Recombinant Full Length Human Myeloid Cell Surface Antigen Cd33(Cd33) Protein, His-Tagged
Cat.No. : | RFL3999HF |
Product Overview : | Recombinant Full Length Human Myeloid cell surface antigen CD33(CD33) Protein (P20138) (18-364aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Homo sapiens (Human) |
Tag : | His |
Form : | Lyophilized powder |
Protein length : | Full Length of Mature Protein (18-364) |
AA Sequence : | DPNFWLQVQESVTVQEGLCVLVPCT FFHPIPYYDKNSPVHGYWFREGAII SRDSPVATNKLDQEVQEETQGRFRL LGDPSRNNCSLSIVDARRRDNGSYF FRMERGSTKYSYKSPQLSVHVTDLT HRPKILIPGTLEPGHSKNLTCSVSW ACEQGTPPIFSWLSAAPTSLGPRTT HSSVLIITPRPQDHGTNLTCQVKFA GAGVTTERTIQLNVTYVPQNPTTGI FPGDGSGKQETRAGVVHGAIGGAGV TALLALCLCLIFFIVKTHRRKAART AVGRNDTHPTTGSASPKHQKKSKLH GPTETSSCSGAAPTVEMDEELHYAS LNFHGMNPSKDTSTEYSEVRTQ |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Applications : | SDS-PAGE |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | CD33 |
Synonyms : | CD33; SIGLEC3; Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD antigen CD33 |
UniProt ID : | P20138 |
Gene Name : | CD33 |
Synonyms : | CD33; SIGLEC3; Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD antigen CD33 |
UniProt ID : | P20138 |
Products Types
◆ Recombinant Protein | ||
Cd33-671R | Recombinant Rat Cd33 Protein, His-tagged | +Inquiry |
CD33-0791H | Recombinant Human CD33 Protein, GST-Tagged | +Inquiry |
CD33-2357H | Recombinant Human CD33 protein(Met1-His259), mFc-tagged | +Inquiry |
Cd33-832M | Recombinant Mouse Cd33 Protein, MYC/DDK-tagged | +Inquiry |
CD33-0790H | Recombinant Human CD33 Protein | +Inquiry |
◆ Lysates | ||
CD33-1808MCL | Recombinant Mouse CD33 cell lysate | +Inquiry |
CD33-978HCL | Recombinant Human CD33 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewQuick dissolution, easy use.
Excellent solubility, no aggregates.
High concentration, very effective.
Q&As (7)
Ask a questionCertain polymorphisms in the CD33 gene can influence its expression on the cell surface, which might affect the efficacy of CD33-targeted therapies.
CD33 is a transmembrane receptor primarily expressed on cells of myeloid lineage and is involved in modulating cellular functions, including the regulation of cellular proliferation and differentiation.
CD33 is predominantly expressed on myeloid cells, especially on immature myeloid cells. Its expression decreases as these cells differentiate and is typically low or absent on lymphoid cells.
CD33 has been targeted for therapeutic antibodies in AML. An example is gemtuzumab ozogamicin, which targets CD33 and delivers a cytotoxic agent specifically to leukemia cells expressing CD33.
While the exact signaling pathways of CD33 are still under investigation, it is believed that CD33 signaling can influence the differentiation and function of myeloid cells, potentially playing a role in immune regulation.
CD33 is commonly expressed on the surface of AML blasts, making it a potential target for therapeutic interventions in AML.
The specific ligands for CD33 are not fully characterized, but it is believed to play a role in cell-cell interactions within the immune system.
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