Active Recombinant Human EREG Protein

• Cat.No.: EREG-004H
• Product Overview: The mature recombinant human Ang-2 protein containing 478aa (Y19-F496) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 19-496 a.a.
• Description: This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome.
• Bio-activity: Measured by its ability to activate Tie-2 in C6 rat glial cells transfected with human Tie-2. 0.2 μg/mL of Recombinant Human Angiopoietin-2 significantly induces phosphorylation of human Tie-2.
• Molecular Mass: 56 kDa
• Product-Related Proteins: 19-496
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: ANGPT2 angiopoietin 2 [ Homo sapiens (human) ]
• Official Symbol: EREG
• Synonyms: ANGPT2; angiopoietin 2; ANG2; AGPT2; LMPHM10; angiopoietin-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a
• Gene ID: 285
• mRNA Refseq: NM_001147
• Protein Refseq: NP_001138
• MIM: 601922
• UniProt ID: O15123