Active Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor® 647 conjugated

Cat.No. : MUC1-18H
Product Overview : Recombinant human Alexa Fluor® 647 conjugated MUC-1 (Ser24-Ser380) protein with human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in human embryonic kidney cell.
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Description : This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Fc
Form : Labeled with Alexa Fluor® 647
Excitation Wavelength: 650 nm
Emission Wavelength: 668 nm
Bio-activity : Measured by flow cytometry for its ability to bind anti-Human MUC-1 Monoclonal Antibody conjugated beads. The concentration of Recombinant human MUC-1 Chimera Alexa Fluor® 647 that produces 50% of the binding response is 0.5-10 ng/mL
Molecular Mass : 60 kDa
N-terminal Sequence Analysis : Ser24
Endotoxin : <1.0 EU/μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Protect from light. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
6 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after opening.
3 months, -20 to -70 centigrade under sterile conditions after opening.
Storage Buffer : Supplied as a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping : The product is shipped with dry ice or equivalent.
SDS-PAGE: Streptavidin coated beads conjugated to biotinylated anti-Human MUC-1 Monoclonal Antibody were stained with the indicated concentrations of Recombinant Human MUC-1 Fc Chimera Alexa Fluor® 647.
Gene Name : MUC1 mucin 1, cell surface associated [ Homo sapiens (human) ]
Official Symbol : MUC1
Synonyms : MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADTKD2; Ca15-3; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; H23 antigen; breast carcinoma-associated antigen DF3; cancer antigen 15-3; carcinoma-associated mucin; episialin; krebs von den Lungen-6; mucin 1, transmembrane; peanut-reactive urinary mucin; polymorphic epithelial mucin; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen
Gene ID : 4582
mRNA Refseq : NM_002456
Protein Refseq : NP_002447
MIM : 158340
UniProt ID : P15941

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What are the structural characteristics of the MUC1 protein? 11/12/2019

The MUC1 protein consists of a short extracellular region, a transmembrane region, and a long intracellular region. The extracellular region is rich in sugar chains, which make the MUC1 protein adherent.

What is the role of the MUC1 protein in cancer? 10/16/2019

In cancer, the expression of the MUC1 protein usually increases abnormally and changes in glycosylation occur. This can affect cell adhesion, proliferation, and invasion, promoting the spread and metastasis of cancer cells.

Is the MUC1 protein involved in the immune system? 09/02/2019

Yes, the MUC1 protein is closely related to the immune system. In some cases, abnormal expression of the MUC1 protein may interfere with the function of immune cells, thereby reducing the immune response.

In which diseases is MUC1 involved in the diagnosis and treatment? 08/17/2019

MUC1 protein is overexpressed in many types of cancer, including breast, stomach, ovarian, and others. Therefore, the MUC1 protein can be a potential target for cancer diagnosis and treatment.

What are the main physiological functions of MUC1 protein? 06/22/2019

The MUC1 protein mainly plays the role of protecting and lubricating the mucosal surface. It prevents bacteria and other pathogens from entering our body, while also helping to maintain cell-to-cell adhesion.

Is the MUC1 protein associated with other diseases? 06/01/2019

MUC1 protein may be associated with a number of other diseases, such as lung infections and inflammatory bowel disease. However, the research related to cancer is more extensive and in-depth.

Customer Reviews (3)

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Reviews
03/11/2022

    It is suitable for crystallography research and has good crystallinity.

    02/04/2022

      Target immune responses can be successfully induced.

      06/04/2019

        Enzymatic experiments showed that the catalytic efficiency was high

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