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Recombinant Mouse Csf1r Protein, Fc-tagged

Cat.No. : Csf1r-376M
Product Overview : Recombinant Mouse Csf1r protein with Fc tag was expressed in HEK293.
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Description : Enables several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of protein phosphorylation; and protein phosphorylation. Located in cell surface and plasma membrane. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor).
Source : HEK293
Species : Mouse
Tag : Fc
Form : Lyophilized
Molecular Mass : 81.8 kDa
Protein length : 977
AA Sequence : MELGPPLVLLLATVWHGQGAPVIEP SGPELVVEPGETVTLRCVSNGSVEW DGPISPYWTLDPESPGSTLTTRNAT FKNTGTYRCTELEDPMAGSTTIHLY VKDPAHSWNLLAQEVTVVEGQEAVL PCLITDPALKDSVSLMREGGRQVLR KTVYFFSPWRGFIIRKAKVLDSNTY VCKTMVNGRESTSTGIWLKVNRVHP EPPQIKLEPSKLVRIRGEAAQIVCS ATNAEVGFNVILKRGDTKLEIPLNS DFQDNYYKKVRALSLNAVDFQDAGI YSCVASNDVGTRTATMNFQVVESAY LNLTSEQSLLQEVSVGDSLILTVHA DAYPSIQHYNWTYLGPFFEDQRKLE FITQRAIYRYTFKLFLNRVKASEAG QYFLMAQNKAGWNNLTFELTLRYPP EVSVTWMPVNGSDVLFCDVSGYPQP SVTWMECRGHTDRCDEAQALQVWND THPEVLSQKPFDKVIIQSQLPIGTL KHNMTYFCKTHNSVGNSSQYFRAVS LGQSKQLPDESLFTPVVVACMSVMS LLVLLLLLLLYKYKQKPKYQVRWKI IERYEGNSYTFIDPTQLPYNEKWEF PRNNLQFGKTLGAGAFGKVVEATAF GLGKEDAVLKVAVKMLKSTAHADEK EALMSELKIMSHLGQHENIVNLLGA CTHGGPVLVITEYCCYGDLLNFLRR KAEAMLGPSLSPGQDSEGDSSYKNI HLEKKYVRRDSGFSSQGVDTYVEMR PVSTSSSDSFFKQDLDKEASRPLEL WDLLHFSSQVAQGMAFLASKNCIHR DVAARNVLLTSGHVAKIGDFGLARD IMNDSNYVVKGNARLPVKWMAPESI FDCVYTVQSDVWSYGILLWEIFSLG LNPYPGILVNNKFYKLVKDGYQMAQ PVFAPKNIYSIMQSCWDLEPTRRPT FQQICFLLQEQARLERRDQDYANLP SSGGSSGSDSGGGSSGGSSSEPEEE SSSEHLACCEPGDIAQPLLQPNNYQ FC
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : Csf1r colony stimulating factor 1 receptor [ Mus musculus (house mouse) ]
Official Symbol : Csf1r
Synonyms : Csf1r; colony stimulating factor 1 receptor; Fms; Fim2; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R; macrophage colony-stimulating factor 1 receptor; Names; CSF-1 receptor; CSF-1-R; c-fms; proto-oncogene c-Fms; proto-oncogene fms; EC 2.7.10.1
Gene ID : 12978
mRNA Refseq : NM_001037859
Protein Refseq : NP_001032948
UniProt ID : P09581

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
01/09/2022

    With its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.

    10/30/2017

      This variety allows me to select the most appropriate option based on the specific requirements of my research.

      03/10/2017

        the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the CSF1R protein, which is essential for obtaining accurate and consistent results.

        Q&As (5)

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        Are there any FDA-approved drugs targeting CSF1R for clinical use? 07/20/2021

        Yes, drugs like pexidartinib have been approved for the treatment of certain rare tumors called tenosynovial giant cell tumors (TGCT) that overexpress CSF1R.

        How can CSF1R inhibitors impact the tumor microenvironment? 10/22/2018

        CSF1R inhibitors can modulate the tumor microenvironment by reducing the number of tumor-associated macrophages and promoting an anti-tumor immune response.

        Can CSF1R inhibitors be used in combination with other cancer treatments? 09/20/2018

        Yes, CSF1R inhibitors are often used in combination with chemotherapy and immunotherapy to enhance treatment effectiveness.

        What are the potential clinical applications of CSF1R inhibitors? 01/21/2017

        CSF1R inhibitors are being investigated for cancer therapy to block tumor-promoting macrophages and slow down cancer progression.

        Can CSF1R inhibitors be used to treat neurodegenerative diseases? 12/04/2016

        Research is ongoing, and CSF1R inhibitors are being explored as a potential therapy for neurodegenerative diseases, but no FDA-approved treatments currently exist.

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