• Official Full Name

    interleukin 18

  • Background

    The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011] Interleukin 18 (IL-18) is an 18-kDa cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24-kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-γ is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-γ activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-γ also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-γ. Pleiotropic effects of IL-18 have also been reported, such as, enhancement production of IFN-γ and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-γ in T cells, enhancement of Fas ligand expression by Th1 cells.
  • Synonyms

    IL18; interleukin 18; IGIF; IL-18; IL-1g; IL1F4; interleukin-18; IL-1 gamma; iboctadekin; interleukin-1 gamma; IFN-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); interferon-gamma-inducing factor;
    • Type:
    • Recombinant Proteins
    • Transfected Stable Cell Lines
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Goat
    • Horse
    • Human
    • Mouse
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Source :
    • CHO
    • CHO-K1
    • E.coli
    • E.coll
    • HEK293
    • HEK293F
    • HEK293T
    • Human
    • Human Cell
    • Mammalian Cell
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • His (Fc)
    • Avi
    • His(C
    • ter)
    • His|T7
    • Myc
    • DDK
    • MYC
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cattle IL18-873C Recombinant Cattle IL18 protein, His & T7-tagged E.coli His/T7
    Chicken IL18-6176C Recombinant Chicken IL18 Mammalian Cell His
    Chicken IL18-875C Recombinant Chicken IL18 protein, His-tagged E.coli His
    Cynomolgus Monkey IL18-385C Recombinant Cynomolgus IL18, His tagged E.coli His
    Dog IL18-874D Recombinant Dog IL18 protein, His-tagged E.coli His
    Dog IL18-01D Recombinant Dog Interleukin-18 E.coli N/A
    Equine IL18-208E Recombinant Equine IL18 E.coli N/A
    Goat IL18-1010G Recombinant Goat IL18 Protein, His-tagged E.coli N-His
    Horse IL18-1011H Recombinant Horse IL18 Protein, His-tagged E.coli N-His
    Human IL18-17H Human IL18 Reference standard N/A
    Human IL18-335H Active Recombinant Human IL18 (37-193aa) Human N/A
    Human IL18-500H Recombinant Human IL18 Mammalian Cell His
    Human IL18-1012H Recombinant Human IL18 Protein, His-tagged HEK293F N-His
    Human IL18-336H Active Recombinant Human IL18 protein E.coll N/A
    Human IL18-344HCL Recombinant Human IL18 lysate HEK293 N/A
    Human IL18-1237H Active Recombinant Human IL18 Yeast N/A
    Human IL18-2296H Recombinant Human IL18 Protein, His-tagged E.coli N-His
    Human IL18-574H Recombinant Human IL18, GST tagged E.coli His
    Human IL18-1941H Recombinant Human IL18, His-tagged E.coli His
    Human IL18-536H Recombinant Human Interleukin 18, His-tagged Human His
    Human IL18-2297H Recombinant Human IL18 Protein, His-tagged E.coli N-His
    Human IL18-546H Active Recombinant Human IL18, MIgG2a Fc-tagged CHO Fc
    Human IL18-504H Recombinant Human IL18 protein, His-Avi-tagged HEK293 His-Avi
    Human IL18-3886H Recombinant Human IL18 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL18-94H Recombinant Human IL18 Protein, His-tagged Human Cell His
    Human IL18-742H Recombinant Human Interleukin 18 (interferon-gamma-inducing factor) E.coli N/A
    Human IL18 -1575H Recombinant Human IL18 protein, Fc-tagged HEK293 Fc
    Human IL18-5756H Recombinant Human IL18 protein, His-tagged Yeast His
    Human IL18-551H Active Recombinant Human IL18, HIgG1 Fc-tagged CHO Fc
    Human IL18-153HG Active GMP Recombinant Human IL18 Protein HEK293
    Human IL18-547H Active Recombinant Human IL18, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL18-01HG Active GMP Recombinant Human IL18 Protein CHO-K1
    Human IL18-490H Active Recombinant Human IL18, His tagged Human Cell His
    Human IL18-5757H Recombinant Human IL18 protein, His-tagged Yeast His
    Human IL18-433H Active Recombinant Human Interleukin 18 Human N/A
    Human IL18-71H Recombinant Human IL18 Protein E.coli
    Human IL18-154H Recombinant Active Human IL18 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL18-1169H Recombinant Human IL18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL18-3681H Recombinant Human IL18 protein, GST-tagged E.coli GST
    Human IL18-155HG Active GMP Recombinant Human IL18 Protein E.coli N/A
    Human IL18-1169H-B Recombinant Human IL18 Protein Pre-coupled Magnetic Beads HEK293
    Human IL18-186H Active Recombinant Human IL18 Protein E.coli N/A
    Mouse Il18-1241M Recombinant Mouse Il18 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Il18-5441M Recombinant Mouse Il18 protein Yeast N/A
    Mouse IL18-639M Active Recombinant Mouse IL18, MIgG2a Fc-tagged CHO Fc
    Mouse Il18-5439M Recombinant Mouse Il18 protein, His-tagged Yeast His
    Mouse Il18-5440M Recombinant Mouse Il18 protein, His-tagged Yeast His
    Mouse II18-272M Active Recombinant Mouse Interleukin 18 E.coli N/A
    Mouse IL18-638M Active Recombinant Mouse IL18, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse Il18-740M Recombinant Mouse Interleukin 18, His-tagged E.coli His
    Mouse Il18-01M Active Recombinant Mouse Il18 Protein, His-Tagged E.coli His
    Mouse Il18-8667M Recombinant Mouse Il18, None tagged E.coli GST
    Mouse Il18-155M Recombinant Active Mouse IL18 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il18-1013M Recombinant Mouse Il18 Protein, His-tagged HEK293F N-His
    Mouse IL18-83M Recombinant Mouse IL-18 Yeast N/A
    Mouse Il18-3094M Recombinant Mouse Il18 protein, His-tagged E.coli His
    Pig IL18-876P Recombinant Pig IL18 protein, His & T7-tagged E.coli His/T7
    Porcine IL18-946P Active Recombinant Porcine IL18 Protein, His-tagged E.coli His
    Rabbit IL18-878R Recombinant Rabbit IL18 protein, His & T7-tagged E.coli His/T7
    Rat IL18-2686R Recombinant Rat IL18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat Il18-522R Recombinant Rat Interleukin 18 E.coli N/A
    Rat IL18-3031R Recombinant Rat IL18 Protein Mammalian Cell His
    Rat Il18-368I Recombinant Rat Il18 Protein (159 aa) E.coli
    Rat Il18-436R Active Recombinant Rat Il18 E.coli N/A
    Rat IL18-2686R-B Recombinant Rat IL18 Protein Pre-coupled Magnetic Beads HEK293
    Rat Il18-877R Recombinant Rat Il18 protein, His-tagged E.coli His
    Rhesus IL18-334R Recombinant Rhesus IL18 protein, His-tagged E.coli His
    Rhesus IL18-385R Recombinant Rhesus IL18, His tagged E.coli His
    Rhesus Macaque IL18-2057R-B Recombinant Rhesus Macaque IL18 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque IL18-2236R Recombinant Rhesus monkey IL18 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque IL18-370R Active Recombinant Rhesus Macaque IL18 E.coli N/A
    Rhesus Macaque IL18-2057R Recombinant Rhesus Macaque IL18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL18 Related Articles
    • IL18 Related Gene Family
    • IL18 Related Research Area

    IL18 involved in several pathways and played different roles in them. We selected most pathways IL18 participated on our site, such as Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionCCL4L1;KDRL;IL9R;CXCL12B;KITLGB;CCR8;CNTFR;IL28A;TNFRSF4
    NOD-like receptor signaling pathwayMAPK14B;MAPK12A;MAPK13;MAPK12B;MAPK11;TAB3;RELA;TAB2;CASP1
    Cytosolic DNA-sensing pathwayIFNA12;IL1B;IRF7;TBK1;CCL4L1;IFNA17;IFNA14;POLR3E;IFI202B
    Salmonella infectionWASF1;ARPC5L;IL8L2;RHOGC;NOS2A;RHOG;MAPK3;ARPC5LB;CCL3L3
    African trypanosomiasisIL18;PRKCA;THOP1;VCAM1;HBA-A2;IL1B;PLCB1;PLCB2;HBB-B1
    TuberculosisFCGR3A;IFNA12;IL1B;NOS2;HLA-DPA1;H2-AA;LBP;Il23a; Il12b;CARD9
    Inflammatory bowel disease (IBD)HLA-DRA;HLA-DRB4;IL21;HLA-DPB1;FOXP3;HLA-DPA1;HLA-DOA;HLA-DOB;HLA-DRB1
    Rheumatoid arthritisHLA-DRB5;IL17A;CD80;HLA-DMA;IL23;ATP6V1C2;HLA-DQB1;ATP6V0D1;ITGB2L

    IL18 has several biochemical functions, for example, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL18 itself. We selected most functions IL18 had, and list some proteins which have the same functions with IL18. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityIL22;IL5;RNF207B;IL10;CSF2;TGFB3;IL3;CER1;LFT2
    protein bindingNUMBL;RAB41;TOE1;SYCE2;PPIB;DUSP7;FAM69A;ERLIN2;TNNC2

    IL18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL18 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL18.

    IL18R1; CASK; Cul1

    Chen, GL; Fu, PF; et al. Immune Responses of Piglets Immunized by a Recombinant Plasmid Containing Porcine Circovirus Type 2 and Porcine Interleukin-18 Genes. VIRAL IMMUNOLOGY 27:521-528(2014).
    Ovsyannikova, IG; Pankratz, VS; et al. HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study. HUMAN GENETICS 133:1083-1092(2014).
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    How do researchers experimentally investigate the crosstalk between IL18 and other immune signaling pathways, such as Toll-like receptor signaling? 10/28/2022

    Co-immunoprecipitation, co-localization studies, and pathway inhibition assays decipher IL18's interactions with signaling molecules and pathways.

    What assays and methodologies are employed to evaluate the potential therapeutic interventions targeting IL18 in autoimmune diseases and chronic inflammation? 03/23/2022

    Therapeutic antibody trials, in vitro drug screens, and disease model assessments assess IL18-targeted interventions in autoimmune diseases.

    How are animal models and in vivo imaging techniques used to understand the kinetics of IL18-mediated immune responses and its tissue-specific effects? 01/10/2022

    Xenograft models, intravital imaging, and tissue-specific knockout approaches unravel IL18's kinetics and effects within complex in vivo environments.

    Can you elaborate on the techniques used to assess the impact of IL18 on immune cell activation, migration, and effector functions? 06/11/2021

    Flow cytometry, chemotaxis assays, and functional cell assays examine IL18's impact on immune cell activation, migration, and effector functions.

    Can you explain the experimental strategies used to analyze the interactions between IL18 and its receptor complex, as well as the downstream signaling events triggered by receptor engagement? 01/12/2021

    Surface plasmon resonance, mutational studies, and phosphoproteomics illuminate IL18's receptor interactions and downstream signal transduction pathways.

    How are cellular and molecular techniques employed to investigate IL18's role in regulating the balance between Th1 and Th2 immune responses? 08/01/2020

    Immunophenotyping, cytokine profiling, and gene expression analyses elucidate IL18's influence on Th cell polarization and immune balance.

    What experimental approaches are utilized to study the genetic and epigenetic regulation of IL18 expression in response to different stimuli? 04/29/2020

    ChIP assays, promoter analyses, and epigenetic profiling uncover the regulatory mechanisms underlying IL18 gene expression dynamics.

    What methods are used to dissect the mechanisms through which IL18 contributes to the pathogenesis of inflammatory diseases and its interactions with other proinflammatory molecules? 12/15/2018

    Disease models, knockout mice, and co-stimulation studies explore IL18's involvement in inflammatory conditions and its interplay with other proinflammatory mediators.

    How do researchers investigate the role of IL18 in modulating the tumor microenvironment and its potential implications for cancer immunotherapy? 11/05/2018

    Tumor models, immune profiling, and immunotherapeutic studies investigate IL18's modulation of the tumor microenvironment and its implications for cancer therapy.

    Could you explain the experimental strategies used to characterize the inflammasome activation triggered by IL18 and its downstream effects on cytokine production? 04/20/2018

    Caspase assays, cytokine ELISAs, and microscopy techniques unveil the activation of inflammasomes and IL18's contribution to pyroptosis and cytokine storms.

    Customer Reviews (3)

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      Effective in inflammation models. -


        High stability in serum. -


          Suitable for ELISA. -

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