|Official Full Name||mucin 1, cell surface associated|
|Background||This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]|
|Synonyms||MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MUC1 involved in several pathways and played different roles in them. We selected most pathways MUC1 participated on our site, such as IL-7 Signaling Pathway, Metabolism of proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|IL-7 Signaling Pathway||IRF1B; STAM2; MUC1|
|Metabolism of proteins||A4GNT; ADAMTS4; SCMH1; FBXW9; TRAPPC1; YKT6; F9B; GPR116; CPA3; ASNA1|
|O-linked glycosylation||GALNT5; B3GNT6; ADAMTS20; ADAMTSL4; ADAMTSL1; SPON2; SPON1; GCNT3; THSD7A; THSD1|
|O-linked glycosylation of mucins||GALNTL2; B3GNT8; MUC12; MUCL1; MUC5AC; B3GNT6; A4GNT; MUC15; KCNA6; B3GNT2A|
|Post-translational protein modification||MPDU1B; NAPAB; TRAPPC5; DNAJC24; DPH3; SSPO; MAN1A2; ARSI; PPP6R1; ADAMTS5|
|T Cell Receptor Signaling Pathway||VAV3; CD3E; CD3D; CD40LG; IL5; PPP3CC; PAK2; RELA; LCP2; TEC; CARD11|
|Termination of O-glycan biosynthesis||MUC15; MUC20; MUC4; MUCL1; MUC5AC; MUC21; MUC1; MUC12; MUC13|
MUC1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MUC1 itself. We selected most functions MUC1 had, and list some proteins which have the same functions with MUC1. You can find most of the proteins on our site.
MUC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC1.