Recombinant Full Length Human MMP9 Protein, GST-tagged

• Cat.No.: MMP9-6282HF
• Product Overview: Human MMP9 full-length ORF ( AAH06093.1, 1 a.a. - 707 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 103.4 kDa
• Protein Length: 707 amino acids
• AA Sequence: MSLWQPLVLVLLVLGCCFAAPRQRQ STLVLFPGDLRTNLTDRQLAEEYLY RYGYTRVAEMRGESKSLGPALLLLQ KQLSLPETGELDSATLKAMRTPRCG VPDLGRFQTFEGDLKWHHHNITYWI QNYSEDLPRAVIDDAFARAFALWSA VTPLTFTRVYSRDADIVIQFGVAEH GDGYPFDGKDGLLAHAFPPGPGIQG DAHFDDDELWSLGKGVVVPTRFGNA DGAACHFPFIFEGRSYSACTTDGRS DGLPWCSTTANYDTDDRFGFCPSER LYTRDGNADGKPCQFPFIFQGQSYS ACTTDGRSDGYRWCATTANYDRDKL FGFCPTRADSTVMGGNSAGELCVFP FTFLGKEYSTCTSEGRGDGRLWCAT TSNFDSDKKWGFCPDQGYSLFLVAA HEFGHALGLDHSSVPEALMYPMYRF TEGPPLHKDDVNGIRHLYGPRPEPE PRPPTTTTPQPTAPPTVCPTGPPTV HPSERPTAGPTGPPSAGPTGPPTAG PSTATTVPLSPVDDACNVNIFDAIA EIGNQLYLFKDGKYWRFSEGRGSRP QGPFLIADKWPALPRKLDSVFEEPL SKKLFFFSGRQVWVYTGASVLGPRR LDKLGLGADVAQVTGALRSGRGKML LFSGRRLWRFDVKAQMVDPRSASEV DRMFPGVPLDTHDVFQYREKAYFCQ DRFYWRVSSRSELNQVDQVGYVTYD ILQCPED
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) [ Homo sapiens ]
• Official Symbol: MMP9
• Synonyms: MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); CLG4B, matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase) , matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase-9; 92 kDa gelatinase; type V collagenase; macrophage gelatinase; 92 kDa type IV collagenase; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); GELB; CLG4B; MMP-9; MANDP2
• Gene ID: 4318
• mRNA Refseq: NM_004994
• Protein Refseq: NP_004985
• MIM: 120361
• UniProt ID: P14780

Reviews

05/03/2020

The superior quality of this recombined protein has significantly enhanced the precision of our research outcomes.

08/15/2019

Fast shipping! Ordered this product, and it arrived well-packaged and ready for use in our experiments.

01/21/2018

Customer service went above and beyond to accommodate our specific needs, ensuring a smooth purchasing experience.

Q&As

What are the consequences of dysregulated MMP9 expression in cancer progression?

Dysregulated MMP9 expression is associated with cancer invasion and metastasis, as it enables tumor cells to degrade the extracellular matrix and invade surrounding tissues.

What is the impact of MMP9 polymorphisms on enzyme activity?

Polymorphisms in the MMP9 gene can influence enzyme activity, potentially affecting the individual's susceptibility to certain diseases and the progression of pathological conditions.

Can you explain the role of MMP9 in tissue remodeling at the molecular level?

MMP9 facilitates tissue remodeling by cleaving structural proteins in the extracellular matrix, such as collagen and gelatin, leading to changes in tissue architecture.

What is the role of MMP9 in the breakdown of the blood-brain barrier during neurological disorders?

MMP9 contributes to the breakdown of the blood-brain barrier by degrading tight junction proteins, potentially exacerbating neurological disorders and neuroinflammation.

How does MMP9 contribute to angiogenesis at the molecular level?

MMP9 plays a role in angiogenesis by promoting the release and activation of growth factors sequestered in the extracellular matrix, facilitating the formation of new blood vessels.