Active Recombinant Human BMP15 Protein

• Cat.No.: BMP15-010H
• Product Overview: The mature recombinant human BMP-15 protein consists of 125 amino acids (268-392) without tag was expressed in E. coli.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure.
• Source: E. coli
• Species: Human
• Bio-activity: Measured by its ability to induce Smad3 phosphorylation in P19 mouse embryonal carcinoma cells. Approximately 10 ng/mL can effectively induce Smad3 phosphorylation.
• Molecular Mass: 14 kDa
• Product-Related Proteins: 268-392
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: BMP15 bone morphogenetic protein 15 [ Homo sapiens (human) ]
• Official Symbol: BMP15
• Synonyms: BMP15; bone morphogenetic protein 15; ODG2; POF4; GDF9B; bone morphogenetic protein 15; growth/differentiation factor 9B
• Gene ID: 9210
• mRNA Refseq: NM_005448
• Protein Refseq: NP_005439
• MIM: 300247
• UniProt ID: O95972