Recombinant Human MUC1, His-tagged
Cat.No. : | MUC1-27747TH |
Product Overview : | Recombinant Human MUC1(1095 to 1140) fussed with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. Joyce Taylor-Papadimitriou identified and characterised the antigen during her work with breast and ovarian tumors. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilised |
Molecular Mass : | 14 kDa including tags(His tag is 4kDa, Fusion protein size is 10 kDa) |
AA Sequence : | RPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVS |
Applications : | Western blot; ELISA; SDS-PAGE |
Stability : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.Preservative: NoneConstituents: PBS |
Storage : | Store at -20°C |
Reconstitution : | Redissolve the powder with 1ml sterile water. |
Gene Name : | MUC1 mucin 1, cell surface associated [ Homo sapiens ] |
Official Symbol : | MUC1 |
Synonyms : | EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; DF3 antigen; H23 antigen; Medullary cystic kidney disease, autosomal dominant; breast carcinoma-associated antigen DF3; cancer antigen 15-3; carcinoma-associated mucin; episialin; krebs von den Lungen-6; mucin 1, transmembrane; peanut-reactive urinary mucin; polymorphic epithelial mucin; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen |
Gene ID : | 4582 |
mRNA Refseq : | NM_001018016 |
Protein Refseq : | NP_001018016 |
MIM : | 158340 |
UniProt ID : | P15941 |
Chromosome Location : | 1q21 |
Pathway : | IL-7 Signaling Pathway, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; O-linked glycosylation, organism-specific biosystem |
Function : | p53 binding; protein binding; transcription cofactor activity |
Products Types
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◆ Native Protein | ||
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MUC1-376H | Active Native Human MUC1 | +Inquiry |
MUC1-4770H | Active Native Human MUC1 Protein | +Inquiry |
◆ Lysates | ||
MUC1-1980HCL | Recombinant Human MUC1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe MUC1 protein consists of a short extracellular region, a transmembrane region, and a long intracellular region. The extracellular region is rich in sugar chains, which make the MUC1 protein adherent.
In cancer, the expression of the MUC1 protein usually increases abnormally and changes in glycosylation occur. This can affect cell adhesion, proliferation, and invasion, promoting the spread and metastasis of cancer cells.
Yes, the MUC1 protein is closely related to the immune system. In some cases, abnormal expression of the MUC1 protein may interfere with the function of immune cells, thereby reducing the immune response.
MUC1 protein is overexpressed in many types of cancer, including breast, stomach, ovarian, and others. Therefore, the MUC1 protein can be a potential target for cancer diagnosis and treatment.
The MUC1 protein mainly plays the role of protecting and lubricating the mucosal surface. It prevents bacteria and other pathogens from entering our body, while also helping to maintain cell-to-cell adhesion.
MUC1 protein may be associated with a number of other diseases, such as lung infections and inflammatory bowel disease. However, the research related to cancer is more extensive and in-depth.
Customer Reviews (3)
Write a reviewIt is suitable for crystallography research and has good crystallinity.
Target immune responses can be successfully induced.
Enzymatic experiments showed that the catalytic efficiency was high
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