Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 555 conjugated
Cat.No. : | CD33-176HAF555 |
Product Overview : | Alexa Fluor 555 conjugated recombinant human CD33 (Accession # AAA51948) was produced in Mouse myeloma cell line, NS0-derived. |
Availability | February 12, 2025 |
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Source : | Mammalian cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized |
Bio-activity : | Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. The ED50 for this effect is typically 1-4 μg/mL. |
Molecular Mass : | Recombinant Human CD33, Fc Chimera has a calculated MW of 53.4 kDa (monomer). In SDS-PAGE migrates as 67-85 kDa, reducing conditions. |
N-terminal Sequence Analysis : | Asp 18 |
Purity : | > 90 % by SDS-PAGE and analyzed by silver stain |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 555 via amines With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade). |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Gene Name : | CD33 CD33 molecule [ Homo sapiens ] |
Official Symbol : | CD33 |
Synonyms : | CD33; CD33 molecule; CD33 antigen (gp67); myeloid cell surface antigen CD33; FLJ00391; p67; sialic acid binding Ig like lectin 3; SIGLEC 3; SIGLEC3; gp67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC-3; |
Gene ID : | 945 |
mRNA Refseq : | NM_001082618 |
Protein Refseq : | NP_001076087 |
MIM : | 159590 |
UniProt ID : | P20138 |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewQuick dissolution, easy use.
Excellent solubility, no aggregates.
High concentration, very effective.
Q&As (7)
Ask a questionCertain polymorphisms in the CD33 gene can influence its expression on the cell surface, which might affect the efficacy of CD33-targeted therapies.
CD33 is a transmembrane receptor primarily expressed on cells of myeloid lineage and is involved in modulating cellular functions, including the regulation of cellular proliferation and differentiation.
CD33 is predominantly expressed on myeloid cells, especially on immature myeloid cells. Its expression decreases as these cells differentiate and is typically low or absent on lymphoid cells.
CD33 has been targeted for therapeutic antibodies in AML. An example is gemtuzumab ozogamicin, which targets CD33 and delivers a cytotoxic agent specifically to leukemia cells expressing CD33.
While the exact signaling pathways of CD33 are still under investigation, it is believed that CD33 signaling can influence the differentiation and function of myeloid cells, potentially playing a role in immune regulation.
CD33 is commonly expressed on the surface of AML blasts, making it a potential target for therapeutic interventions in AML.
The specific ligands for CD33 are not fully characterized, but it is believed to play a role in cell-cell interactions within the immune system.
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