Active Recombinant Human CD40 Protein, Fc-tagged
Cat.No. : | CD40-108H |
Product Overview : | Recombinant Human CD40 Protein extracellular domain 21-193aa (signal peptide removed), fused with a C-terminal Fc tag, was expressed in CHO. |
- Specification
- Gene Information
- Related Products
Description : | CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. |
Source : | CHO |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Glu 21 |
Form : | Lyophilized from sterile PBS, pH 7.4. |
Bio-activity : | Measured by its binding ability in a functional ELISA. |
Molecular Mass : | The recombinant mature human CD40 protein consists of 405 amino acids and has a calculated molecular mass of 45.2 KD. |
Endotoxin : | <1.0EU/ug, LAL method |
Purity : | >95% (SDS-PAGE) |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | CD40 CD40 molecule, TNF receptor superfamily member 5 [ Homo sapiens ] |
Official Symbol : | CD40 |
Synonyms : | CD40; CD40 molecule, TNF receptor superfamily member 5; TNFRSF5, tumor necrosis factor receptor superfamily, member 5; tumor necrosis factor receptor superfamily member 5; Bp50; p50; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; B-cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily, member 5; nerve growth factor receptor-related B-lymphocyte activation molecule; CDW40; TNFRSF5; MGC9013; |
Gene ID : | 958 |
mRNA Refseq : | NM_001250 |
Protein Refseq : | NP_001241 |
MIM : | 109535 |
UniProt ID : | P25942 |
Chromosome Location : | 20q12-q13.2 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; |
Function : | enzyme binding; protein binding; receptor activity; signal transducer activity; |
Products Types
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CD40-0810H | Recombinant Human CD40 Protein | +Inquiry |
CD40-566R | Recombinant Rhesus Macaque CD40 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD40-630M | Recombinant Mouse CD40 Protein | +Inquiry |
◆ Lysates | ||
CD40-1254CCL | Recombinant Cynomolgus CD40 cell lysate | +Inquiry |
CD40-001CCL | Recombinant Canine CD40 cell lysate | +Inquiry |
CD40-2617HCL | Recombinant Human CD40 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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