• Official Full Name

    interleukin 5 receptor, alpha

  • Overview

    Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.<br/>The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.
  • Synonyms

    IL5RA; interleukin 5 receptor, alpha; IL5R; interleukin-5 receptor subunit alpha; CD125; CDw125; CD125 antigen; IL-5R subunit alpha; IL-5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain; HSIL5R3; MGC26560;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • C
  • 6×His
  • His
  • Myc
  • DDK
  • Fc
  • His (Fc)
  • Avi
  • His|T7
  • human|IgG1|Fc
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL5RA-127H Active Recombinant Human Interleukin 5 Receptor, Alpha, 322aa, Fc Chimera HEK293 Fc
Human IL5RA-27608TH Recombinant Human IL5RA N/A
Human IL5RA-1646H Recombinant Human Interleukin 5 Receptor, Alpha Sf21 Insect Cell N/A
Human IL5RA-3834H Active Recombinant Human IL5RA protein, His-tagged HEK293 His Met1-Arg335
Human IL5RA-126H Recombinant Human Interleukin 5 receptor, Alpha, 308aa, Fc Chimera HEK293 Fc
Human IL5RA-28136TH Recombinant Human IL5RA, Fc-tagged Fc
Human IL5RA-45H Recombinant Human IL5RA protein, His-tagged E.coli His
Human IL5RA-125H Recombinant Human IL5RA protein, His-tagged HEK293 His 315
Human IL5RA-2060HCL Recombinant Human IL5RA cell lysate Human Cell N/A
Human IL5RA-2094H Recombinant Human IL5RA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IL5RA-251H Recombinant Human IL5RA Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human IL5RA-069H Recombinant Human IL5RA Protein, C-His-tagged E.coli C-His
Human IL5RA-340H Recombinant Human IL5RA protein, His-Avi-tagged HEK293 His-Avi It contains Asp21-Glu335.
Human IL5RA-344HB Recombinant Human IL5RA protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Asp21-Glu335
Human IL5RA-5687HF Recombinant Full Length Human IL5RA Protein In Vitro Cell Free System 870 amino acids
Human IL5RA-334H Recombinant Human IL5RA Protein, His-tagged HEK293 His 420
Human IL5RA-0180H Active Recombinant Human IL5RA protein, Fc-tagged HEK293 Fc Asp21-Trp342
Human IL5RA-241I Active Recombinant Human IL5RA Protein CHO
Human IL5RA-250H Recombinant Human IL5RA Protein (Asp21-Pro338), C-6×His-tagged HEK293 C-6×His Asp21-Pro338
Human IL5RA-5176H Recombinant Human IL5RA Protein Wheat Germ N/A
Human IL5RA-4283H Recombinant Human IL5RA Protein (Met1-Glu335), C-His tagged Mammalian cells C-His Met1-Glu335
Human IL5RA-327H Recombinant Human IL5RA protein, Fc-tagged HEK293 human/IgG1/Fc 322
Mouse Il5ra-5663M Active Recombinant Mouse Interleukin 5 Receptor, Alpha, Fc-tagged Mammalian cells Fc
Mouse IL5Ra-431M Recombinant Mouse IL5Ra protein, His-tagged Insect Cells His Met1-Val328
Mouse Il5ra-64M Recombinant Mouse Il5ra Protein, His-tagged Insect Cell His
Mouse Il5ra-7064M Recombinant Mouse Il5ra protein, His & T7-tagged E.coli His/T7 Ala41~Lys203 (Accession # P21183)
Mouse IL5RA-001MCL Recombinant Mouse IL5RA cell lysate Insect Cell N/A
Mouse Il5ra-77M Recombinant Mouse Il5ra Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il5ra-1245M Recombinant Mouse Il5ra Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Il5ra-7244M Recombinant Mouse Il5ra Protein, His-tagged His 18-339
Mouse Il5ra-77M-B Recombinant Mouse Il5ra Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey IL5RA-620C Recombinant Cynomolgus IL5RA Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey IL5RA-366C Recombinant Cynomolgus Monkey IL5RA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey IL5RA-366C-B Recombinant Cynomolgus Monkey IL5RA Protein Pre-coupled Magnetic Beads HEK293
Mus musculus (Mouse) RFL23168MF Recombinant Full Length Mouse Interleukin-5 Receptor Subunit Alpha(Il5Ra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (18-415)
Chicken IL5RA-4581C Recombinant Chicken IL5RA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL5RA involved in several pathways and played different roles in them. We selected most pathways IL5RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL5RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCR3.1;CXCL1;IL12RB2;CCL21B;TNFSF11;ACVR1BA;TNFRSF11B;LEPB;TGFB2
Jak-STAT signaling pathwayIL21R;PIM1;SOCS7;IL22RA1;CCND1;BCL2;PIK3R3A;IL10RB;IL2RA
Hematopoietic cell lineageTNF;FLT3;Flt3l;IL11RA;GP1BB;IL7;GP1BA;ITGA4;GM13305

IL5RA has several biochemical functions, for example, interleukin-5 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL5RA itself. We selected most functions IL5RA had, and list some proteins which have the same functions with IL5RA. You can find most of the proteins on our site.

Function Related Protein
interleukin-5 receptor activity
protein bindingUBA7;C19orf10;MARVELD3;LRRC4;NUP35;ST6GAL1;SCUBE3;TSPAN6;BSG

IL5RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL5RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL5RA.


Gene Family


Research Area

Related articles

Losol, P; Kim, SH; et al. A genetic effect of IL-5 receptor alpha polymorphism in patients with aspirin-exacerbated respiratory disease. EXPERIMENTAL AND MOLECULAR MEDICINE 45:-(2013).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What are the clinical applications of IL5RA? 10/20/2022

Recombinant IL5RA can be used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. It can reduce the frequency and severity of asthma attacks by blocking the signaling of interleukin 5.

Can recombinant IL5RA be used to treat other diseases? 06/03/2022

Currently, recombinant IL5RA is mainly used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. For other diseases, the suitability of IL5RA is subject to further research and clinical trials.

Does the use of IL5RA require blood routine examination? 12/10/2020

During the use of IL5RA, the doctor may ask to check the patient's blood routine regularly to monitor changes in blood counts and related indicators. This helps to evaluate the efficacy of the treatment and the safety of the patient.

Does IL5RA cause dependence? 10/26/2019

There is no clear evidence that long-term use of recombinant IL5RA causes dependence. For patients using IL5RA, it is best to treat and discontinue the drug according to the advice and guidance of their doctor.

What is the use of IL5RA? 10/22/2019

IL5RA is generally administered by subcutaneous injection. The specific use method and dosage should be determined according to the doctor's recommendation and the specific situation of the patient.

What are the side effects of IL5RA? 06/18/2019

Common side effects of recombinant IL5RA include pain at the injection site, redness and swelling at the injection site, cough, and sore throat. A small number of patients may experience allergic reactions or serious adverse reactions, so close monitoring of the patient's condition and signs is required when using.

Customer Reviews (3)

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    Good stability under different temperature and humidity conditions.


      In the process of purification, the removal of impurities is good.


        Chemical modifications, such as PEGylation or glycosylation, have little effect.

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