Active Recombinant Human STAT1

Cat.No. : STAT1-1164H
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Cat. No. : STAT1-1164H
Description : Signal transducer and activator of transcription (STAT) proteins are a family of latent cytoplasmic transcription factors involved in cytokine, hormone, and growth factor signal transduction. Seven members of the STAT family of transcription factors have been identified in mammalian cells: STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6. Receptor-recruited STATs are phosphorylated on a single tyrosine residue in the carboxy terminal portion. The modified STATs are released from the cytoplasmic region of the receptor subunits to form homodimers or heterodimers through reciprocal interaction between the phosphotyrosine of one STAT and the SH2 domain of another. Following dimerization, STATs rapidly translocate to the nucleus and interact with specific regulatory elements to induce target gene transcription. Recently, STAT-1 has been implicated in modulating pro- and anti-apoptotic genes following several stressinduced responses. These effects are dependent on STAT-1 phosphorylation on serine-727 and require the C-terminal transactivation domain of STAT-1 to enhance its pro-apoptotic effect or inhibit its antiapoptotic effects. The STAT-1 C-terminal domain has been demonstrated to be important for protein-protein interaction with other transcriptional activators. The reports that STAT-1-deficient mice develop spontaneous and chemically induced tumours more rapidly compared to wildtype mice and that STAT-1-deficient cells are more resistant to agents that induce apoptosis strongly support the argument that STAT-1 acts as a tumour suppressor.
Source : Sf9 Insect cells.
Application : Use only for Research and not for Drug or Diagnostic purposes. STAT1 can be used for gel mobility shift assay, for protein-protein and small molecules-protein interactions assay.
Usage : For in vitro use only.
Form : Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT.
Activity : 1 ng is the amount sufficient for a gel mobility shift assay in a 20μl reaction, 100 ng are sufficient for a proteinprotein interaction assay detected by immuno-blot system.
Purity : > 95% by SDS-PAGE.
Storage : Quality guaranteed for 12 months, store at -80°C. Avoid freeze / thaw cycles.
Gene Name : STAT1 signal transducer and activator of transcription 1, 91kDa [ Homo sapiens ]
Synonyms : STAT1; signal transducer and activator of transcription 1, 91kDa; ISGF-3; STAT91; DKFZp686B04100; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription-1; transcription factor ISGF-3 components p91/p84
Gene ID : 6772
mRNA Refseq : NM_007315
Protein Refseq : NP_009330
MIM : 600555
UniProt ID : P42224
Chromosome Location : 2q32.2
Pathway : Chemokine signaling pathway; Jak-STAT signaling pathway; Pancreatic cancer; Toll-like receptor signaling pathway; Signaling by PDGF
Function : calcium ion binding; matopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity; protein binding; sequence-specific DNA binding; signal transducer activity; transcription factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the function of the STAT1 protein? 12/23/2019

STAT1 is a signal transduction and transcriptional activator involved in regulating a variety of biological processes such as cell growth, differentiation, apoptosis, and immune response.

Are mutations in genes associated with the STAT1 protein related to human disease? 09/21/2019

Mutations in the STAT1 gene have been found to be associated with a variety of diseases, including autoimmune diseases, primary immunodeficiency diseases, and malignant tumors.

What is the signaling pathway of STAT1 protein in immune cells? 09/01/2019

The STAT1 protein is primarily activated by the JAK-STAT signaling pathway. When activated by the receptor, JAK kinase phosphorylates the STAT1 protein, allowing it to form dimers and enter the nucleus to regulate transcription of related genes.

In which diseases does the STAT1 protein play an important role in the development of diseases? 07/16/2019

The STAT1 protein plays an important role in many diseases, including tumors, immune-related diseases (such as immunodeficiency diseases, autoimmune diseases), infectious diseases (such as viral infections), etc.

Are there activators or inhibitors of the STAT1 protein? 06/19/2019

Some activators or inhibitors of the STAT1 protein have been identified. These compounds can be used to study the function of the STAT1 protein and the development of disease treatments.

Is the STAT1 protein involved in the immune response to viral infection? 02/24/2019

The STAT1 protein plays an important role in viral infection. It mediates interferon signaling, promotes antiviral immune responses, and inhibits viral replication and transmission.

Customer Reviews (3)

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Reviews
04/22/2020

    It is well suited for our laboratory to induce specific immune responses.

    11/26/2019

      It has great application potential and performs well in all aspects.

      04/16/2019

        This protein has high yield and high purity, which greatly improves our production efficiency.

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