Active Recombinant Human CD40 Protein, Fc-tagged, Alexa Fluor 647 conjugated
Cat.No. : | CD40-108HAF647 |
Product Overview : | Alexa Fluor 647 conjugated recombinant human CD40 Protein extracellular domain 21-193aa (signal peptide removed), fused with a C-terminal Fc tag, was expressed in CHO. |
Availability | February 10, 2025 |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
- Download
Description : | CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. |
Source : | CHO |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized |
Bio-activity : | Measured by its binding ability in a functional ELISA. |
Molecular Mass : | 45.2 kDa |
Protein length : | 405 |
N-terminal Sequence Analysis : | Glu 21 |
Endotoxin : | < 1.0 EU/ μg by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 647 via amines Excitation = 650 nm Emission = 668 nm |
Stability : | Samples are stable for up to 12 months from date of receipt at -70 centigrade. |
Storage : | Store it under sterile conditions at -20 to-70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | CD40 CD40 molecule, TNF receptor superfamily member 5 [ Homo sapiens ] |
Official Symbol : | CD40 |
Synonyms : | CD40; CD40 molecule, TNF receptor superfamily member 5; TNFRSF5, tumor necrosis factor receptor superfamily, member 5; tumor necrosis factor receptor superfamily member 5; Bp50; p50; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; B-cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily, member 5; nerve growth factor receptor-related B-lymphocyte activation molecule; CDW40; TNFRSF5; MGC9013; |
Gene ID : | 958 |
mRNA Refseq : | NM_001250 |
Protein Refseq : | NP_001241 |
MIM : | 109535 |
UniProt ID : | P25942 |
Products Types
◆ Recombinant Protein | ||
CD40-632R | Recombinant Rhesus macaque CD40 Protein | +Inquiry |
CD40-31H | Recombinant Human CD40 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
CD40-07H | Recombinant Human CD40 Protein, hIgG/His-tagged | +Inquiry |
CD40-628H | Recombinant Human CD40 Protein | +Inquiry |
CD40-0810H | Recombinant Human CD40 Protein | +Inquiry |
◆ Lysates | ||
CD40-2617HCL | Recombinant Human CD40 cell lysate | +Inquiry |
CD40-1831MCL | Recombinant Mouse CD40 cell lysate | +Inquiry |
CD40-1262RCL | Recombinant Rat CD40 cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewIts utilization in this technique has allowed for precise visualization and determination of protein structures with remarkable clarity and resolution.
The reliable and high-quality results obtained using CD40 protein make it an excellent choice for researchers studying protein structures.
CD40 protein has proved to be an invaluable tool in protein electron microscopy structure analysis.
Q&As (5)
Ask a questionCD40 agonists have the potential to enhance immune responses against infectious agents, but their clinical use in this context is an area of ongoing research.
As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting CD40. However, clinical trials were ongoing for CD40-targeted therapies.
Yes, CD40-targeted therapies are often investigated in combination with other treatments like checkpoint inhibitors or chemotherapy to enhance their effectiveness.
Side effects may include flu-like symptoms, cytokine release syndrome, and immune-related adverse events, which can be managed with supportive care and close monitoring.
Research on CD40-targeted therapies for atherosclerosis is still in the experimental stages and not yet in advanced clinical trials.
Ask a Question for All CD40 Products
Required fields are marked with *
My Review for All CD40 Products
Required fields are marked with *
Inquiry Basket