Recombinant Mouse MUC1 Protein, His-tagged
Cat.No. : | MUC1-77M |
Product Overview : | Recombinant Mouse MUC1 Protein, fused to His-tag, was expressed in HEK293. |
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Description : | Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and regulation of transcription, DNA-templated. Located in apical plasma membrane and cell surface. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including allergic rhinitis; biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated). |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Form : | Lyophilized from a 0.2μm filtered solution of PBS and 5% mannitol, 5% trehalose. |
Molecular Mass : | 19.3 kDa |
AA Sequence : | HHHHHHTSSVLGSATSLVYNTSAIA TTPVSNGTQPSVPSQYPVSPTMATT SSHSTIASSSYYSTVPFSTFSSNSS PQLSVGVSFFFLSFYIQNHPFNSSL EDPSSNYYQELKRNISGLFLQIFNG DFLGISSIKFRSGSVVVESTVVFRE GTFSASDVKSQLIQHKKEADDYNLT IS |
Purity : | >90% |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | Muc1 mucin 1, transmembrane [ Mus musculus (house mouse) ] |
Official Symbol : | MUC1 |
Synonyms : | EMA; CD227; Muc-1 |
Gene ID : | 17829 |
mRNA Refseq : | NM_013605 |
Protein Refseq : | NP_038633 |
UniProt ID : | Q02496 |
Products Types
◆ Recombinant Protein | ||
MUC1-5745H | Recombinant Human MUC1 Protein, GST-tagged | +Inquiry |
MUC1-244H | Recombinant Active Human MUC1 Protein, Fc-His-tagged(C-ter) | +Inquiry |
MUC1-7865H | Recombinant Human MUC1 protein, His-tagged | +Inquiry |
MUC1-17H | Active Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor® 488 conjugated | +Inquiry |
MUC1-2661H | Recombinant Human MUC1 protein(31-150 aa), C-His-tagged | +Inquiry |
◆ Native Protein | ||
MUC1-135B | Native Bovine MUC1 Protein | +Inquiry |
MUC1-4770H | Active Native Human MUC1 Protein | +Inquiry |
MUC1-376H | Active Native Human MUC1 | +Inquiry |
◆ Lysates | ||
MUC1-1980HCL | Recombinant Human MUC1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIt is suitable for crystallography research and has good crystallinity.
Target immune responses can be successfully induced.
Enzymatic experiments showed that the catalytic efficiency was high
Q&As (6)
Ask a questionThe MUC1 protein consists of a short extracellular region, a transmembrane region, and a long intracellular region. The extracellular region is rich in sugar chains, which make the MUC1 protein adherent.
In cancer, the expression of the MUC1 protein usually increases abnormally and changes in glycosylation occur. This can affect cell adhesion, proliferation, and invasion, promoting the spread and metastasis of cancer cells.
Yes, the MUC1 protein is closely related to the immune system. In some cases, abnormal expression of the MUC1 protein may interfere with the function of immune cells, thereby reducing the immune response.
MUC1 protein is overexpressed in many types of cancer, including breast, stomach, ovarian, and others. Therefore, the MUC1 protein can be a potential target for cancer diagnosis and treatment.
The MUC1 protein mainly plays the role of protecting and lubricating the mucosal surface. It prevents bacteria and other pathogens from entering our body, while also helping to maintain cell-to-cell adhesion.
MUC1 protein may be associated with a number of other diseases, such as lung infections and inflammatory bowel disease. However, the research related to cancer is more extensive and in-depth.
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