Active Recombinant Mouse Il36g Protein (Gly13-Ser164), C-His tagged, Animal-free, Carrier-free

• Cat.No.: Il36g-81M
• Product Overview: Recombinant Mouse Il36g Protein (Gly13-Ser164) with C-His tag was expressed in E. coli and Animal-free as well as Carrier-free.

Specification

• Description: Interleukin 36 gamma (IL-36 gamma) is a 17.65 kDa cytokine with 159 amino acid residues. IL-36 gamma is a member of the IL-1 family and is mainly expressed in keratinocytes, bronchial epithelial cells, macrophages, and monocyte. This cytokine responds to multiple pathogen-associated molecular patterns (PAMPs) and participates in the inflammatory response. In addition, it also induces the production of pro-inflammatory cytokines like IL-12, IL-1β, IL-6, TNF-α, and IL-23.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Lyophilized
• Bio-activity: Measure by its ability to induce IL-6 secretion in 3T3 cells. The ED50 for this effect is < 15 ng/mL. The specific activity of recombinant mouse IL-36 gamma is > 6 × 10^⁴ IU/mg.
• Molecular Mass: The protein has a calculated MW of 18.27 kDa.
  The protein migrates about 17 kDa under reducing condition (SDS-PAGE analysis).
• Protein length: Gly13-Ser164
• Endotoxin: < 0.1 EU/μg of the protein by the LAL method.
• Purity: >98% as determined by SDS-PAGE analysis.
• Storage: This product is stable after storage at:
  -20 centigrade for 12 months in lyophilized state from date of receipt.
  -20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.

Gene Information

• Gene Name: Il36g interleukin 36G [ Mus musculus (house mouse) ]
• Official Symbol: Il36g
• Synonyms: Il36g; interleukin 36G; If36g; Il1f9; IL-36gamma; interleukin-36 gamma; IL-1F9; interleukin 1 family, member 9
• Gene ID: 215257
• mRNA Refseq: NM_153511
• Protein Refseq: NP_705731
• UniProt ID: Q8R460

Reviews

05/29/2022

When experimenting with IL36G, the results are very reproducible.

04/14/2022

Production process of IL36G products is environmentally friendly and sustainable, in line with the concept of green production.

01/06/2022

IL36G has good solubility and ion exchange ability, which is convenient for subsequent experimental treatment and purification.

Q&As

Can IL36G treat other inflammatory diseases?

It is currently mainly used in the treatment of skin inflammatory diseases, and the therapeutic potential of other inflammatory diseases needs further study.

What are the main application areas of IL36G in scientific research?

It is mainly used in the research of the mechanism of skin inflammation and the development of new drugs.

What is the production process of IL36G?

The production of IL36G usually adopts genetic engineering technology, its genes are introduced into the expression host, and pure is obtained through fermentation, purification and other steps.

What are the advantages of IL36G in the treatment of skin inflammation compared with other drugs?

IL36G can be targeted to inhibit inflammation by directly acting on inflammation-related signaling pathways, which may be more effective than other drugs.

What is the mechanism of action of IL36G?

IL36G activates inflammation-related signaling pathways by binding to its receptors, promoting the activation of immune cells and the release of inflammatory factors.

What are the side effects of IL36G?

The side effects of IL36G may include skin irritation, allergic reactions, etc. The specific side effects can vary from individual to individual.