Active GMP Recombinant Human CA9 protein

Cat.No. : CA9-804HG
Product Overview : GMP Recombinant Human CA9 protein(NP_001183.2)(376 aa), fused with His Tag at the C-terminal, was expressed in HEK293 cell in an animal component free process under cGMP guidelines.
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Source : HEK293
Species : Human
Form : Freeze-dried powder contains Sterile PBS (pH 7.4) with 6% mannitol.
Bio-activity : The specific activity is >200 pmol/min/ug, and 4-nitrophenylacetate is used for detection (routine test). One unit refers to the amount of enzyme that hydrolyzes 1.0 p mole of 4-nitrophenylacetic acid salt into 4-nitrophenol at pH 7.5 per minute at room temperature
Molecular Mass : Recombinant Human CA9 contains 376 aa. It has a predicted MW of 42.6 kDa.
Protein length : DNA sequence encoding Human Carbonic Anhydrase IX(NP_001207.2) was expressed with His tag at the C-terminal.
Endotoxin : <0.1EU/ug
Purity : >=95% by SDS-PAGE and HPLC
Storage : The lyophilized preparation can be stored at 4°C for 24 months, and the dissolved liquid can be stored at -20°C for 6-12 months to avoid repeated freezing and thawing
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : CA9 carbonic anhydrase IX [ Homo sapiens ]
Official Symbol : CA9
Synonyms : CAIX; CA9; CA-IX; G250; MN; P54/58N; pMW1
Gene ID : 768
mRNA Refseq : NM_001216
Protein Refseq : NP_001207
MIM : 603179
UniProt ID : Q16790

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What signaling pathways are known to regulate CA9 expression? 06/15/2022

The HIF-1 signaling pathway primarily regulates CA9 in response to cellular oxygen levels.

How does CA9 contribute to pH regulation within the tumor microenvironment? 02/02/2022

CA9 aids in extracellular acidification, promoting tumor cell survival and invasion in acidic tumor microenvironments.

How is CA9 expression regulated in hypoxic conditions? 04/15/2021

CA9 expression is upregulated by the hypoxia-inducible factor (HIF) under low oxygen conditions.

How are elevated levels of CA9 associated with cancer prognosis? 05/26/2020

Elevated CA9 levels often correlate with poor prognosis in various cancers due to its role in tumor adaptation to hypoxia.

What post-translational modifications have been identified on CA9? 11/23/2017

Potential modifications like glycosylation can be identified using techniques like mass spectrometry.

Are there specific inhibitors that target CA9, especially in cancer therapeutics? 09/29/2017

Several inhibitors, like acetazolamide derivatives, have been explored to target CA9 in cancer treatment.

What roles does CA9 play in tumor physiology? 07/06/2017

CA9 helps tumors survive in hypoxic conditions by regulating pH through the conversion of CO2 to bicarbonate and protons.

Customer Reviews (3)

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Reviews
08/04/2022

    Exceptional consistency, vital for our research's reliability.

    12/16/2021

      Critical support for our protein analysis and quantification.

      02/07/2021

        Unmatched accuracy in protein identification and sequencing.

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