| Description : |
Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9). |
| Source : |
HEK293 |
| Species : |
Rat |
| Tag : |
C-6×His |
| Form : |
Liquid |
| Bio-activity : |
Specific activity is > 2,000 pmol/min/μg, and is defined as the amount of enzyme that cleaves 1pmol of Mca-PLGL-Dpa-AR-NH2 per minute at pH 7.5 at 25 centigrade. |
| Molecular Mass : |
77.2kDa (695aa) |
| Protein Length : |
20-708 |
| AA Sequence : |
APHQRQPTYVVFPRDLKTSNLTDTQ LAEDYLYRYGYTRAAQMMGEKQSLR PALLMLQKQLSLPQTGELDSETLKA IRSPRCGVPDVGKFQTFEGDLKWHH HNITYWIQSYTEDLPRDVIDDSFAR AFAVWSAVTPLTFTRVYGLEADIVI QFGVAEHGDGYPFDGKDGLLAHAFP PGPGIQGDAHFDDDELWSLGKGAVV PTYFGNANGAPCHFPFTFEGRSYLS CTTDGRNDGKPWCGTTADYDTDRKY GFCPSENLYTEHGNGDGKPCVFPFI FEGHSYSACTTKGRSDGYRWCATTA NYDQDKLYGFCPTRADVTVTGGNSA GEMCVFPFVFLGKQYSTCTGEGRSD GRLWCATTSNFDADKKWGFCPDQGY SLFLVAAHEFGHALGLDHSSVPEAL MYPMYHYHEDSPLHEDDIKGIQHLY GRGSKPDPRPPATTAAEPQPTAPPT MCPTAPPMAYPTGGPTVAPTGAPSP GPTGPPTAGPSEAPTESSTPVDNPC NVDVFDAIADIQGALHFFKDGRYWK FSNHGGSQLQGPFLIARTWPALPAK LNSAFEDPQSKKIFFFSGRKMWVYT GQTVLGPRSLDKLGLGSEVTLVTGL LPRRGGKALLISRERIWKFDLKSQK VDPQSVTRLDNEFSGVPWNSHNVFH YQDKAYFCHDKYFWRVSFHNRVNQV DHVAYVTYDLLQCP |
| Endotoxin : |
<1.0 EU/μg of the protein by the LAL method. |
| Purity : |
>90% by SDS-PAGE |
| Applications : |
SDS-PAGE, Enzyme Activity |
| Storage : |
Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
| Concentration : |
0.5 mg/mL (determined by Absorbance at 280nm) |
| Storage Buffer : |
20mM Tris-HCl (pH 7.5) containing 1mM CaCl2, 100mM NaCl, 10% glycerol |
