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Active Native Human MUC1

Cat.No. : MUC1-376H
Product Overview : Human MUC1 was purified from Human Ascites Fluid
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  • Gene Information
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Description : Cancer Antigen 15-3 (CA 15-3) is used as a tumor marker to monitor a patients response to breast cancer treatment and to watch for breast cancer recurrence.
Source : Human Ascites Fluid
Species : Human
Form : Liquid in phosphate buffered saline, pH 7.4, with 0.05% sodium azide.
Bio-activity : > 5,000 IU/mL (ELISA)
Purity : Control Grade
Applications : Diagnostic Controls, Calibrators & Standards; Immunoassays; Clinical Chemistry; Testing/Assay Validation; Life Science; Manufacturing; Tumor Markers
Storage : Store at -20°C
Tag : Non
Gene Name : MUC1 mucin 1, cell surface associated [ Homo sapiens ]
Official Symbol : MUC1
Synonyms : EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; DF3 antigen; H23 antigen; Medullary cystic kidney disease, autosomal dominant; breast carcinoma-associated antigen DF3; cancer antigen 15-3; carcinoma-associated mucin; episialin; krebs von den Lungen-6; mucin 1, transmembrane; peanut-reactive urinary mucin; polymorphic epithelial mucin; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen
Gene ID : 4582
mRNA Refseq : NM_001018016
Protein Refseq : NP_001018016
MIM : 158340
UniProt ID : P15941
Chromosome Location : 1q21
Pathway : IL-7 Signaling Pathway, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; O-linked glycosylation, organism-specific biosystem
Function : p53 binding; protein binding; transcription cofactor activity

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
03/11/2022

    It is suitable for crystallography research and has good crystallinity.

    02/04/2022

      Target immune responses can be successfully induced.

      06/04/2019

        Enzymatic experiments showed that the catalytic efficiency was high

        Q&As (6)

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        What are the structural characteristics of the MUC1 protein? 11/12/2019

        The MUC1 protein consists of a short extracellular region, a transmembrane region, and a long intracellular region. The extracellular region is rich in sugar chains, which make the MUC1 protein adherent.

        What is the role of the MUC1 protein in cancer? 10/16/2019

        In cancer, the expression of the MUC1 protein usually increases abnormally and changes in glycosylation occur. This can affect cell adhesion, proliferation, and invasion, promoting the spread and metastasis of cancer cells.

        Is the MUC1 protein involved in the immune system? 09/02/2019

        Yes, the MUC1 protein is closely related to the immune system. In some cases, abnormal expression of the MUC1 protein may interfere with the function of immune cells, thereby reducing the immune response.

        In which diseases is MUC1 involved in the diagnosis and treatment? 08/17/2019

        MUC1 protein is overexpressed in many types of cancer, including breast, stomach, ovarian, and others. Therefore, the MUC1 protein can be a potential target for cancer diagnosis and treatment.

        What are the main physiological functions of MUC1 protein? 06/22/2019

        The MUC1 protein mainly plays the role of protecting and lubricating the mucosal surface. It prevents bacteria and other pathogens from entering our body, while also helping to maintain cell-to-cell adhesion.

        Is the MUC1 protein associated with other diseases? 06/01/2019

        MUC1 protein may be associated with a number of other diseases, such as lung infections and inflammatory bowel disease. However, the research related to cancer is more extensive and in-depth.

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