MUC1

  • Official Full Name

    mucin 1, cell surface associated

  • Overview

    This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
  • Synonyms

    MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen;

  • Native Proteins
  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • Bovine Submaxillary Gland
  • E.coli
  • HEK293
  • HEK293 cells
  • Human Ascites Fluid
  • Human Cell
  • Human cells
  • Human Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Fc
  • hFc
  • His
  • DYKDDDDK
  • Avi
  • Fc|His
  • His(C
  • ter)
  • GST
  • GST|S
  • His (Fc)
  • His|GST
  • human IgG1 Fc
  • LEVLFQ
  • mFc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MUC1-4770H Active Native Human MUC1 Protein Human Ascites Fluid N/A
Human MUC1-051H Active Recombinant Human MUC1 protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi Ser24-Ser380
Human MUC1-376H Active Native Human MUC1 Human Ascites Fluid N/A
Human MUC1-17H Active Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor® 488 conjugated HEK293 Fc
Human MUC1-244H Recombinant Active Human MUC1 Protein, Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Met1-Gly167
Human MUC1-18H Active Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor® 647 conjugated HEK293 Fc
Human MUC1-27747TH Recombinant Human MUC1, His-tagged E.coli His
Human MUC1-618H Recombinant Human MUC1 Protein, His-tagged E.coli His Pro1034~Gln1151
Human MUC1-745H Recombinant Human MUC1 Protein, His-tagged E.coli His
Human MUC1-3952H Recombinant Human MUC1, Fc tagged HEK293 Fc Met 1-Gly 167
Human MUC1-342H Recombinant Human MUC1 protein(Met1-Gly167), hFc-tagged HEK293 C-hFc Met1-Gly167
Human MUC1-617H Recombinant Human MUC1 Protein, His/GST-tagged E.coli His/GST Ser1098~Leu1255
Human MUC1-448H Recombinant Human MUC1 protein(Met 1-Gly 167) HEK293 N/A Met 1-Gly 167
Human MUC1-1980HCL Recombinant Human MUC1 cell lysate Human Cell N/A
Human MUC1-726H Recombinant Human MUC1 protein, Fc-tagged HEK293 human IgG1 Fc Ser33-Gly167
Human MUC1-0037H Recombinant Human MUC1 Protein HEK293 cells
Human MUC1-2139H Recombinant Human MUC1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MUC1-0036H Recombinant Human MUC1 Protein HEK293 cells
Human MUC1-343H Recombinant Human MUC1 Protein, Fc-tagged HEK293 Fc Ser 24 - Ser 380
Human MUC1-0501H Active Recombinant Human MUC1 protein, His-tagged HEK293 His Ser890-Gly1158
Human MUC1-342HA Recombinant Human MUC1 protein, Fc-tagged, APC labeled HEK293 Fc
Human MUC1-4620H Recombinant Human MUC1 Protein (Met1-Gly167), C-His tagged Mammalian cells C-His Met1-Gly167
Human MUC1-212H Recombinant Human MUC1 Protein, His-tagged Human Cells His
Human MUC1-5745H Recombinant Human MUC1 Protein, GST-tagged Wheat Germ GST
Human MUC1-3952HP Recombinant Human MUC1 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human MUC1-4621H Recombinant Human MUC1 Protein (Met1-Pro146), C-His tagged Mammalian cells C-His Met1-Pro146
Human MUC1-342HAF555 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Met1-Gly167, 369
Human MUC1-3952HA Recombinant Human MUC1 protein, Fc-tagged, APC labeled HEK293 Fc
Human MUC1-213H Recombinant Human MUC1 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human MUC1-4622H Recombinant Human MUC1 Protein (Ala927-Gly1158), C-His tagged Mammalian cells C-His Ala927-Gly1158
Human MUC1-448HAF555 Recombinant Human MUC1 Protein, Alexa Fluor 555 conjugated HEK293 LEVLFQ 142
Human MUC1-619H Active Recombinant Human MUC1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ser 890 - Gly 1158
Human MUC1-342HAF488 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Met1-Gly167, 369
Human MUC1-4623H Recombinant Human MUC1 Protein (Thr931-Gly1158), N-His tagged E.coli N-His Thr931-Gly1158
Human MUC1-3952HAF647 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 376
Human MUC1-211H Recombinant Human MUC1 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human MUC1-3952HAF488 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 376
Human MUC1-2661H Recombinant Human MUC1 protein(31-150 aa), C-His-tagged E.coli C-His 31-150 aa
Human MUC1-3952HF Recombinant Human MUC1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 376
Human MUC1-620H Recombinant Human MUC1(Pro24-Gly167) Protein, C-Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi
Human MUC1-1349H Recombinant Human MUC1 Protein (Ser24-Pro146), N-His tagged E.coli N-His Ser24-Pro146
Human MUC1-2662H Recombinant Human MUC1 protein(31-100 aa), C-His-tagged E.coli C-His 31-100 aa
Human MUC1-386H Recombinant Human MUC1 Protein, Fc-tagged HEK293 Fc 1255
Human MUC1-261H Recombinant Human MUC1 Protein, mFc-tagged HEK293 mFc Met1-Gly167
Human MUC1-0496H Recombinant Human MUC1 protein, mFc-tagged HEK293 mFc Ser1098-Gly1158
Human MUC1-2061H Recombinant Human MUC1 Protein, Fc/His-tagged HEK293 Fc/His Met1-Gly167
Human MUC1-0500H Recombinant Human MUC1 protein, Fc-tagged HEK293 Fc Ser116-Gly173
Human MUC1-448HAF488 Recombinant Human MUC1 Protein, Alexa Fluor 488 conjugated HEK293 LEVLFQ 142
Human MUC1-0497H Recombinant Human MUC1 protein, Fc-tagged E.coli Fc Ser116-Gly173
Human MUC1-342HP Recombinant Human MUC1 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human MUC1-0502H Active Recombinant Human MUC1 protein, His-tagged HEK293 His Leu1036-Gly1155
Human MUC1-3952HAF555 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 376
Human MUC1-4625H Recombinant Human MUC1 Protein (Met1-Ser380), C-Fc tagged Mammalian cells C-Fc Met1-Ser380
Human MUC1-342HF Recombinant Human MUC1 Protein, Fc-tagged, FITC conjugated HEK293 Fc Met1-Gly167, 369
Human MUC1-342HAF647 Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Met1-Gly167, 369
Human MUC1-448HAF647 Recombinant Human MUC1 Protein, Alexa Fluor 647 conjugated HEK293 LEVLFQ 142
Human MUC1-448HF Recombinant Human MUC1 Protein, FITC conjugated HEK293 LEVLFQ 142
Mouse MUC1-10226M Recombinant Mouse MUC1 Protein Mammalian Cell His
Mouse Muc1-619M Recombinant Mouse Muc1 Protein, His-tagged E.coli His Ser410~Ala525
Mouse Muc1-621M Recombinant Mouse Muc1 Protein, His/GST-tagged E.coli His/GST Ser474~Leu630
Mouse Muc1-106M Recombinant Mouse Muc1 protein, His/GST-tagged E.coli His/GST Ser410~Ala525
Mouse MUC1-77M Recombinant Mouse MUC1 Protein, His-tagged HEK293 His
Mouse MUC1-5801M Recombinant Mouse MUC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MUC1-5801M-B Recombinant Mouse MUC1 Protein Pre-coupled Magnetic Beads HEK293
Rat Muc1-622R Recombinant Rat TRIM21 Protein, His/GST-tagged E.coli His/GST Ser404~Leu655
Rat Muc1-623R Recombinant Rat TRIM21 Protein, GST/S-tagged E.coli GST/S Met1~Thr350
Bovine MUC1-135B Native Bovine MUC1 Protein Bovine Submaxillary Gland N/A
Cattle MUC1-1145C Recombinant Cattle MUC1 Protein, His-tagged E.coli N-His Asn23-Ala489
Cynomolgus MUC1-0498C Recombinant Cynomolgus MUC1 protein, Fc-tagged HEK293 Fc Leu254-Gly373
Cynomolgus MUC1-0499C Recombinant Cynomolgus MUC1 protein, His-tagged HEK293 His Leu254-Gly373
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MUC1 involved in several pathways and played different roles in them. We selected most pathways MUC1 participated on our site, such as IL-7 Signaling Pathway, Metabolism of proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
IL-7 Signaling PathwaySTAM2;IRF1B;MUC1
Metabolism of proteinsIGFBP4;C19orf10;ADAMTSL5;GRP;PHC1;LDHD;TBCC;ADAMTS18;GALNTL5
O-linked glycosylationADAMTSL3;SSPO;MUC1;SPON1B;MUC4;GALNTL2;B3GNT8;ADAMTSL1;ADAMTS15
O-linked glycosylation of mucinsMUC12;GALNTL2;KCNA6;GALNT13;GALNT6;B3GNT8;MUC13;MUC15;B3GNT2A
Post-translational protein modificationNAPAB;CBX4;SSPO;ALG14;SENP5;SMC5;TRAPPC6B;MUC12;PPP6R1
T Cell Receptor Signaling PathwayPRKCQ;EVLB;CD4;NFATC3;MAP2K2;ZAP70;PIK3R3;PPP3CA;PAK2
Termination of O-glycan biosynthesisMUC4;MUC20;MUC5AC;MUC12;MUC13;MUC21;MUC1;MUCL1;MUC15

MUC1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MUC1 itself. We selected most functions MUC1 had, and list some proteins which have the same functions with MUC1. You can find most of the proteins on our site.

Function Related Protein

MUC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC1.

Research Area

Related articles

Zhang, Q; Wang, F; et al. Dual-color labeled anti-mucin 1 antibody for imaging of ovarian cancer: A preliminary animal study. ONCOLOGY LETTERS 9:1231-1235(2015).
Zhan, XX; Zhao, B; et al. Expression of MUC1 and CD176 (Thomsen-Friedenreich antigen) in Papillary Thyroid Carcinomas. ENDOCRINE PATHOLOGY 26:21-26(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
03/11/2022

    It is suitable for crystallography research and has good crystallinity.

    02/04/2022

      Target immune responses can be successfully induced.

      06/04/2019

        Enzymatic experiments showed that the catalytic efficiency was high

        Q&As (6)

        Ask a question
        What are the structural characteristics of the MUC1 protein? 11/12/2019

        The MUC1 protein consists of a short extracellular region, a transmembrane region, and a long intracellular region. The extracellular region is rich in sugar chains, which make the MUC1 protein adherent.

        What is the role of the MUC1 protein in cancer? 10/16/2019

        In cancer, the expression of the MUC1 protein usually increases abnormally and changes in glycosylation occur. This can affect cell adhesion, proliferation, and invasion, promoting the spread and metastasis of cancer cells.

        Is the MUC1 protein involved in the immune system? 09/02/2019

        Yes, the MUC1 protein is closely related to the immune system. In some cases, abnormal expression of the MUC1 protein may interfere with the function of immune cells, thereby reducing the immune response.

        In which diseases is MUC1 involved in the diagnosis and treatment? 08/17/2019

        MUC1 protein is overexpressed in many types of cancer, including breast, stomach, ovarian, and others. Therefore, the MUC1 protein can be a potential target for cancer diagnosis and treatment.

        What are the main physiological functions of MUC1 protein? 06/22/2019

        The MUC1 protein mainly plays the role of protecting and lubricating the mucosal surface. It prevents bacteria and other pathogens from entering our body, while also helping to maintain cell-to-cell adhesion.

        Is the MUC1 protein associated with other diseases? 06/01/2019

        MUC1 protein may be associated with a number of other diseases, such as lung infections and inflammatory bowel disease. However, the research related to cancer is more extensive and in-depth.

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