Active Recombinant Mouse Interleukin 27 Receptor, Alpha, Fc-tagged Il27ra-660M

Active Recombinant Mouse Interleukin 27 Receptor, Alpha, Fc-tagged


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Cat.No. : Il27ra-660M Optional Service: Optional requirements on this protein
Product Overview : Recombinant Mouse Il27raprotein was expressed in Murine myeloma cell line with the Fc part of humanIgG1 Pro100-Lys330 (C-terminus) and Gly29-Lys510 (N-terminus).
Description : Il27ra (also knownas WSX1 and TCCR) is an 85-95 kDa member of the type I, group 2 cytokinereceptor family. Mature Il27ra is a type I transmembrane glycoprotein thatcontains a 486 amino acids extracellular region, a 21 aa transmembranesegment and a 92 aa cytoplasmic domain. Consistent with type I cytokinereceptors, the extracellular region contains four positionally conservedcysteine residues, a WSxWS motif (for receptor folding and ligand binding),and three fibronectin type III repeats.
Source : Mammalian cells
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Gly29
Molecular Weight : 80 kDa
Activity : Measuredby its ability to inhibit IL-27-antiviral activity using HepG2 humanhepatocellular carcinoma cells infected with encephalomyocarditis (EMC)virus. Bender H. et al. (2009) Hepatology 50:585. The ED50 forthis effect is typically 2-12 μg/mL.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 105-115kDa, reducing conditions
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100 μg/mL in sterile PBS
Storage : Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : Il27ra interleukin 27 receptor,alpha [ Mus musculus ]
Official Symbol : Il27ra
Synonyms : Il27ra; interleukin27 receptor, alpha; CRL1; Tccr; Wsx1; WSX-1; IL-27R; zcytor1; interleukin-27receptor subunit alpha; IL-27RA; IL-27R-alpha; IL-27R subunit alpha; T cellcytokine receptor; IL-27 receptor subunit alpha; type I T-cell cytokinereceptor; cytokine receptor family, class 1 (WSXWS), member 1
Gene ID : 50931
mRNA Refseq : NM_016671
Protein Refseq : NP_057880
UniProt ID : O70394
Chromosome Location : 8 C3; 8
Function : interleukin-27receptor activity; protein binding; receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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