IL18 Protein


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Official Full Name interleukin 18
Background The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011] Interleukin 18 (IL-18) is an 18-kDa cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24-kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-γ is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-γ activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-γ also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-γ. Pleiotropic effects of IL-18 have also been reported, such as, enhancement production of IFN-γ and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-γ in T cells, enhancement of Fas ligand expression by Th1 cells.
Synonyms IL18; interleukin 18; IGIF; IL-18; IL-1g; IL1F4; interleukin-18; IL-1 gamma; iboctadekin; interleukin-1 gamma; IFN-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); interferon-gamma-inducing factor
    • Species :
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Goat
    • Horse
    • Human
    • Mouse
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • E.coll
    • HEK293
    • HEK293F
    • HEK293T
    • Human
    • Human Cell
    • Mammalian Cell
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • T7
    • His-Avi
    • Myc/DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL18-1237H Recombinant Human IL18 Yeast N/A
    Human IL18-186H Recombinant Human IL18 Protein E.coli N/A
    Human IL18-1941H Recombinant Human IL18, His-tagged E.coli His
    Human IL18-335H Recombinant Human IL18 (37-193aa) Human N/A
    Human IL18-336H Recombinant Human IL18 protein E.coll N/A
    Human IL18-433H Recombinant Human Interleukin 18 Human N/A
    Human IL18-490H Recombinant Human IL18, His tagged Human Cell His
    Human IL18-500H Recombinant Human IL18 Mammalian Cell His
    Human IL18-536H Recombinant Human Interleukin 18, His-tagged Human His
    Human IL18-546H Recombinant Human IL18, MIgG2a Fc-tagged CHO Fc
    Human IL18-547H Recombinant Human IL18, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL18-551H Recombinant Human IL18, HIgG1 Fc-tagged CHO Fc
    Human IL18-574H Recombinant Human IL18, GST tagged E.coli His
    Human IL18-742H Recombinant Human Interleukin 18 (interferon-gamma-inducing factor) E.coli N/A
    Mouse II18-272M Recombinant Mouse Interleukin 18 E.coli N/A
    Mouse IL18-638M Recombinant Mouse IL18, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse IL18-639M Recombinant Mouse IL18, MIgG2a Fc-tagged CHO Fc
    Mouse Il18-740M Recombinant Mouse Interleukin 18, His-tagged E.coli His
    Mouse IL18-83M Recombinant Mouse IL-18 Yeast N/A
    Mouse Il18-8667M Recombinant Mouse Il18, None tagged E.coli GST
    Rat IL18-3031R Recombinant Rat IL18 Protein Mammalian Cell His
    Rat Il18-436R Recombinant Rat Il18 E.coli N/A
    Rat Il18-522R Recombinant Rat Interleukin 18 E.coli N/A
    Rat Il18-877R Recombinant Rat Il18 protein, His-tagged E.coli His
    Cynomolgus Monkey IL18-385C Recombinant Cynomolgus IL18, His tagged E.coli His
    Rhesus Macaque IL18-2236R Recombinant Rhesus monkey IL18 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque IL18-370R Recombinant Rhesus Macaque IL18 E.coli N/A
    Dog IL18-01D Recombinant Dog Interleukin-18 E.coli N/A
    Dog IL18-874D Recombinant Dog IL18 protein, His-tagged E.coli His
    Chicken IL18-6176C Recombinant Chicken IL18 Mammalian Cell His
    Chicken IL18-875C Recombinant Chicken IL18 protein, His-tagged E.coli His
    Rabbit IL18-878R Recombinant Rabbit IL18 protein, His & T7-tagged E.coli His/T7
    Equine IL18-208E Recombinant Equine IL18 E.coli N/A
    Cattle IL18-873C Recombinant Cattle IL18 protein, His & T7-tagged E.coli His/T7
    Pig IL18-876P Recombinant Pig IL18 protein, His & T7-tagged E.coli His/T7
    Porcine IL18-946P Recombinant Porcine IL18 Protein, His-tagged E.coli His
    Human IL18-344HCL Recombinant Human IL18 lysate HEK293 N/A
    Goat IL18-1010G Recombinant Goat IL18 Protein, His-tagged E.coli N-His
    Horse IL18-1011H Recombinant Horse IL18 Protein, His-tagged E.coli N-His
    Human IL18-1012H Recombinant Human IL18 Protein, His-tagged HEK293F N-His
    Mouse Il18-1013M Recombinant Mouse Il18 Protein, His-tagged HEK293F N-His
    Human IL18-2296H Recombinant Human IL18 Protein, His-tagged E.coli N-His
    Human IL18-2297H Recombinant Human IL18 Protein, His-tagged E.coli N-His
    Mouse Il18-3094M Recombinant Mouse Il18 protein, His-tagged E.coli His
    Human IL18-3681H Recombinant Human IL18 protein, GST-tagged E.coli GST
    Mouse Il18-5439M Recombinant Mouse Il18 protein, His-tagged Yeast His
    Mouse Il18-5440M Recombinant Mouse Il18 protein, His-tagged Yeast His
    Mouse Il18-5441M Recombinant Mouse Il18 protein Yeast N/A
    Human IL18-5756H Recombinant Human IL18 protein, His-tagged Yeast His
    Human IL18-5757H Recombinant Human IL18 protein, His-tagged Yeast His
    Human IL18-153HG GMP Recombinant Human IL18 Protein HEK293
    Human IL18-17H Human IL18 Reference standard N/A
    Human IL18-3886H Recombinant Human IL18 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL18-504H Recombinant Human IL18 protein, His-Avi-tagged HEK293 His-Avi
    Mouse Il18-1241M Recombinant Mouse Il18 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    IL18 involved in several pathways and played different roles in them. We selected most pathways IL18 participated on our site, such as Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction Ifna15; OSM; TNFRSF10B; CXCL9; IL18RAP; CRFB2; IL13; IL13RA1; PDGFRA; TGFB1
    NOD-like receptor signaling pathway IL-8; IL8L2; CARD9; SGUT1; MAP3K7; IL8L1; MAPK12; TAB3; PSTPIP1B; MAPK1
    Cytosolic DNA-sensing pathway NFKBIA; IFNA7; MAVS; POLR3B; POLR1D; IFNA12; POLR3GL; IFNA4; NFKBIAA; NFKBIB
    Salmonella infection PFN4; ACTB2; CCL4; MAPK3; PFN3; ROCK1; IL1A; RHOGC; MAPK8A; RILP
    Legionellosis EEF1A1; IL18; HSPA1L; TLR5; C3; PYCARD; HSF1; SAR1B; ITGB2L; IL12B
    African trypanosomiasis HPR; PLCB2; IL1B2; IFNG; LAMA4; FAS; HBA-A2; HBB-B2; PRKCB; HBB-B1
    Malaria TGFB2; IL6; THBS3; IL1B; MYD88; THBS2; COMP; TLR9; TLR2; LRP1
    Tuberculosis SPHK1; FCGR3B; PLK3; FCGR2C; HLA-DQA2; CASP9; EEA1; RAB5C; MAPK10; TGFB2
    Inflammatory bowel disease (IBD) IL18R1; Il2; STAT6; IL13; IFNG; HLA-DPA1; IL4R; H2-AA; HLA-DPB1; HLA-DRA
    Rheumatoid arthritis TLR4; ATP6V0D2; TNFSF13; CCL3L1; ITGB2; ATP6V0E2; HLA-DQB1; ATP6V1A; ATP6V1D; ATP6V1C1

    IL18 has several biochemical functions, for example, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL18 itself. We selected most functions IL18 had, and list some proteins which have the same functions with IL18. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity IL15L; IL34; TGFB3; BMP7B; TNFSF12; HMGB1A; VSTM1; TNFSF8; Il2; CMTM6
    protein binding UGP2; STX4A; MAPK4; TRIM26; WDR34; VSIG4; GPN3; ARGLU1; RAB18; MMS22L

    IL18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL18 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL18.

    IL18R1; CASK; Cul1

    Chen, GL; Fu, PF; et al. Immune Responses of Piglets Immunized by a Recombinant Plasmid Containing Porcine Circovirus Type 2 and Porcine Interleukin-18 Genes. VIRAL IMMUNOLOGY 27:521-528(2014).
    Ovsyannikova, IG; Pankratz, VS; et al. HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study. HUMAN GENETICS 133:1083-1092(2014).


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