Tnfsf11
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Official Full Name
tumor necrosis factor (ligand) superfamily, member 11
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Overview
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. -
Synonyms
TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; tumor necrosis factor ligand superfamily member 11; OTTHUMP00000018328; OTTHUMP00000178585; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand;
- Recombinant Proteins
- Cell & Tissue Lysates
- Recombinant Antibodies
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Monkey
- Mouse
- Mus musculus (Mouse)
- Rat
- CHO
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293F
- HEK293T
- Human
- Human Cell
- Human Cells
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Nicotiana Benthamiana
- Sf9
- Yeast
- Avi
- Fc
- C
- His
- DYKDDDDK
- Fc|His
- Flag
- GST
- His (Fc)
- His(C
- ter)
- His|GST
- His|T7
- SUMO
- human|IgG1|Fc
- Met
- mFc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- hFc
- rFc
- Involved Pathway
- Protein Function
- Interacting Protein
- Tnfsf11 Related Articles
- Tnfsf11 Related Gene Family
- Tnfsf11 Related Signal Pathway
Tnfsf11 involved in several pathways and played different roles in them. We selected most pathways Tnfsf11 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfsf11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | Ccl12;TNFRSF21;IL9R;TGFBR1;IFN-a;ACVR2B;FLT4;GM13306;IL-15RA |
NF-kappa B signaling pathway | LBP;BCL10;PRKCB;CARD11;MAP3K14;BCL2;LTA;TRADD;PRKCQ |
Osteoclast differentiation | TNF;AKT1;PIK3CD;BLNK;NFATC2;MAP2K1;LILRA3;NFKB1;LILRB1 |
Prolactin signaling pathway | CCND1;SHC4;SOCS4;ELF5;STAT1;SOCS2;PIK3R5;PIK3CD;MAPK11 |
Rheumatoid arthritis | IL18;ANGPT1;HLA-DPA1;MMP3;IFNG;ATP6V1C1;IL11;CCL3L3;TNF |
Tnfsf11 has several biochemical functions, for example, cytokine activity, tumor necrosis factor receptor binding, tumor necrosis factor receptor superfamily binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfsf11 itself. We selected most functions Tnfsf11 had, and list some proteins which have the same functions with Tnfsf11. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | LFT2;GM13288;TNFSF4;IFNA17;CMTM8;IL6;TNFSF10;LEFTY1;CCL20B |
tumor necrosis factor receptor binding | LTB;TRAF6;CD70;TNFSF10L3;ERAP1;TRAF2;TNFSF9;Fasl;TNF |
tumor necrosis factor receptor superfamily binding | TNFSF4;FADD;TNFSF9;TNFSF18;TNFSF11 |
Tnfsf11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfsf11 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfsf11.
MED24; SBF1; DDAH2; PLK1; LMO4; EEF1A1; MBTPS1; EZH2; SNRNP35; ZC3HC1; TRMT2A; BBS10; FAM213B; PHAX; TMOD3; CEP126
- Q&As
- Reviews
Q&As (6)
Ask a questionIt is possible to detect the expression level of TNFSF11 protein to help diagnose tumors and other diseases, and to assess their prognosis and treatment effectiveness.
At present, a variety of drugs have been developed to target TNFSF11 proteins and their related signaling pathways, including inhibiting their expression and inhibiting their binding to receptors, etc., for the treatment of tumors and other bone metabolism-related diseases.
Studies have shown that TNFSF11 proteins can be involved in the regulation of infectious diseases, such as playing a role in some viral infections.
There are differences in the expression of TNFSF11 proteins in different tissues and organs, and they are expressed in tissues and organs such as the immune system, bones, and teeth, and the expression level may be affected by many factors.
Studies have shown that TNFSF11 proteins can be involved in the regulation of autoimmune diseases, such as in autoimmune diseases such as rheumatoid arthritis.
TNFSF11 protein belongs to the TNF superfamily and has certain structural and functional similarities with other members of the TNF superfamily.
Customer Reviews (3)
Write a reviewThe reproducibility of TNFSF11 is so good that the results are highly consistent regardless of the conditions under which the experiment or application is performed, greatly reducing the experimental error.
Green production process of TNFSF11 is highly commendable, which uses the most advanced biotechnology to increase production efficiency and reduce environmental impact.
The short half-life and high clearance of TNFSF11 make it better able to adapt to changing treatment needs and provide patients with more flexible treatment options.
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