Recombinant Mouse Stat1 protein, His & T7-tagged

• Cat.No.: Stat1-1733M
• Product Overview: Recombinant Mouse Stat1 aa. (Ser432~Tyr680 (Accession # P42225)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His&T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 32.2kDa.
• Protein length: Ser432~Tyr680 (Accession # P42225)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 5.9.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage Buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Stat1 signal transducer and activator of transcription 1 [ Mus musculus (house mouse) ]
• Official Symbol: Stat1
• Synonyms: Dlg5; discs, large homolog 5 (Drosophila); T25557; mKIAA0583; 4933429D20Rik; disks large homolog 5
• Gene ID: 20846
• mRNA Refseq: NM_001205313.1
• Protein Refseq: NP_001192242.1
• UniProt ID: P42225

Reviews

04/22/2020

It is well suited for our laboratory to induce specific immune responses.

11/26/2019

It has great application potential and performs well in all aspects.

04/16/2019

This protein has high yield and high purity, which greatly improves our production efficiency.

Q&As

What is the function of the STAT1 protein?

STAT1 is a signal transduction and transcriptional activator involved in regulating a variety of biological processes such as cell growth, differentiation, apoptosis, and immune response.

Are mutations in genes associated with the STAT1 protein related to human disease?

Mutations in the STAT1 gene have been found to be associated with a variety of diseases, including autoimmune diseases, primary immunodeficiency diseases, and malignant tumors.

What is the signaling pathway of STAT1 protein in immune cells?

The STAT1 protein is primarily activated by the JAK-STAT signaling pathway. When activated by the receptor, JAK kinase phosphorylates the STAT1 protein, allowing it to form dimers and enter the nucleus to regulate transcription of related genes.

In which diseases does the STAT1 protein play an important role in the development of diseases?

The STAT1 protein plays an important role in many diseases, including tumors, immune-related diseases (such as immunodeficiency diseases, autoimmune diseases), infectious diseases (such as viral infections), etc.

Are there activators or inhibitors of the STAT1 protein?

Some activators or inhibitors of the STAT1 protein have been identified. These compounds can be used to study the function of the STAT1 protein and the development of disease treatments.

Is the STAT1 protein involved in the immune response to viral infection?

The STAT1 protein plays an important role in viral infection. It mediates interferon signaling, promotes antiviral immune responses, and inhibits viral replication and transmission.