IL5RA
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Official Full Name
interleukin 5 receptor, alpha
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Background
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.<br/>The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. -
Synonyms
IL5RA; interleukin 5 receptor, alpha; IL5R; interleukin-5 receptor subunit alpha; CD125; CDw125; CD125 antigen; IL-5R subunit alpha; IL-5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain; HSIL5R3; MGC26560;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL5RA Related Articles
- IL5RA Related Gene Family
- IL5RA Related Research Area
IL5RA involved in several pathways and played different roles in them. We selected most pathways IL5RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL5RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | Pdgfa&Pdgfb;CCL3L3;Ccl9;INHBA;Ccl21a;CCL22;CCR9A;BMPR1B;LTBR |
| Jak-STAT signaling pathway | IFNA17;PTPN2A;IFNA14;CSH2;AKT1;SOCS1;IL11RA;STAM;SOCS3 |
| Hematopoietic cell lineage | CSF3R;Il4ra;ITGA4;IL7;GP9;ITGA3;CD33;CD1D2;IL11RA2 |
IL5RA has several biochemical functions, for example, interleukin-5 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL5RA itself. We selected most functions IL5RA had, and list some proteins which have the same functions with IL5RA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-5 receptor activity | |
| protein binding | TLE4;CHRNA5;RHOT2;GNG5;CCDC22;TMED10;NELL1;PPP1R13L;FBXO34 |
IL5RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL5RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL5RA.
IL5; CSF2RB; GRB2
- Q&As
- Reviews
Q&As (6)
Ask a questionRecombinant IL5RA can be used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. It can reduce the frequency and severity of asthma attacks by blocking the signaling of interleukin 5.
Currently, recombinant IL5RA is mainly used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. For other diseases, the suitability of IL5RA is subject to further research and clinical trials.
During the use of IL5RA, the doctor may ask to check the patient's blood routine regularly to monitor changes in blood counts and related indicators. This helps to evaluate the efficacy of the treatment and the safety of the patient.
There is no clear evidence that long-term use of recombinant IL5RA causes dependence. For patients using IL5RA, it is best to treat and discontinue the drug according to the advice and guidance of their doctor.
IL5RA is generally administered by subcutaneous injection. The specific use method and dosage should be determined according to the doctor's recommendation and the specific situation of the patient.
Common side effects of recombinant IL5RA include pain at the injection site, redness and swelling at the injection site, cough, and sore throat. A small number of patients may experience allergic reactions or serious adverse reactions, so close monitoring of the patient's condition and signs is required when using.
Customer Reviews (3)
Write a reviewThe crystal structure of IL5RA was analyzed by X-ray diffraction technique to reveal its three-dimensional structure and important information such as receptor binding site. -
Biological function and activity of IL5RA were evaluated by cell culture experiment and ELISA. -
The structure and stability of IL5RA were evaluated by measuring the fluorescence characteristics of IL5RA at different wavelengths. -
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