Recombinant Mouse MUC1 Protein, His-tagged

Cat.No. : MUC1-77M
Product Overview : Recombinant Mouse MUC1 Protein, fused to His-tag, was expressed in HEK293.
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Description : Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and regulation of transcription, DNA-templated. Located in apical plasma membrane and cell surface. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including allergic rhinitis; biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated).
Source : HEK293
Species : Mouse
Tag : His
Form : Lyophilized from a 0.2μm filtered solution of PBS and 5% mannitol, 5% trehalose.
Molecular Mass : 19.3 kDa
AA Sequence : HHHHHHTSSVLGSATSLVYNTSAIA TTPVSNGTQPSVPSQYPVSPTMATT SSHSTIASSSYYSTVPFSTFSSNSS PQLSVGVSFFFLSFYIQNHPFNSSL EDPSSNYYQELKRNISGLFLQIFNG DFLGISSIKFRSGSVVVESTVVFRE GTFSASDVKSQLIQHKKEADDYNLT IS
Purity : >90%
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
SDS-PAGE: Reducing 12% SDS-PAGE and WB analysis profile of purified MUC1.
Gene Name : Muc1 mucin 1, transmembrane [ Mus musculus (house mouse) ]
Official Symbol : MUC1
Synonyms : EMA; CD227; Muc-1
Gene ID : 17829
mRNA Refseq : NM_013605
Protein Refseq : NP_038633
UniProt ID : Q02496

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the structural characteristics of the MUC1 protein? 11/12/2019

The MUC1 protein consists of a short extracellular region, a transmembrane region, and a long intracellular region. The extracellular region is rich in sugar chains, which make the MUC1 protein adherent.

What is the role of the MUC1 protein in cancer? 10/16/2019

In cancer, the expression of the MUC1 protein usually increases abnormally and changes in glycosylation occur. This can affect cell adhesion, proliferation, and invasion, promoting the spread and metastasis of cancer cells.

Is the MUC1 protein involved in the immune system? 09/02/2019

Yes, the MUC1 protein is closely related to the immune system. In some cases, abnormal expression of the MUC1 protein may interfere with the function of immune cells, thereby reducing the immune response.

In which diseases is MUC1 involved in the diagnosis and treatment? 08/17/2019

MUC1 protein is overexpressed in many types of cancer, including breast, stomach, ovarian, and others. Therefore, the MUC1 protein can be a potential target for cancer diagnosis and treatment.

What are the main physiological functions of MUC1 protein? 06/22/2019

The MUC1 protein mainly plays the role of protecting and lubricating the mucosal surface. It prevents bacteria and other pathogens from entering our body, while also helping to maintain cell-to-cell adhesion.

Is the MUC1 protein associated with other diseases? 06/01/2019

MUC1 protein may be associated with a number of other diseases, such as lung infections and inflammatory bowel disease. However, the research related to cancer is more extensive and in-depth.

Customer Reviews (3)

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Reviews
03/11/2022

    It is suitable for crystallography research and has good crystallinity.

    02/04/2022

      Target immune responses can be successfully induced.

      06/04/2019

        Enzymatic experiments showed that the catalytic efficiency was high

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