Active GMP Recombinant Human CD86 protein
Cat.No. : | CD86-109HG |
Product Overview : | GMP Recombinant Human CD86 protein(NP_001193853)(221 aa), fused with His Tag at the C-terminal, was expressed in HEK293 cell in an animal component free process under cGMP guidelines. |
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Source : | HEK293 |
Species : | Human |
Form : | Freeze-dried powder contains Sterile PBS (pH 7.4) with 6% mannitol. |
Bio-activity : | The linear range of immobilized Human B7-2 (His Tag) at 5ug/mL(100 uL/well) that can bind to human CTLA-4(Fc Tag) is 20-200ng/mL. |
Molecular Mass : | Recombinant Human CD86 protein contains 221 aa. It has a predicted MW of 27.2 kDa. |
Protein length : | DNA sequence encoding Human B7-2(GenBank: AAH40261.1) was expressed with His tag at the C-terminal. |
Endotoxin : | <0.1EU/ug |
Purity : | >=95% by SDS-PAGE and HPLC |
Storage : | The lyophilized preparation can be stored at 4°C for 24 months, and the dissolved liquid can be stored at -20°C for 6-12 months to avoid repeated freezing and thawing |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | CD86 CD86 molecule [ Homo sapiens ] |
Official Symbol : | CD86 |
Synonyms : | CD86; B7-2; B70; CD28LG2; LAB72; MGC34413 |
Gene ID : | 942 |
mRNA Refseq : | NM_001206924 |
Protein Refseq : | NP_001193853 |
MIM : | 601020 |
UniProt ID : | P42081 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewWith the CD86 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.
Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.
The CD86 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.
Q&As (5)
Ask a questionYes, several clinical trials are investigating the efficacy of CD86 inhibitors in various diseases, including autoimmune disorders and certain cancers.
In transplantation, CD86 blockade is investigated as a potential strategy to modulate the immune response and prevent graft rejection by inhibiting excessive T cell activation.
CD86 signaling is involved in the differentiation of T helper cells. Modulating CD86 levels may influence the balance between Th1 and Th2 responses, which is relevant in various immune-mediated diseases.
There is emerging evidence suggesting that CD86 expression levels may have prognostic value in certain diseases, guiding clinicians in predicting disease outcomes.
CD86 signaling is involved in the development and function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune reactions.
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