Recombinant Human STAT1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : STAT1-5249H
Product Overview : STAT1 MS Standard C13 and N15-labeled recombinant protein (NP_644671) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 83 kDa
AA Sequence : MSQWYELQQLDSKFLEQVHQLYDDS FPMEIRQYLAQWLEKQDWEHAANDV SFATIRFHDLLSQLDDQYSRFSLEN NFLLQHNIRKSKRNLQDNFQEDPIQ MSMIIYSCLKEERKILENAQRFNQA QSGNIQSTVMLDKQKELDSKVRNVK DKVMCIEHEIKSLEDLQDEYDFKCK TLQNREHETNGVAKSDQKQEQLLLK KMYLMLDNKRKEVVHKIIELLNVTE LTQNALINDELVEWKRRQQSACIGG PPNACLDQLQNWFTIVAESLQQVRQ QLKKLEELEQKYTYEHDPITKNKQV LWDRTFSLFQQLIQSSFVVERQPCM PTHPQRPLVLKTGVQFTVKLRLLVK LQELNYNLKVKVLFDKDVNERNTVK GFRKFNILGTHTKVMNMEESTNGSL AAEFRHLQLKEQKNAGTRTNEGPLI VTEELHSLSFETQLCQPGLVIDLET TSLPVVVISNVSQLPSGWASILWYN MLVAEPRNLSFFLTPPCARWAQLSE VLSWQFSSVTKRGLNVDQLNMLGEK LLGPNASPDGLIPWTRFCKENINDK NFPFWLWIESILELIKKHLLPLWND GCIMGFISKERERALLKDQQPGTFL LRFSESSREGAITFTWVERSQNGGE PDFHAVEPYTKKELSAVTFPDIIRN YKVMAAENIPENPLKYLYPNIDKDH AFGKYYSRPKEAPEPMELDGPKGTG YIKTELISVSEVTRTRPLEQKLISE EDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE:
Gene Name : STAT1 signal transducer and activator of transcription 1 [ Homo sapiens (human) ]
Official Symbol : STAT1
Synonyms : STAT1; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1-alpha/beta; ISGF 3; STAT91; transcription factor ISGF 3 components p91/p84; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1; CANDF7; ISGF-3; DKFZp686B04100;
Gene ID : 6772
mRNA Refseq : NM_139266
Protein Refseq : NP_644671
MIM : 600555
UniProt ID : P42224

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the function of the STAT1 protein? 12/23/2019

STAT1 is a signal transduction and transcriptional activator involved in regulating a variety of biological processes such as cell growth, differentiation, apoptosis, and immune response.

Are mutations in genes associated with the STAT1 protein related to human disease? 09/21/2019

Mutations in the STAT1 gene have been found to be associated with a variety of diseases, including autoimmune diseases, primary immunodeficiency diseases, and malignant tumors.

What is the signaling pathway of STAT1 protein in immune cells? 09/01/2019

The STAT1 protein is primarily activated by the JAK-STAT signaling pathway. When activated by the receptor, JAK kinase phosphorylates the STAT1 protein, allowing it to form dimers and enter the nucleus to regulate transcription of related genes.

In which diseases does the STAT1 protein play an important role in the development of diseases? 07/16/2019

The STAT1 protein plays an important role in many diseases, including tumors, immune-related diseases (such as immunodeficiency diseases, autoimmune diseases), infectious diseases (such as viral infections), etc.

Are there activators or inhibitors of the STAT1 protein? 06/19/2019

Some activators or inhibitors of the STAT1 protein have been identified. These compounds can be used to study the function of the STAT1 protein and the development of disease treatments.

Is the STAT1 protein involved in the immune response to viral infection? 02/24/2019

The STAT1 protein plays an important role in viral infection. It mediates interferon signaling, promotes antiviral immune responses, and inhibits viral replication and transmission.

Customer Reviews (3)

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04/22/2020

    It is well suited for our laboratory to induce specific immune responses.

    11/26/2019

      It has great application potential and performs well in all aspects.

      04/16/2019

        This protein has high yield and high purity, which greatly improves our production efficiency.

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