in several pathways and played different roles in them. We selected most pathways MMP1 participated on our site, such as PPAR signaling pathway, Pathways in cancer, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
RXRG; PCK1; CYP8B1; ACSL5; PDPK1B; CYP27A1; SCP2A; PPARDB; SLC27A2; APOA2
Pathways in cancer
ARHGEF12; IGF1R; PIK3CD; IGF1; PDGFRA; ITGA6; STAT5B; FGF18; WNT8B; GNB1
Bladder cancer
CDH1; THBS1; E2F3; DAPK1; VEGFA; UPK3A; MMP2; CCND1; CDK4; MAPK3
Rheumatoid arthritis
HLA-DMA; IL23; ATP6V0C; ATP6V1C2; TNFRSF11A; HLA-DRA; IL1B; CCL3; MMP1A; HLA-DMB

Protein Function

MMP1 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP1 itself. We selected most functions MMP1 had, and list some proteins which have the same functions with MMP1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein AKR1C1; SGCA; MFGE8A; TPM4; CCDC167; SLC25A13; PCDH2G10; CD69; GSNB; TBC1D9B
Function endopeptidase activity
Related Protein KLK1B26; APH1C; PARL; KLK1B3; TMEM59; PSMB8; SENP1; NAPSA; PSMA7; PSMB8F
Function metalloendopeptidase activity
Related Protein PAPLN; ADAM18; ECE1; OSGEPL1; FAP; GM12824; XRCC6BP1; MMP17; MEP1A.2; TLL2
Function zinc ion binding
Related Protein MEX3C; NEURL1AB; ADH4; FTR72; APEX2; LNX2; ZDHHC22; CAR7; CRIP1; ADAMTS3

Interacting Protein

MMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP1.
F2R; SOX8

MMP1 Related Articles

Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
Kumar, D; Moore, RM; et al. Decidual GM-CSF is a critical common intermediate necessary for thrombin and TNF induced in-vitro fetal membrane weakening. PLACENTA 35:1049-1056(2014).

MMP1 Related Gene Family

MMPs