Active GMP Recombinant Mouse Cxcl9 Protein, His-Tagged

• Cat.No.: Cxcl9-01M
• Product Overview: GMP Recombinant Mouse Cxcl9 Protein, His-Tagged was expressed in Escherichia coli cell-derived in an animal component free process under cGMP guidelines.

Specification

• Description: Predicted to enable CXCR3 chemokine receptor binding activity and chemokine activity. Acts upstream of or within several processes, including defense response to virus; positive regulation of myoblast differentiation; and positive regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in central nervous system; retina; stomach; testis; and thymus. Orthologous to human CXCL9 (C-X-C motif chemokine ligand 9).
• Source: Escherichia coli
• Species: Mouse
• Tag: His
• Form: Lyophilized
• Bio-activity: Measure by its ability to chemoattract BaF3 cells transfected with mouse CXCR3. The ED50 for this effect is <0.3 μg/mL.
• AA Sequence: TLVIRNARCSCISTSRGTIHYKSLK DLKQFAPSPNCNKTEIIATLKNGDQ TCLDPDSANVKKLMKEWEKKINQKK KQKRGKKHQKNMKNRKP
  KTPQSRRRSRKTT with polyhistidine tag at the N-terminus
• Endotoxin: <0.1 EU per 1 μg of the protein by the LAL method.
• Purity: >98% as determined by SDS-PAGE. Ni-NTA chromatography
• Notes: Please use within one month after protein reconstitution.
• Storage: Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.
• Storage Buffer: The protein was lyophilized from a solution containing 1X PBS, pH 7.4.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

Gene Information

• Gene Name: Cxcl9 chemokine (C-X-C motif) ligand 9 [ Mus musculus (house mouse) ]
• Official Symbol: Cxcl9
• Synonyms: CMK; Mig; MuMIG; Scyb9; crg-10
• Gene ID: 17329
• mRNA Refseq: NM_008599.4
• Protein Refseq: NP_032625.2
• UniProt ID: P18340

Reviews

02/21/2023

Customer service promptly feedback my requests, technical staff timely solve the problems that arise.

04/01/2022

The protein composition was stable and the concentration was high, which allowed me to obtain satisfactory experimental results.

Q&As

What is the relationship between CXCL9 and the chemokine receptor CXCR3?

CXCL9 can bind specifically to CXCR3 and accumulate at sites of inflammation, thereby inducing and exacerbating the inflammatory response.

Do you offer CXCL9 fused with other tags?

Yes, we will provide you with the most suitable labels according to your experimental needs.

Can CXCL9 be detected in lymphoid tissue under normal physiological conditions?

No, CXCL9 can only be detected when the organism is inflamed or infected.

CXCL9 is secreted by which cells?

CXCL9 is mainly secreted by endothelial cells and monocytes.

What diseases has CXCL9 been closely associated with the study of?

CXCL9 has been linked to pulmonary embolism, asthma and breast cancer research.