Active Recombinant Full Length Human UMPS Protein, C-Flag-tagged
Cat.No. : | UMPS-339HFL |
Product Overview : | Recombinant Full Length Human UMPS Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Bio-activity : | UMPS activity is verified in a bioassay |
Molecular Mass : | 52 kDa |
AA Sequence : | MAVARAALGPLVTGLYDVQAFKFGD FVLKSGLSSPIYIDLRGIVSRPRLL SQVADILFQTAQNAGISFDT VCGVPYTALPLATVICSTNQIPMLI RRKETKDYGTKRLVEGTINPGETCL IIEDVVTSGSSVLETVEVLQ KEGLKVTDAIVLLDREQGGKDKLQA HGIRLHSVCTLSKMLEILEQQKKVD AETVGRVKRFIQENVFVAAN HNGSPLSIKEAPKELSFGARAELPR IHPVASKLLRLMQKKETNLCLSADV SLARELLQLADALGPSICML KTHVDILNDFTLDVMKELITLAKCH EFLIFEDRKFADIGNTVKKQYEGGI FKIASWADLVNAHVVPGSGV VKGLQEVGLPLHRGCLLIAEMSSTG SLATGDYTRAAVRMAEEHSEFVVGF ISGSRVSMKPEFLHLTPGVQ LEAGGDNLGQQYNSPQEVIGKRGSD IIIVGRGIISAADRLEAAEMYRKAA WEAYLSRLGVTRTRPLEQKLISEED LAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism |
Gene Name : | UMPS uridine monophosphate synthetase [ Homo sapiens (human) ] |
Official Symbol : | UMPS |
Synonyms : | OPRT |
Gene ID : | 7372 |
mRNA Refseq : | NM_000373.4 |
Protein Refseq : | NP_000364.1 |
MIM : | 613891 |
UniProt ID : | P11172 |
Products Types
◆ Recombinant Protein | ||
Umps-6834M | Recombinant Mouse Umps Protein, Myc/DDK-tagged | +Inquiry |
UMPS-4917R | Recombinant Rhesus Macaque UMPS Protein, His (Fc)-Avi-tagged | +Inquiry |
UMPS-9907M | Recombinant Mouse UMPS Protein, His (Fc)-Avi-tagged | +Inquiry |
UMPS-2315H | Recombinant Human UMPS Protein, His (Fc)-Avi-tagged | +Inquiry |
UMPS-212H | Recombinant Human UMPS Protein, His-tagged | +Inquiry |
◆ Lysates | ||
UMPS-503HCL | Recombinant Human UMPS 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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