Active Recombinant Human MUC1 protein, His-Avi-tagged, Biotinylated
Cat.No. : | MUC1-619H |
Product Overview : | Biotinylated Recombinant Human MUC1 protein(Ser 890 - Gly 1158), fused with His and Avi tag, was expressed in HEK293. |
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Source : | HEK293 |
Species : | Human |
Tag : | His&Avi |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Bio-activity : | 2e5 of Anti-Mucin-1 CAR-293 cells were stained with 100 μL of 0.1 μg/mL of Biotinylated Human Mucin-1, His,Avitag and negative control protein respectively, washed and then followed by PE-SA and analyzed with FACS. |
Molecular Mass : | This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The mature form of Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved partial α and partial β chain. Each partial α and partial β chain has a calculated MW of 21.3 kDa (partial α chain) and 10.2 kDa (partial β chain). The protein migrates as 45-70 kDa (partial α chain) and 7 kDa and 14-15 kDa (partial β chain) under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein Length : | Ser 890 - Gly 1158 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Storage : | For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | MUC1 mucin 1, cell surface associated [ Homo sapiens ] |
Official Symbol : | MUC1 |
Synonyms : | MUC1; mucin 1, cell surface associated; mucin 1, transmembrane , PUM; mucin-1; CD227; PEM; episialin; DF3 antigen; H23 antigen; krebs von den Lungen-6; mucin 1, transmembrane; tumor-associated mucin; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; EMA; PUM; KL-6; MAM6; PEMT; H23AG; MUC-1; MUC-1/X; MUC1/ZD; MUC-1/SEC; |
Gene ID : | 4582 |
mRNA Refseq : | NM_001018016 |
Protein Refseq : | NP_001018016 |
MIM : | 158340 |
UniProt ID : | P15941 |
Products Types
◆ Recombinant Protein | ||
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MUC1-1535H | Recombinant Human MUC1 protein, hFc-tagged | +Inquiry |
MUC1-386H | Recombinant Human MUC1 Protein, Fc-tagged | +Inquiry |
MUC1-7865H | Recombinant Human MUC1 protein, His-tagged | +Inquiry |
MUC1-342H | Recombinant Human MUC1 protein(Met1-Gly167), hFc-tagged | +Inquiry |
◆ Native Protein | ||
MUC1-135B | Native Bovine MUC1 Protein | +Inquiry |
MUC1-376H | Active Native Human MUC1 | +Inquiry |
MUC1-4770H | Active Native Human MUC1 Protein | +Inquiry |
◆ Lysates | ||
MUC1-1980HCL | Recombinant Human MUC1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIt is suitable for crystallography research and has good crystallinity.
Target immune responses can be successfully induced.
Enzymatic experiments showed that the catalytic efficiency was high
Q&As (6)
Ask a questionThe MUC1 protein consists of a short extracellular region, a transmembrane region, and a long intracellular region. The extracellular region is rich in sugar chains, which make the MUC1 protein adherent.
In cancer, the expression of the MUC1 protein usually increases abnormally and changes in glycosylation occur. This can affect cell adhesion, proliferation, and invasion, promoting the spread and metastasis of cancer cells.
Yes, the MUC1 protein is closely related to the immune system. In some cases, abnormal expression of the MUC1 protein may interfere with the function of immune cells, thereby reducing the immune response.
MUC1 protein is overexpressed in many types of cancer, including breast, stomach, ovarian, and others. Therefore, the MUC1 protein can be a potential target for cancer diagnosis and treatment.
The MUC1 protein mainly plays the role of protecting and lubricating the mucosal surface. It prevents bacteria and other pathogens from entering our body, while also helping to maintain cell-to-cell adhesion.
MUC1 protein may be associated with a number of other diseases, such as lung infections and inflammatory bowel disease. However, the research related to cancer is more extensive and in-depth.
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