Active Recombinant Human IL36G protein
|Product Overview :||Recombinant Human IL36 gamma/IL-1F9 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ser18-Asp169) of human Interleukin-36 gamma (Accession #NP_062564.1 ).|
- Gene Information
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|Source :||E. coli|
|Form :||Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.|
|Bio-activity :||1.The NF-kB (Luc) HEK293 Reporter Cell was stimulated with serial dilutions of human IL-36 gamma protein. After 7 hours, 2.5 ng/mL of human IL-36 gamma can effectively activate the NF-κB signaling.
2.Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for for this effect is 101.34-405.36 ng/mL.
|Molecular Mass :||17 kDa|
|Protein Length :||Ser18-Asp169|
|Endotoxin :||< 0.1 EU/μg of the protein by LAL method.|
|Purity :||> 92% by SDS-PAGE.|
|Storage :||Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
|Reconstitution :||Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.|
|Gene Name :||IL36G interleukin 36, gamma [ Homo sapiens ]|
|Official Symbol :||IL36G|
|Synonyms :||IL36G; interleukin 36, gamma; IL1F9, interleukin 1 family, member 9; interleukin-36 gamma; IL 1F9; IL 1H1; IL 1RP2; IL1E; IL1H1; interleukin 1 related protein 2; interleukin 1 epsilon; interleukin 1 homolog 1; IL-1 epsilon; IL-1-epsilon; IL-1(EPSILON); interleukin-1 epsilon; IL-1 related protein 2; IL-1-related protein 2; interleukin-1 homolog 1; interleukin-1 family member 9; interleukin 1 family, member 9; interleukin 1-related protein 2; IL1F9; IL-1F9; IL-1H1; IL1RP2; IL-1RP2;|
|Gene ID :||56300|
|mRNA Refseq :||NM_019618|
|Protein Refseq :||NP_062564|
|UniProt ID :||Q9NZH8|
|IL36G-5235HCL||Recombinant Human IL1F9 293 Cell Lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
It is currently mainly used in the treatment of skin inflammatory diseases, and the therapeutic potential of other inflammatory diseases needs further study.
It is mainly used in the research of the mechanism of skin inflammation and the development of new drugs.
The production of IL36G usually adopts genetic engineering technology, its genes are introduced into the expression host, and pure is obtained through fermentation, purification and other steps.
IL36G can be targeted to inhibit inflammation by directly acting on inflammation-related signaling pathways, which may be more effective than other drugs.
IL36G activates inflammation-related signaling pathways by binding to its receptors, promoting the activation of immune cells and the release of inflammatory factors.
The side effects of IL36G may include skin irritation, allergic reactions, etc. The specific side effects can vary from individual to individual.
Customer Reviews (3)Write a review
During the production process, it is necessary to ensure the correct folding and structure of IL-36G similar to the natural form to ensure its function and biological activity. -
IL-36B is detected under different temperature and time conditions to observe its change in thermal stability. When producing IL-36G, it is necessary to ensure its high purity, that is, the protein does not contain other impurities, to ensure the best function and effect. -
Production of IL-36G is usually carried out by cellular expression systems, such as bacterial or mammalian cells, to produce the protein on a large scale. -
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