Recombinant Human MUC1 Protein, Fc-tagged, Alexa Fluor 647 conjugated
Cat.No. : | MUC1-3952HAF647 |
Product Overview : | Alexa Fluor 647 conjugated recombinant human MUC1 (NP_001018016.1) isoform 2 extracellular domain (Met 1-Gly 167), fused with the Fc region of human IgG1 at the C-terminus, was produced in Human Cell. |
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Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized |
Molecular Mass : | The recombinant human MUC1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 376 amino acids after removal the signal peptide and has a predicted molecular mass of 42 kDa. As a result of glycosylation, rh MUC1/Fc monomer migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions. |
Protein length : | 376 |
Endotoxin : | < 1.0 EU/ μg of the protein as determined by the LAL method. |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 647 via amines Excitation = 650 nm Emission = 668 nm |
Stability : | Samples are stable for up to 12 months from date of receipt at -70 centigrade. |
Storage : | Store it under sterile conditions at -20 to -70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4 |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | MUC1 mucin 1, cell surface associated [ Homo sapiens ] |
Official Symbol : | MUC1 |
Gene ID : | 4582 |
mRNA Refseq : | NM_001018016 |
Protein Refseq : | NP_001018016 |
MIM : | 158340 |
UniProt ID : | P15941 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe MUC1 protein consists of a short extracellular region, a transmembrane region, and a long intracellular region. The extracellular region is rich in sugar chains, which make the MUC1 protein adherent.
In cancer, the expression of the MUC1 protein usually increases abnormally and changes in glycosylation occur. This can affect cell adhesion, proliferation, and invasion, promoting the spread and metastasis of cancer cells.
Yes, the MUC1 protein is closely related to the immune system. In some cases, abnormal expression of the MUC1 protein may interfere with the function of immune cells, thereby reducing the immune response.
MUC1 protein is overexpressed in many types of cancer, including breast, stomach, ovarian, and others. Therefore, the MUC1 protein can be a potential target for cancer diagnosis and treatment.
The MUC1 protein mainly plays the role of protecting and lubricating the mucosal surface. It prevents bacteria and other pathogens from entering our body, while also helping to maintain cell-to-cell adhesion.
MUC1 protein may be associated with a number of other diseases, such as lung infections and inflammatory bowel disease. However, the research related to cancer is more extensive and in-depth.
Customer Reviews (3)
Write a reviewIt is suitable for crystallography research and has good crystallinity.
Target immune responses can be successfully induced.
Enzymatic experiments showed that the catalytic efficiency was high
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