Active Recombinant Human CXCL9 Protein (Thr21-Thr125), N-His tagged, Animal-free, Carrier-free

• Cat.No.: CXCL9-219H
• Product Overview: Recombinant Human CXCL9 Protein (Thr21-Thr125) with N-His tag was expressed in E. coli and Animal-free as well as Carrier-free.

Specification

• Description: C-X-C motif chemokine 9 (CXCL9) also named monokine induced by gamma interferon (MIG), which is a chemokine of the intercrine alpha family. CXCL9 is a 11.4kDa protein containing 103 amino acid residues. CXCL9 controls the immune cells by binding the CXCR3 which is including the cell migration and activation. During inflammation, CXCL9 is a chemotaxis for lymphocyte and macrophages. CXCL9 is participated in the process of tumor proliferation and metastasis.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized
• Bio-activity: Measure by its ability to chemoattract BaF3 cells transfected with mouse CXCR3. The ED50 for this effect is < 0.5 μg/mL.
• Molecular Mass: The protein has a calculated MW of 12.53 kDa.
  The protein migrates as 18 kDa under reducing condition (SDS-PAGE analysis).
• Protein length: Thr21-Thr125
• Endotoxin: < 0.1 EU/μg of the protein by the LAL method.
• Purity: >98% as determined by SDS-PAGE analysis.
• Storage: This product is stable after storage at:
  -20 centigrade for 12 months in lyophilized state from date of receipt.
  -20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.

Gene Information

• Gene Name: CXCL9 chemokine (C-X-C motif) ligand 9 [ Homo sapiens (human) ]
• Official Symbol: CXCL9
• Synonyms: CXCL9; chemokine (C-X-C motif) ligand 9; CMK, MIG, monokine induced by gamma interferon; C-X-C motif chemokine 9; crg 10; Humig; SCYB9; small-inducible cytokine B9; gamma-interferon-induced monokine; monokine induced by gamma interferon; monokine induced by interferon-gamma; CMK; MIG; crg-10
• Gene ID: 4283
• mRNA Refseq: NM_002416
• Protein Refseq: NP_002407
• MIM: 601704
• UniProt ID: Q07325

Reviews

02/21/2023

Customer service promptly feedback my requests, technical staff timely solve the problems that arise.

04/01/2022

The protein composition was stable and the concentration was high, which allowed me to obtain satisfactory experimental results.

Q&As

What is the relationship between CXCL9 and the chemokine receptor CXCR3?

CXCL9 can bind specifically to CXCR3 and accumulate at sites of inflammation, thereby inducing and exacerbating the inflammatory response.

Do you offer CXCL9 fused with other tags?

Yes, we will provide you with the most suitable labels according to your experimental needs.

Can CXCL9 be detected in lymphoid tissue under normal physiological conditions?

No, CXCL9 can only be detected when the organism is inflamed or infected.

CXCL9 is secreted by which cells?

CXCL9 is mainly secreted by endothelial cells and monocytes.

What diseases has CXCL9 been closely associated with the study of?

CXCL9 has been linked to pulmonary embolism, asthma and breast cancer research.