Active GMP Recombinant Human IL18 Protein

• Cat.No.: IL18-01HG
• Product Overview: Recombinant human IL18 protein, was expressed in CHO-K1 cell-derived in an animal component free process under cGMP guidelines.

Specification

• Description: The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene
• Source: CHO-K1
• Species: Human
• Form: Lyophilized powder
• Endotoxin: <20 EU/mg
• Bio-activity: >5.0 x 10^4 IU/mg
• Purity: >95.0% by high performance liquid chromatography (SEC-HPLC) and SDS-PAGE.
• Storage Buffer: 10mM Phosphate-Buffered Saline (pH 7.2)
• Storage: Stable storage at 4℃ for 7-10 days; for long-term storage, please store at -20℃ after dispensing.
• Sterility: Sterility
• Instructions: It is recommended that lyophilized GMP rhIL18 be dissolved in water for injection or sterilized ultrapure water at a concentration of not less than 100 μg/ml, pending further dilution to working concentration.

Gene Information

• Gene Name: IL18 interleukin 18 [ Homo sapiens (human) ]
• Official Symbol: IL18
• Synonyms: IGIF; IL-18; IL-1g; IL1F4
• Gene ID: 3606
• mRNA Refseq: NM_001243211.2
• Protein Refseq: NP_001230140.1
• UniProt ID: Q14116
• MIM: 600953