Active Recombinant Human Il27RA protein(Met1-Arg514), hFc-tagged

• Cat.No.: Il27RA-1629H
• Product Overview: Recombinant Human Il27RA protein(NP_004834.1)(Met1-Arg514), fused with C-terminal hFc tag, was expressed in HEK293.

Specification

• similar: Il27RA
• Alias: IL27RA; interleukin 27 receptor, alpha; interleukin-27 receptor subunit alpha; CRL1; IL 27R; T cell cytokine receptor type 1; TCCR; WSX 1; WSX1; zcytor1; IL-27RA; IL-27R-alpha; IL-27R subunit alpha; cytokine receptor-like 1; class I cytokine receptor; IL-27 receptor subunit alpha; T-cell cytokine receptor type 1; type I T-cell cytokine receptor; IL27R
• Source: HEK293
• Species: Human
• Conjugate: C-hFc
• Tag: Fc
• Protein length: Met1-Arg514
• Form: Lyophilized from sterile PBS, pH 7.4, 8% trehalose, 8% mannitol. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Bioactivity: Measured by its binding ability in a functional ELISA. Immobilized human IL27 at 20 μg/ml (100 μl/well) can bind human IL27Ra with a linear range of 0.064-1.6 μg/ml.
• MolecularMass: The recombinant human IL27Rα/Fc is a disulfide-linked homodimeric protein after removal of the signal peptide. The reduced monomer consists of 722 amino acids and has a predicted molecular mass of 79 kDa. As a result of glycosylation, rh IL27Rα/Fc monomer migrates as an approximately 105-115 kDa band in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
• GeneName: IL27RA interleukin 27 receptor, alpha [ Homo sapiens ]
• GeneNameWeblink: 9466
• OfficialSymbol: Il27RA
• OfficialSymbolWeblink: 9466
• GeneIDWeblink: 9466
• mRNARefseq: NM_004843
• mRNARefseqWeblink: NM_004843.2
• ProteinRefseqWeblink: NP_004834.1
• MIMWeblink: 605350
• UniProtID: Q6UWB1
• UniProtIDWeblink: Q6UWB1
• Synonyms: IL27RA; interleukin 27 receptor, alpha; interleukin-27 receptor subunit alpha; CRL1; IL 27R; T cell cytokine receptor type 1; TCCR; WSX 1; WSX1; zcytor1; IL-27RA; IL-27R-alpha; IL-27R subunit alpha; cytokine receptor-like 1; class I cytokine receptor; IL-27 receptor subunit alpha; T-cell cytokine receptor type 1; type I T-cell cytokine receptor; IL27R
• Gene ID: 9466
• MIM: 605350

Gene Information

• Synonyms: IL27RA; interleukin 27 receptor, alpha; interleukin-27 receptor subunit alpha; CRL1; IL 27R; T cell cytokine receptor type 1; TCCR; WSX 1; WSX1; zcytor1; IL-27RA; IL-27R-alpha; IL-27R subunit alpha; cytokine receptor-like 1; class I cytokine receptor; IL-27 receptor subunit alpha; T-cell cytokine receptor type 1; type I T-cell cytokine receptor; IL27R
• Gene ID: 9466
• MIM: 605350

Reviews

03/19/2022

Good stability, stable structure, not easy to deteriorate.

12/08/2021

The preparation process is very convenient and suitable for novice operators.

02/21/2020

This method is highly sensitive and can detect small amounts of protein.

Q&As

What is the use of Il27ra?

In general, Il27ra should be administered by subcutaneous injection. For specific use, follow your doctor's advice and read the drug label carefully.

What is the action mechanism of Il27ra?

Il27ra regulates the function of immune cells by binding to its receptor, inhibiting inflammatory response and enhancing antiviral ability.

Does the clinical applications of Il27ra?

It is mainly used in clinical treatment of immune-related diseases, such as tumors, autoimmune diseases and so on.

Can Il27ra be used with other drugs?

It can be used in conjunction with other medications in certain cases, but be sure to inform your doctor about the medications you are using to avoid the possibility of drug interactions.

Can Il27ra be used in children?

The use of Il27ra in children is not yet clear, please follow the guidance of your doctor.

What are the side effects of Il27ra?

No significant side effects of recombinant Il27ra have been found, but common adverse reactions such as local reactions and anaphylaxis may occur.