Active Recombinant Bovine Interleukin 23, Alpha Subunit P19
Cat.No. : | IL23A-239B |
Product Overview : | Recombinant Bovine IL-23 alpha subunit p19 was expressed inYeast.MW= 19.0 kDa (171 aa). |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL23A-239B |
Description : | Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. This gene encodes the p19 subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. |
Source : | Yeast. |
Formulation/ Reconstitution : | Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. |
Purification : | Ion-exchange chromatography. |
Purity : | >95% as visualized by SDS-PAGE analysis. |
Amino Acid Sequence : | RAVSEDSSPA WTRGQQLSQQ LCMLAWSAHL PMGHMDLPRE EGGDKTTDDV PRIQCEDGCD PQGLRDNSQS CLQRIHRGLV FYEKLLGSDI FTGEPSLLPN GPVDQLHASI LGLRELLQPK GHHWETEQTP SPIPSQPWQR LLLRLKILRS LQAFVAVAAR VFAHGAATLS P. |
Bioactivity : | The biological activity of recombinant bovine IL-23, alpha subunit p19 has not been tested. The active form of IL-23 is a dimer (p19/p40). |
Stability And Storage : | Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles. |
Gene Name : | IL23A interleukin 23, alpha subunit p19 [ Bos taurus ] |
Synonyms : | interleukin 23, alpha subunit p19; IL23A; IL-23 |
Gene ID : | 511022 |
mRNA Refseq : | XM_588269.4 |
Protein Refseq : | XP_588269.2 |
Chromosome Location : | 5 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionPlease inquiry our product manager with specific product.
Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.
IL23A primarily plays a role in regulating the adaptive immune response.
IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.
In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.
IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.
Customer Reviews (3)
Write a reviewCoupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.
Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.
Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.
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