MS4A1

  • Official Full Name

    membrane-spanning 4-domains, subfamily A, member 1

  • Overview

    This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
  • Synonyms

    MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cynomolgus
  • Cynomolgus Monkey
  • Dog
  • Ferret
  • Homo sapiens (Human)
  • Human
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Baculovirus-Insect cells
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In vitro E. coli expression system
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Biotin|Fc
  • Fc
  • Flag
  • Flag,8His
  • GFP
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • His|trxA
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • 8×His
  • TEV
  • Trx
  • TrxA
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MS4A1-17H Active Recombinant Human MS4A1 protein, Fc-tagged HEK293 Fc
Human MS4A1-19H Active Recombinant Human MS4A1 Protein, TrxA-tagged E.coli TrxA
Human MS4A1-17HAF488 Active Recombinant Human MS4A1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Human MS4A1-470H Active Recombinant Human MS4A1 Protein (Ile141-Ser188), TrxA-tagged, Biotinylated E.coli TrxA
Human MS4A1-17HAF647 Active Recombinant Human MS4A1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Human MS4A1-17HAF555 Active Recombinant Human MS4A1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Human MS4A1-151H Active Recombinant Human MS4A1 protein, Flag-tagged HEK293 Flag
Human MS4A1-17HF Active Recombinant Human MS4A1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Human MS4A1-11H Recombinant Human MS4A1 Wheat Germ N/A
Human MS4A1-16H Recombinant Human MS4A1, His-tagged E.coli His
Human MS4A1-10H Recombinant Human MS4A1, GST-tagged Wheat Germ GST
Human MS4A1-8530H Recombinant Human MS4A1, His-tagged Human Cell His
Human MS4A1-826H Recombinant Human MS4A1, Biotin-Fc-tagged HEK293 Biotin/Fc
Human MS4A1-18H Recombinant Human MS4A1 protein, His/trxA-tagged E.coli His/trxA
Human MS4A1-22H Recombinant Human MS4A1 Protein (T2-P297 end), N-8×His-Flag-TEV-tagged Insect Cell N-8×His-Flag-TEV
Human MS4A1-1542HCL Recombinant Human MS4A1 cell lysate Human Cell N/A
Human MS4A1-7308HAF555 Recombinant Human MS4A1 Protein, His-tagged, Alexa Fluor 555 conjugated His
Human MS4A1-1933H Recombinant Human MS4A1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MS4A1-17HP Recombinant Human MS4A1 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human MS4A1-3928H Active Recombinant Human MS4A1 Full Length Transmembrane protein, His-tagged(VLPs) HEK293 His
Human MS4A1-3929H Recombinant Human MS4A1 full length protein, His-tagged(Nanodisc) HEK293 His
Human MS4A1-48392H Active Recombinant Human MS4A1 protein, His-tagged Baculovirus-Insect cells His
Human MS4A1-17HA Recombinant Human MS4A1 protein, Fc-tagged, APC labeled HEK293 Fc
Human MS4A1-420H Recombinant Human MS4A1 protein, His-Avi-tagged E. coli His-Avi
Human MS4A1-3932H Recombinant Human MS4A1 full length protein, His/Avi-tagged, Biotinylated(Nanodisc) HEK293 His/Avi
Human MS4A1-7308HAF647 Recombinant Human MS4A1 Protein, His-tagged, Alexa Fluor 647 conjugated His
Human MS4A1-1135H Recombinant Human MS4A1 Protein, His&GST-tagged E.coli N-His&GST
Human MS4A1-3930H Active Recombinant Human MS4A1 protein HEK293 N/A
Human MS4A1-391H Active Recombinant Fluorescent Human MS4A1 Full Length protein(VLPs), GFP-tagged HEK293 GFP
Human MS4A1-7308HF Recombinant Human MS4A1 Protein, His-tagged, FITC conjugated His
Human MS4A1-5471H Recombinant Human MS4A1 protein, His-tagged Yeast His
Human MS4A1-3931H Active Recombinant Human MS4A1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Human MS4A1-1439H Recombinant Human MS4A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MS4A1-1649H Recombinant Human MS4A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MS4A1-118HFL Recombinant Full Length Human MS4A1 Protein, C-Flag-tagged Mammalian cells Flag
Human MS4A1-7308HAF488 Recombinant Human MS4A1 Protein, His-tagged, Alexa Fluor 488 conjugated His
Human MS4A1-23H Recombinant Human MS4A1 Protein (T2-P297 end), N-8×His-Flag-TEV-tagged Insect Cell N-8×His-Flag-TEV
Human MS4A1-2359H Active Recombinant Human MS4A1 protein, His-Flag-tagged HEK293 His-Flag
Human MS4A1-0157H Recombinant Human MS4A1 Protein (T2-P297 end), Flag, 8×His tagged Insect Cell Flag,8His
Human MS4A1-0767H Recombinant Human MS4A1 Protein (Ile143-Ser188), N-His and N-Trx tagged E.coli N-His and N-Trx
Human MS4A1-1439H-B Recombinant Human MS4A1 Protein Pre-coupled Magnetic Beads HEK293
Human MS4A1-0123H Recombinant Human MS4A1 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His
Human MS4A1-5318H Recombinant Human MS4A1 Protein (Glu213-Pro297), N-His tagged Mammalian cells N-His
Human MS4A1-5319H Recombinant Human MS4A1 Protein (Met1-Pro297), His tagged E.coli His
Mouse Ms4a1-4893M Recombinant Mouse Ms4a1 protein, His/SUMO-tagged E.coli His/SUMO
Mouse MS4A1-10113M Recombinant Mouse MS4A1 Protein Mammalian Cell His
Mouse Ms4a1-4896M Recombinant Mouse Ms4a1 protein, His-tagged Yeast His
Mouse Ms4a1-4899M Recombinant Mouse Ms4a1 protein, His/GST-tagged E.coli His/GST
Mouse MS4A1-5732M-B Recombinant Mouse MS4A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ms4a1-830M Recombinant Mouse Ms4a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse MS4A1-5732M Recombinant Mouse MS4A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ms4a1-5472M Recombinant Mouse Ms4a1 protein, His-tagged Yeast His
Mouse Ms4a1-1136M Recombinant Mouse Ms4a1 Protein, His-tagged E.coli N-His
Monkey MS4A1-62CAF488 Recombinant Cynomolgus MS4A1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Monkey MS4A1-62CAF647 Recombinant Cynomolgus MS4A1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Monkey MS4A1-62CAF555 Recombinant Cynomolgus MS4A1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Monkey MS4A1-62CF Recombinant Cynomolgus MS4A1 Protein, His-tagged, FITC conjugated HEK293 His
Dog MS4A1-6579D Active Recombinant Dog MS4A1 protein, His-tagged(Nanodisc) HEK293 His
Dog MS4A1-6578D Active Recombinant Dog MS4A1 Full Length Transmembrane protein, His-tagged(VLPs) HEK293 His
Dog MS4A1-1934D Recombinant Dog MS4A1 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His
Canine MS4A1-3048C Active Recombinant Canine MS4A1 protein, His-tagged HEK293 His
Canine MS4A1-3049C Active Recombinant Canine MS4A1 protein, His-tagged HEK293 His
Canis lupus familiaris (Dog) (Canis familiaris) RFL16853CF Recombinant Full Length Dog B-Lymphocyte Antigen Cd20(Ms4A1) Protein, His-Tagged E.coli expression system His
Cynomolgus MS4A1-708C Recombinant Cynomolgus MS4A1 protein, His-tagged HEK293 His
Cynomolgus MS4A1-3050C Active Recombinant Cynomolgus MS4A1 Full Length Transmembrane protein, His-tagged(VLPs) HEK293 His
Cynomolgus Monkey MS4A1-62C Recombinant Cynomolgus MS4A1, His tagged Human Cell Fc
Cynomolgus Monkey MS4A1-819CCL Recombinant Cynomolgus MS4A1 cell lysate Human Cell N/A
Ferret MS4A1-09F Recombinant Ferret MS4A1, His tagged Human Cell His
Ferret MS4A1-1848FCL Recombinant Ferret MS4A1 cell lysate Human Cell N/A
Ferret MS4A1-09FAF488 Recombinant Ferret MS4A1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Ferret MS4A1-09FAF555 Recombinant Ferret MS4A1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Ferret MS4A1-09FAF647 Recombinant Ferret MS4A1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Ferret MS4A1-09FF Recombinant Ferret MS4A1 Protein, His-tagged, FITC conjugated HEK293 His
Homo sapiens (Human) RFL14830HF Recombinant Full Length Human B-Lymphocyte Antigen Cd20(Ms4A1)-Vlps (Active) Protein, His-Tagged E.coli expression system His
Homo sapiens (Human) RFL31628HF Recombinant Full Length Human B-Lymphocyte Antigen Cd20(Ms4A1) Protein, His-Tagged E.coli expression system His
Mus musculus (Mouse) RFL3192MF Recombinant Full Length Mouse B-Lymphocyte Antigen Cd20(Ms4A1) Protein, His-Tagged E.coli expression system His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MS4A1 Related Articles
  • MS4A1 Related Research Area

MS4A1 involved in several pathways and played different roles in them. We selected most pathways MS4A1 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with MS4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hematopoietic cell lineageCD2;IL1B;CD38;CD4;Fcer2a;GM-CSF;FCGR1;EPO;CD36

MS4A1 has several biochemical functions, for example, MHC class II protein complex binding, epidermal growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MS4A1 itself. We selected most functions MS4A1 had, and list some proteins which have the same functions with MS4A1. You can find most of the proteins on our site.

Function Related Protein
MHC class II protein complex bindingATP1B1;HSP90AB1;HLA-DMB;HSPA8;HLA-DRA;HSP90AA1;HLA-DOA;HLA-DMA;PKM
epidermal growth factor receptor bindingPLSCR1;ARF4;VAV3;LINGO1B;VAV2;SHC1;SNX1;HBEGFB;EREG
protein bindingTNFSF10;DNAI2;FOXRED2;RMND5A;MTAP;DPEP1;TRIM22;IFT43;ANGPTL4

MS4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MS4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MS4A1.

CCDC155; IGHM; IGHD; CREB3; xthA; tyrS

Ai, J; Advani, A; et al. Current status of antibody therapy in ALL. BRITISH JOURNAL OF HAEMATOLOGY 168:471-480(2015).
Winiarska, M; Bojarczuk, K; et al. Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies. MABS 6:1300-1313(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is the expression of MS4A1 regulated during B-cell development and differentiation? 09/06/2022

 MS4A1 expression is tightly regulated during different stages of B-cell development. It is absent in early B-cell progenitors and gradually increases during maturation. MS4A1 expression is upregulated upon B-cell activation and can be influenced by various cytokines and signaling pathways. This tightly controlled expression pattern ensures proper B-cell development, while aberrant regulation may contribute to B-cell disorders or malignancies.

Can MS4A1 be used as a diagnostic or prognostic marker in B-cell disorders? 08/08/2022

MS4A1 expression levels have been explored as potential diagnostic or prognostic markers for certain B-cell disorders. Quantification of CD20 expression by immunohistochemistry or flow cytometry can aid in the diagnosis and classification of B-cell malignancies. Additionally, low CD20 expression levels have been associated with resistance to CD20-targeted therapies, serving as a prognostic indicator in B-cell lymphomas.

Are there any therapeutic strategies targeting MS4A1 beyond CD20-directed antibodies? 12/19/2020

While CD20-targeted antibodies have revolutionized the treatment of B-cell malignancies, further therapeutic strategies are being explored. These include enhancing CD20 internalization, using antibody-drug conjugates, and developing novel targeted therapies based on the signaling pathways associated with MS4A1. Investigating these approaches may provide alternative treatments and improve outcomes for patients with B-cell disorders.

How does MS4A1 contribute to the regulation of immune tolerance and autoimmunity? 09/30/2019

 MS4A1 helps maintain immune tolerance by preventing the production of autoreactive B cells. It contributes to the elimination of self-reactive B cell clones through mechanisms such as antibody-dependent cellular cytotoxicity and antibody-mediated phagocytosis. MS4A1 dysregulation, however, can lead to the production of autoantibodies and the development of autoimmune diseases. Understanding the fine-tuned regulation of MS4A1's functions is essential for maintaining immune homeostasis and preventing autoimmunity.

What are the interacting partners and downstream signaling pathways of MS4A1? 11/16/2017

MS4A1 interacts with multiple proteins, such as tetraspanins, Src-family kinases, and lipid rafts, which form a complex network involved in B-cell signaling. Upon ligand binding, MS4A1 activates intracellular signaling pathways, including PI3K/Akt and MAPK/ERK, which regulate B-cell survival, proliferation, and differentiation. Understanding these pathways and their crosstalk with MS4A1 can provide insights into B-cell activation and potential therapeutic targets.

What is the structure and function of the MS4A1 protein in immune cells? 11/06/2017

The MS4A1 protein, also known as CD20, is a tetraspanin membrane protein found predominantly in B cells. It plays a crucial role in B-cell development, activation, and antibody production. Structurally, CD20 consists of four transmembrane domains and a large extracellular loop. Functionally, it regulates B-cell signaling by promoting calcium influx upon B-cell receptor activation, modulating cell cycle progression, and facilitating antibody-mediated cytotoxicity.

How does MS4A1 contribute to the pathogenesis of B-cell malignancies? 09/14/2017

MS4A1 dysregulation has been implicated in B-cell malignancies, including non-Hodgkin lymphomas and leukemia. Increased expression or altered signaling of MS4A1 may promote survival and proliferation of malignant B cells. CD20-targeted therapies, such as monoclonal antibodies, have been successfully employed in treating B-cell malignancies, highlighting the significance of MS4A1 as a therapeutic target in these diseases.

Customer Reviews (3)

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Reviews
11/02/2019

    Its strong affinity allows for robust binding to target proteins, thereby enhancing the accuracy of analysis.

    04/05/2017

      Surpassing expectations, it significantly amplifies the results of my research.

      02/07/2017

        The operational guidelines for this reagent are readily comprehensible and accessible, facilitating seamless implementation of experiments, even for individuals lacking prior expertise.

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