MUC1 Protein

MUC1

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MUC1

Official Full Name mucin 1, cell surface associated
Background This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Synonyms MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen;
    • Species :
    • Bovine
    • Cattle
    • Human
    • Mouse
    • Rat
    • Source :
    • Bovine Submaxillary Gland
    • E.coli
    • HEK293
    • HEK293 cells
    • Human Ascites Fluid
    • Human Cell
    • Human cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • DYKDDDDK
    • Fc
    • Fc/Avi
    • His
    • Fc-Avi
    • Fc-His(C-ter)
    • GST
    • S
    • His-Avi
    • human IgG1 Fc
    • LEVLFQ
    • mFc
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MUC1-4770H Active Native Human MUC1 Protein Human Ascites Fluid N/A
    Human MUC1-051H Active Recombinant Human MUC1 protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi
    Human MUC1-376H Active Native Human MUC1 Human Ascites Fluid N/A
    Mouse Muc1-106M Recombinant Mouse Muc1 protein, His/GST-tagged E.coli His/GST
    Human MUC1-27747TH Recombinant Human MUC1, His-tagged E.coli His
    Human MUC1-342H Recombinant Human MUC1, Fc-tagged Human Cell Fc
    Human MUC1-3952H Recombinant Human MUC1, Fc tagged Human Cell Fc
    Human MUC1-448H Recombinant Human MUC1 Protein HEK293 N/A
    Human MUC1-617H Recombinant Human MUC1 Protein, His/GST-tagged E.coli His/GST
    Human MUC1-618H Recombinant Human MUC1 Protein, His-tagged E.coli His
    Human MUC1-745H Recombinant Human MUC1 Protein, His-tagged E.coli His
    Mouse MUC1-10226M Recombinant Mouse MUC1 Protein Mammalian Cell His
    Mouse Muc1-619M Recombinant Mouse Muc1 Protein, His-tagged E.coli His
    Mouse Muc1-621M Recombinant Mouse Muc1 Protein, His/GST-tagged E.coli His/GST
    Rat Muc1-622R Recombinant Rat TRIM21 Protein, His/GST-tagged E.coli His/GST
    Rat Muc1-623R Recombinant Rat TRIM21 Protein, GST/S-tagged E.coli GST/S
    Human MUC1-1980HCL Recombinant Human MUC1 cell lysate Human Cell N/A
    Cattle MUC1-1145C Recombinant Cattle MUC1 Protein, His-tagged E.coli N-His
    Human MUC1-17H Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor® 488 conjugated HEK293 Fc
    Human MUC1-18H Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor® 647 conjugated HEK293 Fc
    Human MUC1-211H Recombinant Human MUC1 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
    Human MUC1-212H Recombinant Human MUC1 Protein, His-tagged Human Cells His
    Human MUC1-213H Recombinant Human MUC1 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
    Human MUC1-244H Recombinant Active Human MUC1 Protein, Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter)
    Human MUC1-261H Recombinant Human MUC1 Protein, mFc-tagged HEK293 mFc
    Human MUC1-342HAF488 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Human MUC1-342HAF555 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Human MUC1-342HAF647 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Human MUC1-342HF Recombinant Human MUC1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Human MUC1-3952HAF488 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Human MUC1-3952HAF555 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Human MUC1-3952HAF647 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Human MUC1-3952HF Recombinant Human MUC1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Human MUC1-448HAF488 Recombinant Human MUC1 Protein, Alexa Fluor 488 conjugated HEK293 LEVLFQ
    Human MUC1-448HAF555 Recombinant Human MUC1 Protein, Alexa Fluor 555 conjugated HEK293 LEVLFQ
    Human MUC1-448HAF647 Recombinant Human MUC1 Protein, Alexa Fluor 647 conjugated HEK293 LEVLFQ
    Human MUC1-448HF Recombinant Human MUC1 Protein, FITC conjugated HEK293 LEVLFQ
    Human MUC1-620H Recombinant Human MUC1(Pro24-Gly167) Protein, C-Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi
    Mouse MUC1-77M Recombinant Mouse MUC1 Protein, His-tagged HEK293 His
    Human MUC1-2061H Recombinant Human MUC1 Protein, Fc/His-tagged HEK293 Fc/His
    Human MUC1-2139H Recombinant Human MUC1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MUC1-342HA Recombinant Human MUC1 protein, Fc-tagged, APC labeled HEK293 Fc
    Human MUC1-342HP Recombinant Human MUC1 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human MUC1-343H Recombinant Human MUC1 Protein, Fc-tagged HEK293 Fc
    Human MUC1-3952HA Recombinant Human MUC1 protein, Fc-tagged, APC labeled HEK293 Fc
    Human MUC1-3952HP Recombinant Human MUC1 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human MUC1-5745H Recombinant Human MUC1 Protein, GST-tagged Wheat Germ GST
    Human MUC1-619H Recombinant Human MUC1 Protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human MUC1-726H Recombinant Human MUC1 protein, Fc-tagged HEK293 human IgG1 Fc
    Bovine MUC1-135B Native Bovine MUC1 Protein Bovine Submaxillary Gland N/A

    MUC1 involved in several pathways and played different roles in them. We selected most pathways MUC1 participated on our site, such as IL-7 Signaling Pathway, Metabolism of proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    IL-7 Signaling Pathway IRF1B; STAM2; MUC1
    Metabolism of proteins A4GNT; ADAMTS4; SCMH1; FBXW9; TRAPPC1; YKT6; F9B; GPR116; CPA3; ASNA1
    O-linked glycosylation GALNT5; B3GNT6; ADAMTS20; ADAMTSL4; ADAMTSL1; SPON2; SPON1; GCNT3; THSD7A; THSD1
    O-linked glycosylation of mucins GALNTL2; B3GNT8; MUC12; MUCL1; MUC5AC; B3GNT6; A4GNT; MUC15; KCNA6; B3GNT2A
    Post-translational protein modification MPDU1B; NAPAB; TRAPPC5; DNAJC24; DPH3; SSPO; MAN1A2; ARSI; PPP6R1; ADAMTS5
    T Cell Receptor Signaling Pathway VAV3; CD3E; CD3D; CD40LG; IL5; PPP3CC; PAK2; RELA; LCP2; TEC; CARD11
    Termination of O-glycan biosynthesis MUC15; MUC20; MUC4; MUCL1; MUC5AC; MUC21; MUC1; MUC12; MUC13

    MUC1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MUC1 itself. We selected most functions MUC1 had, and list some proteins which have the same functions with MUC1. You can find most of the proteins on our site.

    Function Related Protein

    MUC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC1.

    Zhang, Q; Wang, F; et al. Dual-color labeled anti-mucin 1 antibody for imaging of ovarian cancer: A preliminary animal study. ONCOLOGY LETTERS 9:1231-1235(2015).
    Zhan, XX; Zhao, B; et al. Expression of MUC1 and CD176 (Thomsen-Friedenreich antigen) in Papillary Thyroid Carcinomas. ENDOCRINE PATHOLOGY 26:21-26(2015).

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