Active Recombinant Mouse Mmp9 Protein, His-tagged

• Cat.No.: Mmp9-561M
• Product Overview: Recombinant Mouse Mmp9 fused with His tag at N-terminal was expressed in HEK293.

Specification

• Description: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis.
• Source: HEK293
• Species: Mouse
• Tag: His
• Form: 25 mM TRIS, 10 mM CaCl2, 150 mM NaCl, pH7.5
• Bio-activity: Mouse MMP-9 cleaves the peptide substrate Mca-PLGL(Dpa)AR with a specific activity value higher than 1000 pmol/µg/min after activation.
• Molecular Mass: 81 kDa
• Endotoxin: Less than 1 ng per µg protein as determine by the LAL method.
• Purity: >90%, as determined by Coomassie stained SDS-PAGE.
• Concentration: Protein formulated and vialed at >50 ug/mL in specified buffer

Gene Information

• Gene Name: Mmp9 matrix metallopeptidase 9 [ Mus musculus ]
• Official Symbol: Mmp9
• Synonyms: MMP9; matrix metallopeptidase 9; matrix metalloproteinase-9; GELB; Gel B; gelatinase B; 92kD gelatinase; 92kDa gelatinase; 92 kDa gelatinase; collagenase type IVB; 92kD type IV collagenase; 92kDa type IV collagenase; 92 kDa type IV collagenase; matrix metalloproteinase 9; Clg4b; MMP-9; B/MMP9; AW743869; pro-MMP-9
• Gene ID: 17395
• mRNA Refseq: NM_013599
• Protein Refseq: NP_038627

Reviews

05/03/2020

The superior quality of this recombined protein has significantly enhanced the precision of our research outcomes.

08/15/2019

Fast shipping! Ordered this product, and it arrived well-packaged and ready for use in our experiments.

01/21/2018

Customer service went above and beyond to accommodate our specific needs, ensuring a smooth purchasing experience.

Q&As

What are the consequences of dysregulated MMP9 expression in cancer progression?

Dysregulated MMP9 expression is associated with cancer invasion and metastasis, as it enables tumor cells to degrade the extracellular matrix and invade surrounding tissues.

What is the impact of MMP9 polymorphisms on enzyme activity?

Polymorphisms in the MMP9 gene can influence enzyme activity, potentially affecting the individual's susceptibility to certain diseases and the progression of pathological conditions.

Can you explain the role of MMP9 in tissue remodeling at the molecular level?

MMP9 facilitates tissue remodeling by cleaving structural proteins in the extracellular matrix, such as collagen and gelatin, leading to changes in tissue architecture.

What is the role of MMP9 in the breakdown of the blood-brain barrier during neurological disorders?

MMP9 contributes to the breakdown of the blood-brain barrier by degrading tight junction proteins, potentially exacerbating neurological disorders and neuroinflammation.

How does MMP9 contribute to angiogenesis at the molecular level?

MMP9 plays a role in angiogenesis by promoting the release and activation of growth factors sequestered in the extracellular matrix, facilitating the formation of new blood vessels.