Active Recombinant Human CD28, Fc-tagged, Biotinylated
Cat.No. : | CD28-566H |
Product Overview : | The recombinant human CD28-Fc fusion is expressed as a 362-amino acid protein consisting of Asn19 - Pro152 region of CD28 (UniProt accession #P10747) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition. |
- Specification
- Gene Information
- Related Products
Source : | Human cells |
Species : | Human |
Tag : | Fc |
Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier and preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule). |
Bio-activity : | Binds to human B7 family ligands, CD80/B7-1 and CD86/B7-2 as well as anti-CD28 monoclonal antibody, human IgG1 with high affinity (KD< 1 nm) determined by elisa. inhibit il-2 secretion in stimulated human jurkat t cell cells.> |
Molecular Mass : | Calculated molecular mass 40.7 kDa; estimated by SDS-PAGE under reducing condition 55-60 kDa probably due to glycosylation |
AA Sequence : | NKILVKQSPMLVAYDNAVNLSCKYS YNLFSREFRASLHKGLDSAVEVCVV YGNYSQQLQVYSKTGFNCDGKLGNE SVTFYLQNLYVNQTDIYFCKIEVMY PPPYLDNEKSNGTIIHVKGKHLCPS PLFPGPSKPSTGTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEV TCVVVDVSHEDPEVKFNWYVDGVEV HNAKTKPREEQYNSTYRVVSVLTV LHQDWLNGKEYKCKVSNKALPAPIE KTISKAKGQPREPQVYTLPPSREEM TKNQVSLTCLVKGFYPSDIAVEWE SNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEAL HNHYTQKSLSLSPGK |
Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the |
Purity : | >95% judged by SDS-PAGE under reducing condition |
Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
Gene Name : | CD28 CD28 molecule [ Homo sapiens ] |
Official Symbol : | CD28 |
Synonyms : | CD28; CD28 molecule; CD28 antigen (Tp44); T-cell-specific surface glycoprotein CD28; T cell specific surface glycoprotein; CD28 antigen; Tp44; MGC138290; |
Gene ID : | 940 |
mRNA Refseq : | NM_001243077 |
Protein Refseq : | NP_001230006 |
MIM : | 186760 |
UniProt ID : | P10747 |
Chromosome Location : | 2q33 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; |
Function : | SH3/SH2 adaptor activity; coreceptor activity; identical protein binding; protease binding; protein binding; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
CD28-135C | Recombinant Cynomolgus Monkey CD28 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD28-902R | Recombinant Rat CD28 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD28-32H | Active Recombinant Human CD28 protein, Biotin-labelled | +Inquiry |
CD28-667H | Recombinant Human CD28 Protein, His-tagged | +Inquiry |
Cd28-666M | Recombinant Mouse Cd28 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CD28-2002MCL | Recombinant Mouse CD28 cell lysate | +Inquiry |
CD28-2013HCL | Recombinant Human CD28 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1705 | CD28:B7-1[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket