Recombinant Human MUC1 protein(31-100 aa), C-His-tagged

• Cat.No.: MUC1-2662H
• Product Overview: Recombinant Human MUC1 protein(P15941)(31-100 aa), fused with C-terminal His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Protein length: 31-100 aa
• Form: 0.15 M Phosphate buffered saline
• AASequence: PGGEKETSATQRSSVPSSTEKNAVS MTSSVLSSHSPGSGSSTTQGQDVTL APATEPASGSAATWGQDVTS
• Storage: Shipped on dry ice. Avoid repeated freeze-thaw cycles. Upon receipt, 2 days when stored at 2 to 8 °C after thawing.
  Up to 12 months when aliquoted and stored at -20 to -80°C.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: MUC1 mucin 1, cell surface associated [ Homo sapiens ]
• Official Symbol: MUC1
• Synonyms: MUC1; mucin 1, cell surface associated; mucin 1, transmembrane , PUM; mucin-1; CD227; PEM; episialin; DF3 antigen; H23 antigen; krebs von den Lungen-6; mucin 1, transmembrane; tumor-associated mucin; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; EMA; PUM; KL-6; MAM6; PEMT; H23AG; MUC-1; MUC-1/X; MUC1/ZD; MUC-1/SEC
• Gene ID: 4582
• mRNA Refseq: NM_001018016
• Protein Refseq: NP_001018016
• MIM: 158340
• UniProt ID: P15941

Reviews

03/11/2022

It is suitable for crystallography research and has good crystallinity.

02/04/2022

Target immune responses can be successfully induced.

06/04/2019

Enzymatic experiments showed that the catalytic efficiency was high

Q&As

What are the structural characteristics of the MUC1 protein?

The MUC1 protein consists of a short extracellular region, a transmembrane region, and a long intracellular region. The extracellular region is rich in sugar chains, which make the MUC1 protein adherent.

What is the role of the MUC1 protein in cancer?

In cancer, the expression of the MUC1 protein usually increases abnormally and changes in glycosylation occur. This can affect cell adhesion, proliferation, and invasion, promoting the spread and metastasis of cancer cells.

Is the MUC1 protein involved in the immune system?

Yes, the MUC1 protein is closely related to the immune system. In some cases, abnormal expression of the MUC1 protein may interfere with the function of immune cells, thereby reducing the immune response.

In which diseases is MUC1 involved in the diagnosis and treatment?

MUC1 protein is overexpressed in many types of cancer, including breast, stomach, ovarian, and others. Therefore, the MUC1 protein can be a potential target for cancer diagnosis and treatment.

What are the main physiological functions of MUC1 protein?

The MUC1 protein mainly plays the role of protecting and lubricating the mucosal surface. It prevents bacteria and other pathogens from entering our body, while also helping to maintain cell-to-cell adhesion.

Is the MUC1 protein associated with other diseases?

MUC1 protein may be associated with a number of other diseases, such as lung infections and inflammatory bowel disease. However, the research related to cancer is more extensive and in-depth.