MMP1 Protein, matrix metallopeptidase 1 (interstitial collagenase)

MMP1

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MMP1

Official Full Name matrix metallopeptidase 1 (interstitial collagenase)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Synonyms MMP1; matrix metallopeptidase 1 (interstitial collagenase); CLG; CLGN; interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1
    • Species :
    • Cattle
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Human Fibroblasts
    • Insect Cell
    • NSO
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MMP1-126H Recombinant Human MMP1 Protein, His-tagged HEK293 His
    Human MMP1-148H Recombinant Human Matrix Metallopeptidase 1, Catalytic Domain E.coli N/A
    Human MMP1-149H Recombinant Human Matrix Metallopeptidase 1, Hemopexin-like Domain E.coli N/A
    Human MMP1-1713H Recombinant Human MMP1 E.coli N/A
    Human MMP1-26H Recombinant Human MMP1 protein, His-tagged Insect Cell His
    Human MMP1-2884HCL Recombinant Human MMP1 cell lysate Human Cell N/A
    Human MMP1-407H Recombinant Human Matrix Metallopeptidase 1 NSO N/A
    Human MMP1-445H Recombinant Human matrix metallopeptidase 1 (interstitial collagenase), His-tagged E.coli His
    Human MMP1-45H Native Human MMP-1 Human Fibroblasts N/A
    Human MMP1-5412H Recombinant Human MMP1 Protein E.coli N/A
    Human MMP1-5413H Recombinant Human MMP1 Protein, GST-tagged Wheat Germ GST
    Human MMP1-566H Recombinant Human MMP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MMP1-568H Recombinant Human MMP1 Protein, His-tagged E.coli His
    Human MMP1-809H Recombinant Human MMP1 protein, His-tagged HEK293 His
    Human MMP1-91H Recombinant Human MMP1 protein, T7/His-tagged E.coli T7/His
    Rat Mmp1-726R Recombinant Rat Mmp1 protein, His & T7-tagged E.coli His/T7
    Cattle MMP1-724C Recombinant Cattle MMP1 protein, His & T7-tagged E.coli His/T7

    MMP1 involved in several pathways and played different roles in them. We selected most pathways MMP1 participated on our site, such as PPAR signaling pathway, Pathways in cancer, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PPAR signaling pathway PPARG; ACOX1; ACSL1A; ILK; FABP7A; APOA1; CYP27A1; FABP1A; CYP8B1; ACSL4
    Pathways in cancer FZD1; IGF1R; BIRC8; FZD5; PGF; PLCB4; Fasl; FGF17; TGFB1; PRKCA
    Bladder cancer KRAS; TRP53; DAPK3; CCND1; MAP2K2; RASSF1; MMP1A; MAPK1; RPS6KA5; TP53
    Rheumatoid arthritis HLA-DRB3; ATP6V0E1; CD28; Il23a; Il12b; H2-AA; ATP6V1H; CCL3L1; VEGFA; HLA-DRB1; ATP6V1B1

    MMP1 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP1 itself. We selected most functions MMP1 had, and list some proteins which have the same functions with MMP1. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding TLL2; NOTCH3; CAPN2L; GUCA1G; PRSS3; Shh; CSN2; S100A10A; TPD52; CALU
    endopeptidase activity PSMB7; PSMA6; ECE1; PSMB9B; PSMB11; KLK1B4; Ren1; ACE; SENP3A; MMP1
    metalloendopeptidase activity ADAM10A; MMP20; HE1A; MMP15; ADAMDEC1; ADAMTS15A; ADAM22; YME1L1B; ADAM1B; MMP1
    zinc ion binding ZNF92; MUL1B; ZNRD1; PHC2B; CA2; GFI1AA; TRIM35-24; PRICKLE1A; LHX6; ISL2A

    MMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP1.

    F2R; SOX8

    Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
    Kumar, D; Moore, RM; et al. Decidual GM-CSF is a critical common intermediate necessary for thrombin and TNF induced in-vitro fetal membrane weakening. PLACENTA 35:1049-1056(2014).

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