Active Recombinant Human Chemokine (C-X-C Motif) Ligand 1, HIgG1 Fc-tagged
|Product Overview :||The extracellular domain of human CXCL1 (AAH11976.1)(Ala35-Asn107) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.|
- Gene Information
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|Description :||This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4|
|Source :||CHO cells|
|Tag :||HIgG1 Fc-tagged|
|Form :||Lyophilized from 0.2μm-filtered solution in PBS.|
|Bio-activity :||Measured by its ability to induce myeloperoxidase.|
|Molecular Mass :||34KDa (monomer)|
|AA Sequence :||Ala35-Asn107|
|Endotoxin :||<0.06 eu/μg as determined by lal>0.06>|
|Purity :||>98%, by SDS-PAGE under reducing conditions.|
|Stability :||Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.|
|Reconstitution :||Reconstitute at 100μg/ml in sterile PBS.|
|Warning :||Avoid freeze/thaw cycles.|
|Gene Name :||CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [ Homo sapiens ]|
|Official Symbol :||CXCL1|
|Synonyms :||CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); fibroblast secretory protein , FSP, GRO1, GRO1 oncogene (melanoma growth stimulating activity, alpha) , MGSA; growth-regulated alpha protein; GROa; MGSA a; NAP 3; SCYB1; MGSA alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; fibroblast secretory protein; neutrophil-activating protein 3; melanoma growth stimulatory activity alpha; GRO1 oncogene (melanoma growth-stimulating activity); GRO1 oncogene (melanoma growth stimulating activity, alpha); FSP; GRO1; MGSA; NAP-3; MGSA-a;|
|Gene ID :||2919|
|mRNA Refseq :||NM_001511|
|Protein Refseq :||NP_001502|
|UniProt ID :||P09341|
|Chromosome Location :||4q13.3|
|Pathway :||Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;|
|Function :||chemokine activity; enzyme activator activity; growth factor activity; receptor binding;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.
It mediates inflammation by promoting leukocyte migration and activation.
In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.
CXCL1 contributes to angiogenesis, supporting new blood vessel formation.
CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.
CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.
CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.
Customer Reviews (3)Write a review
Efficient delivery, great service. -
Product as described, perfect. -
Reliable for protein work. -
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