Active Recombinant Mouse Il36g Protein, His-Tagged
|Product Overview :||Recombinant mouse Il36g Protein, His-tagged was expressed in E. coli cell|
- Gene Information
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|Description :||The expression of IL-36γ is high in psoriatic plaques and in tissues including epithelial cells. Signaling of IL-36γ through the IL-1Rrp2 receptor, which is mainly expressed on certain dendritic cells. The interaction between the IL-36 ligands and IL-1Rrp2 receptor trigger dendritic cell maturation and activation. IL-36γ also work as an agonist of NF-κB, consequently, stimulate the inflammatory response in bronchial epithelial cells.|
|Source :||Escherichia coli|
|Form :||Lyophilized powder|
|AA Sequence :||MGRETPDFGEVFDLDQQVWIFRNQA LVTVPRSHRVTPVSVTILPCKYPES LEQDKGIAIYLGIQNPDKCLFCKEV NGHPTLLLKEEKILDLYHHP
EPMKPFLFYHTRTGGTSTFESVAFP GHYIASSKTGNPIFLTSKKGEYYNI NFNLDIKS with polyhistidine tag at the C-terminus
|Endotoxin :||<0.1 EU per 1 μg of the protein by the LAL method.|
|Bio-activity :||Measure by its ability to induce IL-6 secretion in 3T3 cells. The ED50 for this effect is <15 ng/mL. The specific activity of recombinant mouse IL-36 gamma is > 6 x 10^4 IU/mg.|
|Purity :||>98% as determined by SDS-PAGE. Ni-NTA chromatography|
|Storage Buffer :||The protein was lyophilized from a solution containing 1X PBS, pH 7.4.|
|Reconstitution :||It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.|
|Storage :||Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.|
|Notes :||Please use within one month after protein reconstitution.|
|Gene Name :||Il36g interleukin 36G [ Mus musculus (house mouse) ]|
|Official Symbol :||Il36g|
|Synonyms :||If36g; Il1f9; IL-36gamma|
|Gene ID :||215257|
|mRNA Refseq :||NM_153511.3|
|Protein Refseq :||NP_705731.2|
|UniProt ID :||Q3U0P4|
|IL36G-5235HCL||Recombinant Human IL1F9 293 Cell Lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
It is currently mainly used in the treatment of skin inflammatory diseases, and the therapeutic potential of other inflammatory diseases needs further study.
It is mainly used in the research of the mechanism of skin inflammation and the development of new drugs.
The production of IL36G usually adopts genetic engineering technology, its genes are introduced into the expression host, and pure is obtained through fermentation, purification and other steps.
IL36G can be targeted to inhibit inflammation by directly acting on inflammation-related signaling pathways, which may be more effective than other drugs.
IL36G activates inflammation-related signaling pathways by binding to its receptors, promoting the activation of immune cells and the release of inflammatory factors.
The side effects of IL36G may include skin irritation, allergic reactions, etc. The specific side effects can vary from individual to individual.
Customer Reviews (3)Write a review
When experimenting with IL36G, the results are very reproducible. -
Production process of IL36G products is environmentally friendly and sustainable, in line with the concept of green production. -
IL36G has good solubility and ion exchange ability, which is convenient for subsequent experimental treatment and purification. -
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