IL5RA Protein


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Official Full Name interleukin 5 receptor, alpha
Background Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.<br/>The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.
Synonyms IL5RA; interleukin 5 receptor, alpha; IL5R; interleukin-5 receptor subunit alpha; CD125; CDw125; CD125 antigen; IL-5R subunit alpha; IL-5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain; HSIL5R3; MGC26560
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Source :
    • CHO
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293T
    • Human Cell
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • Fc
    • His
    • T7
    • His-Avi
    • human
    • IgG1
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL5RA-127H Active Recombinant Human Interleukin 5 Receptor, Alpha, 322aa, Fc Chimera HEK293 Fc Inquiry
    Mouse Il5ra-5663M Active Recombinant Mouse Interleukin 5 Receptor, Alpha, Fc-tagged Mammalian cells Fc Inquiry
    Human IL5RA-45H Recombinant Human IL5RA protein, His-tagged E.coli His Inquiry
    Human IL5RA-125H Recombinant Human IL5RA protein, His-tagged HEK293 His Inquiry
    Human IL5RA-126H Recombinant Human Interleukin 5 receptor, Alpha, 308aa, Fc Chimera HEK293 Fc Inquiry
    Human IL5RA-1646H Recombinant Human Interleukin 5 Receptor, Alpha Sf21 Insect Cell N/A Inquiry
    Human IL5RA-27608TH Recombinant Human IL5RA N/A Inquiry
    Human IL5RA-28136TH Recombinant Human IL5RA, Fc-tagged Fc Inquiry
    Human IL5RA-3834H Recombinant Human IL5RA, His tagged Human Cell His Inquiry
    Mouse IL5Ra-431M Recombinant Mouse Il5ra, His tagged Insect Cell Fc/His Inquiry
    Mouse Il5ra-64M Recombinant Mouse Il5ra Protein, His-tagged Insect Cell His Inquiry
    Mouse Il5ra-7064M Recombinant Mouse Il5ra protein, His & T7-tagged E.coli His/T7 Inquiry
    Cynomolgus Monkey IL5RA-620C Recombinant Cynomolgus IL5RA Protein, His-tagged Mammalian Cell His Inquiry
    Chicken IL5RA-4581C Recombinant Chicken IL5RA Mammalian Cell His Inquiry
    Human IL5RA-2060HCL Recombinant Human IL5RA cell lysate Human Cell N/A Inquiry
    Mouse IL5RA-001MCL Recombinant Mouse IL5RA cell lysate Insect Cell N/A Inquiry
    Human IL5RA-241I Recombinant Human IL5RA Protein CHO Inquiry
    Human IL5RA-5687HF Recombinant Full Length Human IL5RA Protein In Vitro Cell Free System Inquiry
    Mus musculus (Mouse) RFL23168MF Recombinant Full Length Mouse Interleukin-5 Receptor Subunit Alpha(Il5Ra) Protein, His-Tagged E.coli expression system His Inquiry
    Human IL5RA-2094H Recombinant Human IL5RA Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human IL5RA-251H Recombinant Human IL5RA Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK Inquiry
    Human IL5RA-327H Recombinant Human IL5RA protein, Fc-tagged HEK293 human/IgG1/Fc Inquiry
    Human IL5RA-340H Recombinant Human IL5RA protein, His-Avi-tagged HEK293 His-Avi Inquiry
    Human IL5RA-344HB Recombinant Human IL5RA protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Inquiry
    Human IL5RA-5176H Recombinant Human IL5RA Protein Wheat Germ N/A Inquiry
    Mouse Il5ra-1245M Recombinant Mouse Il5ra Protein, MYC/DDK-tagged HEK293T MYC/DDK Inquiry
    Mouse Il5ra-7244M Recombinant Mouse Il5ra Protein, His-tagged His Inquiry

    IL5RA involved in several pathways and played different roles in them. We selected most pathways IL5RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL5RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL13; INHBA; GM1987; CCL28; IL11RA2; IL18; CXCL9; IFNPHI1; Fasl; Il2
    Jak-STAT signaling pathway GM2002; STAT1A; TYK2; Il23a; IL23R; IL2RB; AKT3A; AOX2P; SOCS6B; IFNA13
    Hematopoietic cell lineage CD8A; IL2RA; IL4R; CSF1R; FLT3; CD1D2; GYPA; THPO; ITGA5; Cd24a

    IL5RA has several biochemical functions, for example, interleukin-5 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL5RA itself. We selected most functions IL5RA had, and list some proteins which have the same functions with IL5RA. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-5 receptor activity IL5RA
    protein binding FAM134B; LTBP1; CSTF2T; CNOT3; CDC25B; PRCC; TBC1D2; DDX21; CBLB; SSBP3

    IL5RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL5RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL5RA.

    IL5; CSF2RB; GRB2

    Losol, P; Kim, SH; et al. A genetic effect of IL-5 receptor alpha polymorphism in patients with aspirin-exacerbated respiratory disease. EXPERIMENTAL AND MOLECULAR MEDICINE 45:-(2013).

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