CD28

  • Official Full Name

    CD28 CD28 molecule

  • Synonyms

    CD28; CD28 molecule; CD28 antigen (Tp44); T-cell-specific surface glycoprotein CD28; T cell specific surface glycoprotein; CD28 antigen; Tp44; MGC138290;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chromatography Reagents
  • Assay Kits
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Felis catus (Cat) (Felis silvestris catus)
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Human / Cynomolgus / Rhesus Monkey
  • Human/Cynomolgus
  • Human/Cynomolgus/Rhesus macaque
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • CHO
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Avi|Fc
  • C
  • Fc
  • hFc
  • DDK|His
  • Avi
  • His
  • Fc|His
  • His(C
  • ter)
  • GST
  • HIgG
  • His (Fc)
  • His|Flag|StrepII
  • His|GST
  • human|IgG1|Fc
  • LEVLFQ
  • mFc
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD28-566H Active Recombinant Human CD28, Fc-tagged, Biotinylated Human Cell Fc
Human CD28-3908H Active Recombinant Human CD28 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
Human CD28-378H Active Recombinant Human CD28, HIgG1 Fc-tagged CHO Fc
Human CD28-212H Active Recombinant Human CD28, MIgG2a Fc-tagged CHO Fc
Human CD28-051H Active Recombinant Human CD28 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi
Human CD28-01H Active Recombinant Human CD28 protein, hIgG-His-tagged Insect Cell HIgG/His
Human CD28-181H Recombinant Human CD28 Protein, DDK/His-tagged HEK293 DDK/His
Human CD28-1593H Recombinant Human CD28 Molecule Mammalian cells N/A
Human CD28-0773H Active Recombinant Human CD28 Protein, His-Flag-StrepII-Tagged Human Cell His/Flag/StrepII
Human CD28-321H Recombinant Human CD28 Protein HEK293 N/A
Human CD28-182H Recombinant Human CD28 Protein, Fc-tagged HEK293 Fc
Human CD28-3909H Recombinant Human CD28, Fc tagged Human Cell Fc
Human CD28-142H Recombinant Human CD28, Fc-tagged CHO Fc
Human CD28-32H Active Recombinant Human CD28 protein, Biotin-labelled CHO N/A
Human CD28-3910H Recombinant Human CD28, His tagged Human Cell His
Human CD28-0772H Recombinant Human CD28 Protein Wheat Germ N/A
Human CD28-0774H Recombinant Human CD28 Protein, GST-Tagged Wheat Germ GST
Human CD28-2013HCL Recombinant Human CD28 cell lysate Human Cell N/A
Human CD28-3095HF Recombinant Full Length Human CD28 Protein, GST-tagged In Vitro Cell Free System GST
Human CD28-3909HAF555 Recombinant Human CD28 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Human CD28-336H Active Recombinant Human/Cynomolgus/Rhesus macaque CD28 protein, mFc-tagged, low endotoxin HEK293 mFc
Human CD28-332HG Active GMP Recombinant Human CD28 protein, Fc-tagged HEK293 Fc
Human CD28-667H Recombinant Human CD28 Protein, His-tagged HEK293F N-His
Human CD28-321HAF647 Recombinant Human CD28 Protein, Alexa Fluor 647 conjugated HEK293 LEVLFQ
Human CD28-3909HAF488 Recombinant Human CD28 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Human CD28-321HAF488 Recombinant Human CD28 Protein, Alexa Fluor 488 conjugated HEK293 LEVLFQ
Human CD28-668H Recombinant Human CD28 Protein, His&SUMO-tagged HEK293F N-His&SUMO
Human CD28-4376H-B Recombinant Human CD28 Protein Pre-coupled Magnetic Beads HEK293
Human CD28-321HAF555 Recombinant Human CD28 Protein, Alexa Fluor 555 conjugated HEK293 LEVLFQ
Human CD28-4995H Recombinant Human CD28 protein, hFc-tagged HEK293 hFc
Human CD28-747HB Recombinant Human CD28 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Human CD28-1379H Recombinant Human CD28 Protein (Asn19-Pro152), N-His tagged E.coli N-His
Human CD28-3909HAF647 Recombinant Human CD28 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Human CD28-503M CD28 protein-coupled magnetic MicroBeads
Human CD28-747H Recombinant Human CD28 protein, His-Avi-tagged HEK293 His-Avi
Human CD28-1605H Recombinant Human CD28 Protein (Met1-Pro152), C-Fc tagged Mammalian cells C-Fc
Human CD28-321HF Recombinant Human CD28 Protein, FITC conjugated HEK293 LEVLFQ
Human CD28-322H Recombinant Human CD28 Protein (Asn19-Pro152), N-His-SUMO tagged, Animal-free, Carrier-free HEK293 N-His-SUMO
Human CD28-151H Recombinant Human CD28 Protein, His-tagged Human Cells His
Human CD28-3909HF Recombinant Human CD28 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Human CD28-3092HF Recombinant Full Length Human CD28 Protein In Vitro Cell Free System
Human CD28-4376H Recombinant Human CD28 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CD28-232M Active Recombinant Mouse CD28, MIgG2a Fc-tagged CHO Fc
Mouse Cd28-4008M Recombinant Mouse Cd28 protein, His-tagged HEK293 His
Mouse Cd28-1712M Recombinant Mouse CD28 Antigen, Fc-His Mammalian cells Fc/His
Mouse Cd28-661M Recombinant Mouse Cd28 protein, His & GST-tagged E.coli His/GST
Mouse CD28-640M Recombinant Mouse CD28, Fc-His tagged Human Cell Fc/His
Mouse CD28-2002MCL Recombinant Mouse CD28 cell lysate Human Cell N/A
Mouse Cd28-4008MAF555 Recombinant Mouse Cd28 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Mouse Cd28-4008MAF647 Recombinant Mouse Cd28 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Mouse CD28-640MAF488 Recombinant Mouse CD28 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
Mouse CD28-640MAF555 Recombinant Mouse CD28 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
Mouse Cd28-4008MF Recombinant Mouse Cd28 Protein, His-tagged, FITC conjugated HEK293 His
Mouse CD28-339M Recombinant Mouse CD28 protein, Fc-tagged HEK293 human/IgG1/Fc
Mouse Cd28-666M Recombinant Mouse Cd28 Protein, His-tagged E.coli N-His
Mouse CD28-640MAF647 Recombinant Mouse CD28 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
Mouse CD28-625M Recombinant Mouse CD28 Protein, Fc-tagged HEK293 Fc
Mouse Cd28-4008MAF488 Recombinant Mouse Cd28 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Mouse CD28-640MF Recombinant Mouse CD28 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
Mouse Cd28-157M Recombinant Mouse Cd28 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cd28-28M Recombinant Mouse CD28 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter)
Mouse CD28-624M Recombinant Mouse CD28 Protein HEK293
Mouse Cd28-157M-B Recombinant Mouse Cd28 Protein Pre-coupled Magnetic Beads HEK293
Rat CD28-1100R Recombinant Rat CD28 Protein, His-tagged HEK293 His
Rat CD28-1099R Recombinant Rat CD28 Protein, Fc-tagged HEK293 Fc
Rat CD28-1244R Recombinant Rat CD28 Protein Mammalian Cell His
Rat CD28-1099RAF488 Recombinant Rat CD28 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Rat CD28-1099RAF555 Recombinant Rat CD28 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Rat CD28-1100RAF488 Recombinant Rat CD28 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Rat CD28-1876R Active Recombinant Rat CD28 protein, His-tagged HEK293 His
Rat CD28-902R-B Recombinant Rat CD28 Protein Pre-coupled Magnetic Beads HEK293
Rat CD28-1100RAF555 Recombinant Rat CD28 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Rat CD28-902R Recombinant Rat CD28 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CD28-1099RAF647 Recombinant Rat CD28 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Rat CD28-1100RAF647 Recombinant Rat CD28 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Rat CD28-1099RF Recombinant Rat CD28 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Rat CD28-1100RF Recombinant Rat CD28 Protein, His-tagged, FITC conjugated HEK293 His
Rat Cd28-669R Recombinant Rat Cd28 Protein, His-tagged E.coli N-His
Monkey CD28-1204CAF555 Recombinant Monkey CD28 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Monkey CD28-1204CAF647 Recombinant Monkey CD28 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Monkey CD28-1204CAF488 Recombinant Monkey CD28 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Monkey CD28-1204CF Recombinant Monkey CD28 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Cynomolgus CD28-1204C Active Recombinant Cynomolgus CD28 protein(Met1-Pro152), hFc-tagged HEK293 C-hFc
Cynomolgus Monkey CD28-387C Recombinant Cynomolgus CD28 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CD28-135C Recombinant Cynomolgus Monkey CD28 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CD28-135C-B Recombinant Cynomolgus Monkey CD28 Protein Pre-coupled Magnetic Beads HEK293
Felis catus (Cat) (Felis silvestris catus) RFL13001FF Recombinant Full Length Cat T-Cell-Specific Surface Glycoprotein Cd28(Cd28) Protein, His-Tagged E.coli expression system His
Gallus gallus (Chicken) RFL10568GF Recombinant Full Length Chicken T-Cell-Specific Surface Glycoprotein Cd28 Homolog(Cd28) Protein, His-Tagged E.coli expression system His
Homo sapiens (Human) RFL24979HF Recombinant Full Length Human T-Cell-Specific Surface Glycoprotein Cd28(Cd28) Protein, His-Tagged E.coli expression system His
Human / Cynomolgus / Rhesus Monkey CD28-338H Active Recombinant Human / Cynomolgus / Rhesus Monkey CD28 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
Human/Cynomolgus CD28-339H Recombinant Human/Cynomolgus CD28(Asn19-Pro152) Protein, N-6*His-tagged HEK293 His
Human/Cynomolgus/Rhesus macaque CD28-337H Recombinant Human/Cynomolgus/Rhesus macaque CD28 protein, His-tagged HEK293 His
Human/Cynomolgus/Rhesus macaque CD28-562H Recombinant Human/Cynomolgus/Rhesus macaque CD28 protein, Fc-tagged (HPLC-verified) HEK293 human/IgG1/Fc
Mus musculus (Mouse) RFL5884MF Recombinant Full Length Mouse T-Cell-Specific Surface Glycoprotein Cd28(Cd28) Protein, His-Tagged E.coli expression system His
Oryctolagus cuniculus (Rabbit) RFL29096OF Recombinant Full Length Rabbit T-Cell-Specific Surface Glycoprotein Cd28(Cd28) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL17688RF Recombinant Full Length Rat T-Cell-Specific Surface Glycoprotein Cd28(Cd28) Protein, His-Tagged E.coli expression system His
Rhesus Macaque CD28-733R Recombinant Rhesus monkey CD28 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD28-559R-B Recombinant Rhesus Macaque CD28 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD28-559R Recombinant Rhesus Macaque CD28 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CD28-6863C Recombinant Chicken CD28 Mammalian Cell His
Kit-1705 CD28:B7-1[Biotinylated] Inhibitor Screening Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD28 Related Articles
  • CD28 Related Gene Family
  • CD28 Related Research Area

CD28 involved in several pathways and played different roles in them. We selected most pathways CD28 participated on our site, such as Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)HLA-C;ICAM2;LRRC4C;SDC4;CLDN11A;PTPRM;BMA2;CLDN1;L1CAM
T cell receptor signaling pathwaySLA1;PRKCQ;MAPK3;PIK3R1;IKBKG;PTPN6;MAP2K1;VAV2;NFATC2
Intestinal iBLA;MAP3K14;CXCL12B;CXCL12;CCL27B;HLA-DMA;CCR10;MHC2A;LTBR
ne network for IgA productionIL6;IL-15RA;CCR9A;CD40;Icosl;HLA-DQA1;CXCR4B;LTBR;CXCR4A
Type I diabetes mellitusIL12A;IL12B;HLA-DMB;HLA-G;GAD2;HLA-DPB1;Fasl;FAS;INS
MeaslesIFNA14;EIF2AK4;RELA;IRAK4;MAVS;IFNA1;EIF3H;IFNA12;IFNA2
AutoiIFNA10;IFNA21;HLA-DPA1;TPO;Ifna15;HLA-DOB;TSHR;HLA-DRB4;HLA-DQB1
ne thyroid diseaseFAS;IFNA4;H2-AB1;HLA-DRA;IFNA1;HLA-DQB1;Fasl;HLA-B;IFNA13
Systemic lupus erythematosusHIST1H2AH;H2AFZ;HIST1H2BQ;IFNG;HLA-DPA1;HLA-DRB4;Hc;HLA-DOA;HIST2H2AA4
Rheumatoid arthritisCD86;MMP3;ATP6V0B;ATP6V0A1;ITGB2L;GM-CSF;HLA-DMA;CCL20;TNFSF13
Allograft rejectionHLA-F;H2-Q10;IL12A;HLA-DPB1;TNF;CD40LG;HLA-DRB5;HLA-DOA;HLA-E
Graft-versus-host diseaseTNF;H2-AA;HLA-DOB;HLA-G;KIR3DL2;H2-Q10;HLA-E;KLRD1;HLA-DPB1
Viral myocarditisICAM1;HLA-DOB;CCND1;HLA-G;ITGB2;HLA-DRB3;ITGAL;LAMA2;HLA-DMA

CD28 has several biochemical functions, for example, SH3/SH2 adaptor activity, coreceptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD28 itself. We selected most functions CD28 had, and list some proteins which have the same functions with CD28. You can find most of the proteins on our site.

Function Related Protein
SH3/SH2 adaptor activityLAT;SKAP1;PAG1;IRS4;GRB7;SRC;SLA;GRB10;HSH2D
coreceptor activityRAMP1;ZP2;PVRL2;CD8B;CCR8;LRP5;RAMP2;LY96;PVRL1
identical protein bindingSNX33;TRAF6;S100A4;STIM1;C1QL4;BRAF;CHEK2;TPD52L1;ADIPOR2
protease bindingDPP4;STIM1;THAP5;ADAM8A;COMP;FN1;ITGB3;TP53;CD28
protein bindingSFRP5;VPS4A;RNH1;TLX3;TTLL10;RBBP7;KIR2DL4;PHF10;PRPS2

CD28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD28 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD28.

PIK3R1; GRAP2; CD80; PIK3R1; Pik3r1; GRB2; PRKCQ

Toyota, H; Sudo, K; et al. Thy28 protects against anti-CD3-mediated thymic cell death in vivo. APOPTOSIS 20:444-454(2015).
Bakdash, G; Vogelpoel, LTC; et al. Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. MUCOSAL IMMUNOLOGY 8:265-278(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can CD28 protein be used for personalized medicine? 01/13/2023

CD28 protein expression and function may be relevant for personalized treatment strategies in autoimmune diseases and cancer.

What are the potential clinical applications of targeting CD28 protein? 05/18/2021

Targeting CD28 protein may have therapeutic potential in treating autoimmune diseases, cancer immunotherapy, and organ transplantation.

How does CD28 protein impact regulatory T cells (Tregs)? 06/21/2019

CD28 signaling is important for the function and maintenance of regulatory T cells, which play a role in immune tolerance and suppression of autoimmunity.

How does CD28 protein impact cancer immunotherapy? 11/26/2018

CD28 protein is involved in enhancing the anti-tumor immune response, making it a potential target for cancer immunotherapy.

Are there any approved therapies targeting CD28 protein? 05/27/2017

Currently, there are no FDA-approved therapies specifically targeting CD28 protein, but research is ongoing in this area.

Customer Reviews (3)

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Reviews
08/24/2021

    Its unique characteristics contribute to obtaining clear and detailed structural information, enabling researchers to unravel the intricate complexities of protein interactions and conformational changes.

    08/24/2021

      Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.

      08/06/2021

        the CD28 protein's outstanding performance in ELISA and its utility in protein electron microscopy structure analysis make it a highly recommended tool for researchers.

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