Recombinant Human STAT1 Protein

• Cat.No.: STAT1-040H
• Product Overview: Purified recombinant protein of Human signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant beta was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
• Source: E. coli
• Species: Human
• Molecular Mass: 83.3 kDa
• AA Sequence: GSHMSQWYELQQLDSKFLEQVHQLY DDSFPMEIRQYLAQWLEKQDWEHAA NDVSFATIRFHDLLSQLDDQYSRFS LENNFLLQHNIRKSKRNLQDNFQED PIQMSMIIYSCLKEERKILENAQRF NQAQSGNIQSTVMLDKQKELDSKVR NVKDKVMCIEHEIKSLEDLQDEYDF KCKTLQNREHETNGVAKSDQKQEQL LLKKMYLMLDNKRKEVVHKIIELLN VTELTQNALINDELVEWKRRQQSAC IGGPP
• Endotoxin: Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
• Purity: > 95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Supplied as a 0.2 µM filtered solution of PBS, pH 7.4

Gene Information

• Gene Name: STAT1 signal transducer and activator of transcription 1, 91kDa [ Homo sapiens ]
• Official Symbol: STAT1
• Synonyms: STAT1; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1-alpha/beta; ISGF 3; STAT91; transcription factor ISGF 3 components p91/p84; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1; CANDF7; ISGF-3; DKFZp686B04100
• Gene ID: 6772
• mRNA Refseq: NM_007315
• Protein Refseq: NP_009330
• MIM: 600555
• UniProt ID: P42224