• Official Full Name

    interleukin 5 receptor, alpha

  • Background

    Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.<br/>The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.
  • Synonyms

    IL5RA; interleukin 5 receptor, alpha; IL5R; interleukin-5 receptor subunit alpha; CD125; CDw125; CD125 antigen; IL-5R subunit alpha; IL-5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain; HSIL5R3; MGC26560;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Cell & Tissue Lysates
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Insect Cells
    • Mammalian Cell
    • Mammalian cells
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • C
    • His
    • Myc
    • DDK
    • Fc
    • His (Fc)
    • Avi
    • His|T7
    • human|IgG1|Fc
    • MYC
    • Myc|DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken IL5RA-4581C Recombinant Chicken IL5RA Mammalian Cell His
    Cynomolgus Monkey IL5RA-366C Recombinant Cynomolgus Monkey IL5RA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Cynomolgus Monkey IL5RA-366C-B Recombinant Cynomolgus Monkey IL5RA Protein Pre-coupled Magnetic Beads HEK293
    Cynomolgus Monkey IL5RA-620C Recombinant Cynomolgus IL5RA Protein, His-tagged Mammalian Cell His
    Human IL5RA-2094H Recombinant Human IL5RA Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL5RA-3834H Recombinant Human IL5RA, His tagged Human Cell His
    Human IL5RA-334H Recombinant Human IL5RA Protein, His-tagged HEK293 His
    Human IL5RA-125H Recombinant Human IL5RA protein, His-tagged HEK293 His
    Human IL5RA-344HB Recombinant Human IL5RA protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL5RA-251H Recombinant Human IL5RA Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human IL5RA-069H Recombinant Human IL5RA Protein, C-His-tagged E.coli C-His
    Human IL5RA-340H Recombinant Human IL5RA protein, His-Avi-tagged HEK293 His-Avi
    Human IL5RA-241I Recombinant Human IL5RA Protein CHO
    Human IL5RA-27608TH Recombinant Human IL5RA N/A
    Human IL5RA-1646H Recombinant Human Interleukin 5 Receptor, Alpha Sf21 Insect Cell N/A
    Human IL5RA-2060HCL Recombinant Human IL5RA cell lysate Human Cell N/A
    Human IL5RA-126H Recombinant Human Interleukin 5 receptor, Alpha, 308aa, Fc Chimera HEK293 Fc
    Human IL5RA-28136TH Recombinant Human IL5RA, Fc-tagged Fc
    Human IL5RA-127H Active Recombinant Human Interleukin 5 Receptor, Alpha, 322aa, Fc Chimera HEK293 Fc
    Human IL5RA-0180H Recombinant Human IL5RA protein, Fc-tagged HEK293 Fc
    Human IL5RA-45H Recombinant Human IL5RA protein, His-tagged E.coli His
    Human IL5RA-5176H Recombinant Human IL5RA Protein Wheat Germ N/A
    Human IL5RA-327H Recombinant Human IL5RA protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse Il5ra-7244M Recombinant Mouse Il5ra Protein, His-tagged His
    Mouse IL5RA-001MCL Recombinant Mouse IL5RA cell lysate Insect Cell N/A
    Mouse Il5ra-77M Recombinant Mouse Il5ra Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il5ra-1245M Recombinant Mouse Il5ra Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse IL5Ra-431M Recombinant Mouse IL5Ra protein, His-tagged Insect Cells His
    Mouse Il5ra-64M Recombinant Mouse Il5ra Protein, His-tagged Insect Cell His
    Mouse Il5ra-77M-B Recombinant Mouse Il5ra Protein Pre-coupled Magnetic Beads HEK293
    Mouse Il5ra-7064M Recombinant Mouse Il5ra protein, His & T7-tagged E.coli His/T7
    Mouse Il5ra-5663M Active Recombinant Mouse Interleukin 5 Receptor, Alpha, Fc-tagged Mammalian cells Fc
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL5RA Related Articles
    • IL5RA Related Gene Family
    • IL5RA Related Research Area

    IL5RA involved in several pathways and played different roles in them. We selected most pathways IL5RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL5RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionPdgfa&amp;Pdgfb;CCL3L3;Ccl9;INHBA;Ccl21a;CCL22;CCR9A;BMPR1B;LTBR
    Jak-STAT signaling pathwayIFNA17;PTPN2A;IFNA14;CSH2;AKT1;SOCS1;IL11RA;STAM;SOCS3
    Hematopoietic cell lineageCSF3R;Il4ra;ITGA4;IL7;GP9;ITGA3;CD33;CD1D2;IL11RA2

    IL5RA has several biochemical functions, for example, interleukin-5 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL5RA itself. We selected most functions IL5RA had, and list some proteins which have the same functions with IL5RA. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-5 receptor activity
    protein bindingTLE4;CHRNA5;RHOT2;GNG5;CCDC22;TMED10;NELL1;PPP1R13L;FBXO34

    IL5RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL5RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL5RA.

    IL5; CSF2RB; GRB2

    Losol, P; Kim, SH; et al. A genetic effect of IL-5 receptor alpha polymorphism in patients with aspirin-exacerbated respiratory disease. EXPERIMENTAL AND MOLECULAR MEDICINE 45:-(2013).
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    What are the clinical applications of IL5RA? 10/20/2022

    Recombinant IL5RA can be used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. It can reduce the frequency and severity of asthma attacks by blocking the signaling of interleukin 5.

    Can recombinant IL5RA be used to treat other diseases? 06/03/2022

    Currently, recombinant IL5RA is mainly used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. For other diseases, the suitability of IL5RA is subject to further research and clinical trials.

    Does the use of IL5RA require blood routine examination? 12/10/2020

    During the use of IL5RA, the doctor may ask to check the patient's blood routine regularly to monitor changes in blood counts and related indicators. This helps to evaluate the efficacy of the treatment and the safety of the patient.

    Does IL5RA cause dependence? 10/26/2019

    There is no clear evidence that long-term use of recombinant IL5RA causes dependence. For patients using IL5RA, it is best to treat and discontinue the drug according to the advice and guidance of their doctor.

    What is the use of IL5RA? 10/22/2019

    IL5RA is generally administered by subcutaneous injection. The specific use method and dosage should be determined according to the doctor's recommendation and the specific situation of the patient.

    What are the side effects of IL5RA? 06/18/2019

    Common side effects of recombinant IL5RA include pain at the injection site, redness and swelling at the injection site, cough, and sore throat. A small number of patients may experience allergic reactions or serious adverse reactions, so close monitoring of the patient's condition and signs is required when using.

    Customer Reviews (3)

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      The crystal structure of IL5RA was analyzed by X-ray diffraction technique to reveal its three-dimensional structure and important information such as receptor binding site. -


        Biological function and activity of IL5RA were evaluated by cell culture experiment and ELISA. -


          The structure and stability of IL5RA were evaluated by measuring the fluorescence characteristics of IL5RA at different wavelengths. -

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