Native Bovine MUC1 Protein


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Native Bovine MUC1 Protein

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Cat.No. : MUC1-135B
Product Overview : Native Bovine MUC1 was purified from Bovine Submaxillary Gland.
Description : Mucins are glycoproteins abundant with O-linked oligosaccharides secreted by epithelial mucous membranes. Their protective function is due to their high viscosity. Bovine submaxillary mucin has a molecular weight of 4 - 40 X 105 daltons. The molecule consists of major and minor components with a protein moiety (36.6% of the molecule) and a carbohydrate moiety (56.7% of the molecule). Mucins are the glycoproteins in epithelial mucous secretions; their protective function is due to their high viscosity. Svennerholm (1963) describes the preparation of sialic acids from mucin. Tettamanti and Pigman (1968) separated BSM into major and minor components and determined the amino acids of the protein moiety (36.6% of the molecule). Besides sialic acid and N-acetyl-galactosamine they reported small amounts of fructose and galactose. Bettelheim et al. (1972) report the carbohydrate content to be 56.7% and the molecular shape to be that of a stiff rod. Downs and Pigman (1969) and Pigman et al. (1973) suggest the possibility of a repeating glycopeptide structure.
Source : Bovine Submaxillary Gland
Species : Bovine
Form : A dry powder prepared by the method of Nisizawa, K., and Pigman, W.: Arch. Oral. Biol., 1, 161 (1959). Suitable as a substrate for neuraminidase.
Molecular Mass : 400,000 (Downs and Pigman 1969). 4,000,000 by light-scattering (Bettelheim et al. 1962).
Notes : Protect from moisture.
Storage : Stable indefinately at 2 - 8 centigrade. Protect from moisture.
Gene Name : MUC1 mucin 1, cell surface associated [ Bos taurus ]
Official Symbol : MUC1
Synonyms : mucin; MUC-1; mucin 1, transmembrane
Gene ID : 281333
mRNA Refseq : NM_174115
Protein Refseq : NP_776540
UniProt ID : Q8WML4

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