Recombinant Cynomolgus CD33 Protein, His-tagged, Alexa Fluor 488 conjugated
Cat.No. : | CD33-181CAF488 |
Product Overview : | A DNA sequence encoding the cynomolgus CD33 (XP_005590138.1) (Met1-Gly248) (Alexa Fluor 488 conjugated) was expressed with a polyhistidine tag at the C-terminus. Cynomolgus and Rhesus CD33 sequences are identical. |
Availability | July 26, 2024 |
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Source : | HEK293 |
Species : | Monkey |
Tag : | His |
Form : | Lyophilized |
Molecular Mass : | The recombinant cynomolgus CD33 comprises 244 amino acids and has a calculated molecular mass of 27.3 kDa. The apparent molecular mass of it is approximately 45.2 kDa in SDS-PAGE under reducing condition. |
Protein length : | Met1-Gly248, 244 |
Endotoxin : | < 1.0 EU/ μg of the protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 488 via amines Excitation Wavelength: 488 nm Emission Wavelength: 515-545 nm |
Stability : | Samples are stable for up to 12 months from date of receipt at -70 centigrade. |
Storage : | Store it under sterile conditions at -70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH7.4. |
Gene Name : | CD33 centigrade D33 molecule [Macaca mulatta(Rhesus monkey) ] |
Official Symbol : | CD33 |
Synonyms : | CD33; CD33 molecule; myeloid cell surface antigen CD33 |
Gene ID : | 719855 |
mRNA Refseq : | XM_001114616 |
Protein Refseq : | XP_001114616 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewQuick dissolution, easy use.
Excellent solubility, no aggregates.
High concentration, very effective.
Q&As (7)
Ask a questionCertain polymorphisms in the CD33 gene can influence its expression on the cell surface, which might affect the efficacy of CD33-targeted therapies.
CD33 is a transmembrane receptor primarily expressed on cells of myeloid lineage and is involved in modulating cellular functions, including the regulation of cellular proliferation and differentiation.
CD33 is predominantly expressed on myeloid cells, especially on immature myeloid cells. Its expression decreases as these cells differentiate and is typically low or absent on lymphoid cells.
CD33 has been targeted for therapeutic antibodies in AML. An example is gemtuzumab ozogamicin, which targets CD33 and delivers a cytotoxic agent specifically to leukemia cells expressing CD33.
While the exact signaling pathways of CD33 are still under investigation, it is believed that CD33 signaling can influence the differentiation and function of myeloid cells, potentially playing a role in immune regulation.
CD33 is commonly expressed on the surface of AML blasts, making it a potential target for therapeutic interventions in AML.
The specific ligands for CD33 are not fully characterized, but it is believed to play a role in cell-cell interactions within the immune system.
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