tnfsf11
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  • Official Full Name
  • tumor necrosis factor (ligand) superfamily, member 11
  • Background
  • This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
  • Synonyms
  • TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; tumor necrosis factor ligand superfamily member 11; OTTHUMP00000018328; OTTHUMP00000178585; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand
Cat.#:TNFSF11-209HTag:Fc-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11 Protein, Fc-Avi-tagged, Biotinylated
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Cat.#:TNFSF11-394HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11 Protein (Gly 64 - Asp 245), His-tagged
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Cat.#:TNFSF11-395HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11 Protein, Fc-tagged
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Cat.#:TNFSF11-683MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse TNFSF11 Protein
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Cat.#:TNFSF11-2022HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11 Protein, MYC/DDK-tagged
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Cat.#:TNFSF11-2023MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse TNFSF11 Protein, His-tagged
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Cat.#:TNFSF11-2024MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse TNFSF11 Protein
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Cat.#:TNFSF11-2025RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat TNFSF11 Protein
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Cat.#:VEGFA-587HTag:FC/His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11, His-Fc-Tagged
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Cat.#:TNFSF11-117HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11
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Cat.#:TNFSF11-1679HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human TNFSF11
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Cat.#:TNFSF11-P1002HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Osteoprotegerin Ligand
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Cat.#:Tnfsf11-116MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tumor Necrosis Factor (Ligand) Superfamily, Member 11
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Cat.#:TNFSF11-144HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human TNFSF11, His-tagged
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Cat.#:TNFSF11-1564HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human TNFSF11, Active, His-tagged
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Cat.#:TNFSF11-1567HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF11 protein
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Cat.#:TNFSF11-208HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11, Fc tagged
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Cat.#:TNFSF11-251HTag:
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human TNFSF11
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Cat.#:TNFSF11-252HTag:Met
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF11, Met-tagged
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Cat.#:TNFSF11-31288THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF11
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Cat.#:TNFSF11-322HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11, Fc tagged
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Cat.#:TNFSF11-3553HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF11, His-tagged
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Cat.#:TNFSF11-3744HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF11, His-tagged
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Cat.#:TNFSF11-4154HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 11, GST-tagged
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Cat.#:TNFSF11-424HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11, Fc tagged
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Cat.#:TNFSF11-473HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11, FLAG-tagged
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Cat.#:TNFSF11-4744HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 11
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Cat.#:TNFSF11-8548HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11, None tagged
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Cat.#:TNFSF11-873HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11 Protein, His-tagged
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Cat.#:Tnfsf11-192MTag:
Source (Host):Species:Mouse
Product nameRecombinant Mouse TNFSF11
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Cat.#:Tnfsf11-198MTag:
Source (Host):Species:Mouse
Product nameRecombinant Mouse TNFSF11, Fc-tagged
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Cat.#:Tnfsf11-247MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfsf11, Fc-tagged
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Cat.#:Tnfsf11-474MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tumor Necrosis Factor (Ligand) Superfamily, Member 11
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Cat.#:Tnfsf11-528MTag:His
Source (Host):HEK293FSpecies:Mouse
Product nameRecombinant Mouse Tnfsf11 protein, His-tagged
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Cat.#:Tnfsf11-7835MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfsf11 protein, His & GST-tagged
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Cat.#:TNFSF11-860MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TNFSF11 Protein, Fc-tagged
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Cat.#:Tnfsf11-953MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Tnfsf11 Protein, His-tagged
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Cat.#:Tnfsf11-196RTag:His
Source (Host):CHOSpecies:Rat
Product nameRecombinant Rat Tnfsf11 protein, His-tagged
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Cat.#:TNFSF11-59RTag:
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat TNFSF11 (RANKL)
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Cat.#:TNFSF11-6202RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TNFSF11 Protein
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Cat.#:Tnfsf11-7836RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnfsf11 protein, His & T7-tagged
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Cat.#:TNFSF11-210CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFSF11, Fc-tagged
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Cat.#:TNFSF11-3677CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TNFSF11
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Cat.#:TNFSF11-349HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 11,His-tagged
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Cat.#:Tnfsf11-190MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Tnfsf11, His-tagged
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Cat.#:Tnfsf11-2123MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfsf11, Fc Chimera
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Cat.#:Tnfsf11-2680RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnfsf11
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Cat.#:TNFSF11-1093HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11 cell lysate
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Cat.#:TNFSF11-998HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF11 cell lysate
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Cat.#:TNFSF11-1586MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TNFSF11 cell lysate
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Cat.#:TNFSF11-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFSF11 cell lysate
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Cat.#:CABT-P1009HTag:
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Anti-Human RANKL Monoclonal Antibody
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Involved Pathway

Tnfsf11 involved in several pathways and played different roles in them. We selected most pathways Tnfsf11 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfsf11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL3; Fasl; TNFRSF10A; PDGFAA; CXCL5; IFNA6; IL4; BMP7; CCL27; CXCR1
NF-kappa B signaling pathway
PTGS2; TICAM2; ZAP70; LTA; CARD11; BCL10; LYN; GADD45B; TAB2; MAP3K7
Osteoclast differentiation
PPP3CB; TNFRSF11B; SOCS1; NCF2; AKT1; TAB2; LILRB3; TYK2; RELA; CYBB
Prolactin signaling pathway
STAT5A; MAPK9; PIK3R1; SLC2A2; HRAS; CSH; STAT3; SOCS4; PRL; SHC3
Rheumatoid arthritis
HLA-DQA2; ATP6V0E2; Ctsl; IFNG; ATP6V1C1; ATP6V0A4; HLA-DOB; CCL2; HLA-DQB1; FOS

Protein Function

Tnfsf11 has several biochemical functions, for example, cytokine activity, tumor necrosis factor receptor binding, tumor necrosis factor receptor superfamily binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfsf11 itself. We selected most functions Tnfsf11 had, and list some proteins which have the same functions with Tnfsf11. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein BMP8B; TIMP1; FAM3B; GDF1; VSTM1; GDF10; LFT1; Fasl; GPI1; CMTM1
Function tumor necrosis factor receptor binding
Related Protein TRAP1; TNFSF10L4; TRIM37; FADD; TNFSF13; TNFSF10L3; TNFSF4; TNFSF10; TRAF2; TNFSF12
Function tumor necrosis factor receptor superfamily binding
Related Protein TNFSF4; TNFSF18; TNFSF9; TNFSF11; FADD

Interacting Protein

Tnfsf11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfsf11 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfsf11.
MED24; SBF1; DDAH2; PLK1; LMO4; EEF1A1; MBTPS1; EZH2; SNRNP35; ZC3HC1; TRMT2A; BBS10; FAM213B; PHAX; TMOD3; CEP126

Tnfsf11 Related Articles

Baldo, BA; et al. Adverse events to monoclonal antibodies used for cancer therapy Focus on hypersensitivity responses. ONCOIMMUNOLOGY 2:-(2013).
Pise-Masison, CA; Radonovich, M; et al. Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability. BLOOD 113:4016-4026(2009).

Tnfsf11 Related Gene Family

Cytokines