Active Recombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged, mutant
Cat.No. : | CXCL12-550H |
Product Overview : | The extracellular domain of human SDF-1γ(NP_001029058.1) (Gly21-Asn119) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | CHO cell |
Species : | Human |
Tag : | HIgG1 Fc-tagged, mutant |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to chemoattract BaF3 mouse proB cells. |
Molecular Mass : | 38KDa (monomer) |
AA Sequence : | Gly21-Asn119 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | CXCL12 chemokine (C-X-C motif) ligand 12 [ Homo sapiens ] |
Official Symbol : | CXCL12 |
Synonyms : | CXCL12; chemokine (C-X-C motif) ligand 12; SDF1, SDF1A, SDF1B, stromal cell derived factor 1; stromal cell-derived factor 1; PBSF; SCYB12; SDF 1a; SDF 1b; TLSF a; TLSF b; TPAR1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; IRH; SDF1; TLSF; SDF1A; SDF1B; |
Gene ID : | 6387 |
mRNA Refseq : | NM_000609 |
Protein Refseq : | NP_000600 |
MIM : | 600835 |
UniProt ID : | P48061 |
Chromosome Location : | 10q11.1 |
Pathway : | Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; |
Function : | CXCR chemokine receptor binding; chemokine activity; growth factor activity; receptor binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCXCL12 is being investigated for its role in neuroprotection and neuroregeneration in conditions like Alzheimer's and Parkinson's disease.
Yes, ELISA and other assays can be used to measure CXCL12 levels, aiding in the diagnosis and monitoring of certain diseases.
CXCL12 levels can serve as a biomarker for various diseases, such as HIV, cancer, and inflammatory disorders.
Scientists are exploring the potential of CXCL12-based therapies to promote vascular repair and treat heart diseases.
Researchers are studying CXCL12-based treatments to promote nerve regeneration and functional recovery after spinal cord injuries.
Customer Reviews (3)
Write a reviewThe CXCL12 protein is of exceptional quality, making it an ideal candidate to fulfill my experimental requirements.
The manufacturer's commitment to providing excellent technical support is truly commendable, as they have proven to be readily available to assist in resolving any concerns or challenges I encountered while working with the protein.
Its purity and integrity have consistently delivered reliable and robust results in my research.
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