|Official Full Name||tumor necrosis factor a (TNF superfamily, member 2)|
|Background||Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.|
|Synonyms||TNFa; TNF; tumor necrosis factor (TNF superfamily, member 2); Cachectin; DIF; OTTHUMP00000029281; OTTHUMP00000037669; TNF-a; TNF-alpha; TNFA; TNFSF2; APC1 protein; TNF superfamily, member 2; TNF, macrophage-derived; TNF, monocyte-derived; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor alpha|
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TNFa involved in several pathways and played different roles in them. We selected most pathways TNFa participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
TNFa has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TNFa itself. We selected most functions TNFa had, and list some proteins which have the same functions with TNFa. You can find most of the proteins on our site.
TNFa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFa here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFa.